Domain-domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channel
about
The KCNQ1 channel - remarkable flexibility in gating allows for functional versatilityKCNQ1 channel modulation by KCNE proteins via the voltage-sensing domainbSUM: A bead-supported unilamellar membrane system facilitating unidirectional insertion of membrane proteins into giant vesicles.KCNE3 acts by promoting voltage sensor activation in KCNQ1.Gating mechanisms underlying deactivation slowing by two KCNQ1 atrial fibrillation mutations.cAMP-dependent regulation of IKs single-channel kinetics.Voltage-Dependent Gating: Novel Insights from KCNQ1 Channels.Photo-Cross-Linking of IKs Demonstrates State-Dependent Interactions between KCNE1 and KCNQ1.Fatty acid analogue N-arachidonoyl taurine restores function of IKs channels with diverse long QT mutations.Molecular Basis of Cardiac Delayed Rectifier Potassium Channel Function and Pharmacology.Domain-to-domain coupling in voltage-sensing phosphatase.Unnatural amino acid photo-crosslinking of the IKs channel complex demonstrates a KCNE1:KCNQ1 stoichiometry of up to 4:4.hERG S4-S5 linker acts as a voltage-dependent ligand that binds to the activation gate and locks it in a closed statePotassium channels in the heart: structure, function and regulation.Inactivation of KCNQ1 potassium channels reveals dynamic coupling between voltage sensing and pore opening.KCNE1 and KCNE3 modulate KCNQ1 channels by affecting different gating transitions.Studying Kv Channels Function using Computational Methods.Genetic Code Expansion and Optoproteomics.Mechanisms Underlying the Dual Effect of Polyunsaturated Fatty Acid Analogs on Kv7.1
P2860
Q27013934-AE8161A3-B001-4C07-8C68-5290E12F982BQ27027928-0B0ABCF2-46FD-4E24-A5DB-58377B70A02AQ36407990-7C83A058-B25E-48B3-9E35-073915563EBBQ36435428-AD9454B7-D868-47DB-A9CF-55808933DC57Q37739849-DD30173B-8FDA-469E-BB91-7DC392736D64Q38688887-D8FD166B-98A1-4C2C-9883-53AC30195D5CQ38690407-E67C836B-6FF6-46E9-A165-85C520E48275Q38696328-571D2BDA-70A9-448E-85A8-067DD4B2A42FQ38805694-51CDDD47-9B41-460E-BC89-ED9020F0E9B0Q38854244-09F270B8-3E97-4FF7-8374-104902A3F064Q39458536-45E4F141-AABF-4EBB-A752-CC4D105D9009Q39477676-2B209285-7BAF-4C56-B3FF-4B09340A6659Q42274294-1F24F52E-2547-49C8-830F-04A86AA38FBAQ44505007-F76A2A48-84E6-46B2-8C4C-1A5093517E82Q47127280-7FBA6443-FB46-4602-9FE1-B6DE72DBB6E5Q47928241-23C4C9D7-A665-4BE6-8CA5-00E85CAE1FE6Q50067406-61E357CC-AA9E-43F1-A74D-8441D19352DEQ52429674-2B9B50AB-9B23-4F42-ACE0-75B16423FFDEQ58749124-F391183B-112F-4177-8AE4-1D9FF67724E0
P2860
Domain-domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channel
description
2014 nî lūn-bûn
@nan
2014 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Domain-domain interactions det ...... ulation of the IKs ion channel
@ast
Domain-domain interactions det ...... ulation of the IKs ion channel
@en
type
label
Domain-domain interactions det ...... ulation of the IKs ion channel
@ast
Domain-domain interactions det ...... ulation of the IKs ion channel
@en
prefLabel
Domain-domain interactions det ...... ulation of the IKs ion channel
@ast
Domain-domain interactions det ...... ulation of the IKs ion channel
@en
P2093
P2860
P356
P1433
P1476
Domain-domain interactions det ...... ulation of the IKs ion channel
@en
P2093
Guohui Zhang
Holly E Kinser
Hongwu Liang
Jianmin Cui
Jingyi Shi
Kelli McFarland
Marina A Kasimova
Mark A Zaydman
Mounir Tarek
Zachary Beller
P2860
P304
P356
10.7554/ELIFE.03606
P407
P50
P577
2014-12-23T00:00:00Z