Apoptotic effects of platelet factor VIII on megakaryopoiesis: implications for a modified human FVIII for platelet-based gene therapy. - Wikidata - wikimedia - TriplyDB

Apoptotic effects of platelet factor VIII on megakaryopoiesis: implications for a modified human FVIII for platelet-based gene therapy.

Apoptotic effects of platelet factor VIII on megakaryopoiesis: implications for a modified human FVIII for platelet-based gene therapy.

http://www.wikidata.org/entity/Q35306206

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Megakaryocyte- and megakaryocyte precursor-related gene therapies α-Defensins Induce a Post-translational Modification of Low Density Lipoprotein (LDL) That Promotes Atherosclerosis at Normal Levels of Plasma Cholesterol Overexpression of factor VIII after AAV delivery is transiently associated with cellular stress in hemophilia A mice.Novel factor VIII variants with a modified furin cleavage site improve the efficacy of gene therapy for hemophilia A.Obstacles and future of gene therapy for hemophilia.Platelet-delivered therapeutics.Targeting factor VIII expression to platelets for hemophilia A gene therapy does not induce an apparent thrombotic risk in mice.Platelet-Targeted Gene Therapy for Hemophilia.

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Apoptotic effects of platelet factor VIII on megakaryopoiesis: implications for a modified human FVIII for platelet-based gene therapy.

http://www.wikidata.org/entity/Q35306206

description

2014 nî lūn-bûn

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2014 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2014 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2014年の論文

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Journal of Thrombosis and Haemostasis

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D E Sabatino

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P2860

In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector

Analysis of the spatial and temporal characteristics of platelet-delivered factor VIII-based clots

Thrombus formation: direct real-time observation and digital analysis of thrombus assembly in a living mouse by confocal and widefield intravital microscopy.

Bleeding complications after hematopoietic stem cell transplantation.

Platelet-delivered factor VIII provides limited resistance to anti-factor VIII inhibitors.

Rational design of a fully active, long-acting PEGylated factor VIII for hemophilia A treatment.

In vivo efficacy of platelet-delivered, high specific activity factor VIII variants

Advances toward gene therapy for hemophilia at the millennium.

In vivo enrichment of genetically manipulated platelets corrects the murine hemophilic phenotype and induces immune tolerance even using a low multiplicity of infection

Recombinant canine B-domain-deleted FVIII exhibits high specific activity and is safe in the canine hemophilia A model.

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2102-2112

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10.1111/JTH.12749

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12

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