Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells.
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Protein tyrosine phosphatase Shp2 (Ptpn11) plays an important role in maintenance of chromosome stabilityInhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations.SHP2E76K mutant promotes lung tumorigenesis in transgenic miceChromosome instability underlies hematopoietic stem cell dysfunction and lymphoid neoplasia associated with impaired Fbw7-mediated cyclin E regulationIdentification of cryptotanshinone as an inhibitor of oncogenic protein tyrosine phosphatase SHP2 (PTPN11).Activating mutations in protein tyrosine phosphatase Ptpn11 (Shp2) enhance reactive oxygen species production that contributes to myeloproliferative disorderLeukemogenic Ptpn11 allele causes defective erythropoiesis in mice.Mutated Ptpn11 alters leukemic stem cell frequency and reduces the sensitivity of acute myeloid leukemia cells to Mcl1 inhibition.Shp2 function in hematopoietic stem cell biology and leukemogenesis.Gain-of-function mutations of Ptpn11 (Shp2) cause aberrant mitosis and increase susceptibility to DNA damage-induced malignanciesMetabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiationInduction of a tumor-associated activating mutation in protein tyrosine phosphatase Ptpn11 (Shp2) enhances mitochondrial metabolism, leading to oxidative stress and senescence.Targeting protein tyrosine phosphatase SHP2 for the treatment of PTPN11-associated malignanciesNew and Unexpected Biological Functions for the Src-Homology 2 Domain-Containing Phosphatase SHP-2 in the Gastrointestinal Tract.Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment.SHP-2 phosphatase contributes to KRAS-driven intestinal oncogenesis but prevents colitis-associated cancer development.Impact of age on the survival of pediatric leukemia: an analysis of 15083 children in the SEER database.Dual faces of SH2-containing protein-tyrosine phosphatase Shp2/PTPN11 in tumorigenesis.Engineering subtle targeted mutations into the mouse genome.Ras/Raf/MEK/ERK Pathway Activation in Childhood Acute Lymphoblastic Leukemia and Its Therapeutic TargetingMechanisms and clinical applications of chromosomal instability in lymphoid malignancy.SHP2 overexpression enhances the invasion and metastasis of ovarian cancer in vitro and in vivo.Turning the tide in myelodysplastic/myeloproliferative neoplasms.Role of SHP2 in hematopoiesis and leukemogenesis.Patient-derived xenotransplants can recapitulate the genetic driver landscape of acute leukemias.Genetic mutational profiling analysis of T cell acute lymphoblastic leukemia reveal mutant FBXW7 as a prognostic indicator for inferior survival.Cancer: Bad neighbours cause bad blood.Aberrant Signaling Pathways in T-Cell Acute Lymphoblastic Leukemia.DPP4 truncated GM-CSF and IL-3 manifest distinct receptor-binding and regulatory functions compared with their full-length forms.Shp2 regulates leukemic stem cell frequency in MLL-rearranged acute myeloid leukemia.Natural variant of the Helicobacter pylori CagA oncoprotein that lost the ability to interact with PAR1.Mice expressing KrasG12D in hematopoietic multipotent progenitor cells develop neonatal myeloid leukemia.Pharmacologic inhibition of PI3K p110δ in mutant Shp2E76K-expressing mice.Yolk sac erythromyeloid progenitors expressing gain of function PTPN11 have functional features of JMML but are not sufficient to cause disease in mice.Gain-of-function mutation in PTPN11 in histiocytic sarcomas of Bernese Mountain Dogs.Regulatory Mechanisms and Novel Therapeutic Targeting Strategies for Protein Tyrosine Phosphatases.Azacitidine and Sorafenib Therapy in a Pediatric Patient With Refractory Acute Myeloid Leukemia With Monosomy 7 and Somatic PTPN11 Mutation.CCL3 is a key mediator for the leukemogenic effect of Ptpn11-activating mutations in the stem-cell microenvironment.Gain-of-function mutations in the gene encoding the tyrosine phosphatase SHP2 induce hydrocephalus in a catalytically dependent manner.Clinical course of juvenile myelomonocytic leukemia in the blast crisis phase treated by acute myeloid leukemia-oriented chemotherapy and allogeneic hematopoietic stem cell transplantation.
P2860
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P2860
Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells.
description
2011 nî lūn-bûn
@nan
2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Non-lineage/stage-restricted e ...... mation of hematopoietic cells.
@ast
Non-lineage/stage-restricted e ...... mation of hematopoietic cells.
@en
type
label
Non-lineage/stage-restricted e ...... mation of hematopoietic cells.
@ast
Non-lineage/stage-restricted e ...... mation of hematopoietic cells.
@en
prefLabel
Non-lineage/stage-restricted e ...... mation of hematopoietic cells.
@ast
Non-lineage/stage-restricted e ...... mation of hematopoietic cells.
@en
P2093
P2860
P356
P1476
Non-lineage/stage-restricted e ...... mation of hematopoietic cells.
@en
P2093
Caiying Guo
Cheng-Kui Qu
Howard J Meyerson
Stanton L Gerson
Wen-Mei Yu
P2860
P304
P356
10.1084/JEM.20110450
P407
P577
2011-09-19T00:00:00Z