Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase - Wikidata - wikimedia - TriplyDB

Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase

Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase

http://www.wikidata.org/entity/Q35275756

about

Ubiquitin proteasome system research in gastrointestinal cancer E3 Ubiquitin Ligases Neurobiological Mechanisms: Development to Degeneration Taming of the beast: shaping Myc-dependent amplification Tipping the MYC-MIZ1 balance: targeting the HUWE1 ubiquitin ligase selectively blocks MYC-activated genes.Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cells.Strategies to Inhibit Myc and Their Clinical Applicability The E3 ligase Mule protects the heart against oxidative stress and mitochondrial dysfunction through Myc-dependent inactivation of Pgc-1α and Pink1.E3 ubiquitin ligase Mule targets β-catenin under conditions of hyperactive Wnt signaling.MYC in pancreatic cancer: novel mechanistic insights and their translation into therapeutic strategies.Deubiquitinating c-Myc: USP36 steps up in the nucleolus.HUWE1 interacts with PCNA to alleviate replication stress.Myc Induces miRNA-Mediated Apoptosis in Response to HDAC Inhibition in Hematologic Malignancies.Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer.Paving the way to targeting HECT ubiquitin ligases.A conserved quality-control pathway that mediates degradation of unassembled ribosomal proteins.Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation.Distribution of the c-MYC gene product in colorectal neoplasia.A conformational switch regulates the ubiquitin ligase HUWE1.Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling.Ubiquitin ligases in oncogenic transformation and cancer therapy.LncRNA IDH1-AS1 links the functions of c-Myc and HIF1α via IDH1 to regulate the Warburg effect.Structural Insights into c-Myc-interacting Zinc Finger Protein-1 (Miz-1) Delineate Domains Required for DNA Scanning and Sequence-specific Binding.UbFluor: A Fluorescent Thioester to Monitor HECT E3 Ligase Catalysis.Miz-1 and Max compete to engage c-Myc: implication for the mechanism of inhibition of c-Myc transcriptional activity by Miz-1.Ubiquitination by HUWE1 in tumorigenesis and beyond HUWE1 Ubiquitin Ligase Regulates Endoreplication and Antagonizes JNK Signaling During Salivary Gland Development

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Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase

http://www.wikidata.org/entity/Q35275756

description

2014 nî lūn-bûn

@nan

2014 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2014年の論文

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2014年論文

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2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

Tumor cell-specific inhibition ...... of the HUWE1 ubiquitin ligase

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Tumor cell-specific inhibition ...... of the HUWE1 ubiquitin ligase

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type

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Tumor cell-specific inhibition ...... of the HUWE1 ubiquitin ligase

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Tumor cell-specific inhibition ...... of the HUWE1 ubiquitin ligase

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Tumor cell-specific inhibition ...... of the HUWE1 ubiquitin ligase

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Tumor cell-specific inhibition ...... of the HUWE1 ubiquitin ligase

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EMBO Molecular Medicine

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Tumor cell-specific inhibition ...... of the HUWE1 ubiquitin ligase

@en

P2093

Armin Wiegering

http://www.w3.org/2001/XMLSchema#string

Carsten P Ade

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Christoph Otto

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Guido Boehmelt

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Jennyfer Bultinck

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Judith Müller

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Kevin Myant

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Laura A Jaenicke

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Matthias Treu

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Michael Gmachl

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P2860

Global cancer statistics

Small molecule inhibitors of aurora-a induce proteasomal degradation of N-myc in childhood neuroblastoma

ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor

Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity

The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells

Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1

An alternative pathway for gene regulation by Myc

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Comprehensive molecular characterization of human colon and rectal cancer

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1525-1541

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scholarly article

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10.15252/EMMM.201403927

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12

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6

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2014-12-01T00:00:00Z

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25253726

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