Analysis of the spatial and temporal characteristics of platelet-delivered factor VIII-based clots
about
Megakaryocyte- and megakaryocyte precursor-related gene therapiesThe effect of factor VIII deficiencies and replacement and bypass therapies on thrombus formation under venous flow conditions in microfluidic and computational modelsA chimeric platelet-targeted urokinase prodrug selectively blocks new thrombus formationHemophilia A gene therapy via intraosseous delivery of factor VIII-lentiviral vectorsLessons Learned from Animal Models of Inherited Bleeding Disorders.Structural and therapeutic insights from the species specificity and in vivo antithrombotic activity of a novel alphaIIb-specific alphaIIbbeta3 antagonist.Infusion of mature megakaryocytes into mice yields functional platelets.Monocyte-bound PF4 in the pathogenesis of heparin-induced thrombocytopenia.The kinetics of αIIbβ3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy.Targeting recombinant thrombomodulin fusion protein to red blood cells provides multifaceted thromboprophylaxis.Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo.Endothelial antigen assembly leads to thrombotic complications in heparin-induced thrombocytopeniaNew insights into the spatiotemporal localization of prothrombinase in vivo.ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 2. Pathogenicity in an animal model.In vivo efficacy of platelet-delivered, high specific activity factor VIII variantsDirected engineering of a high-expression chimeric transgene as a strategy for gene therapy of hemophilia A.Longistatin, a plasminogen activator, is key to the availability of blood-meals for ixodid ticksRelative contributions of stromal interaction molecule 1 and CalDAG-GEFI to calcium-dependent platelet activation and thrombosis.A zymogen-like factor Xa variant corrects the coagulation defect in hemophiliaPlatelets as delivery systems for disease treatmentsProtein replacement therapy and gene transfer in canine models of hemophilia A, hemophilia B, von willebrand disease, and factor VII deficiency.Apoptotic effects of platelet factor VIII on megakaryopoiesis: implications for a modified human FVIII for platelet-based gene therapy.Procoagulant activity induced by vascular injury determines contribution of elevated factor VIII to thrombosis and thrombus stability in mice.Intraosseous delivery of lentiviral vectors targeting factor VIII expression in platelets corrects murine hemophilia A.Ectopic platelet-delivered factor (F) VIII for the treatment of Hemophilia A: Plasma and platelet FVIII, is it all the same?Enhanced lysis and accelerated establishment of viscoelastic properties of fibrin clots are associated with pulmonary embolism.Gene therapy for haemophilia: a long and winding road.New approaches to gene and cell therapy for hemophilia.Platelet-delivered therapeutics.Rate-limiting roles of the tenase complex of factors VIII and IX in platelet procoagulant activity and formation of platelet-fibrin thrombi under flow.Extrahepatic sources of factor VIII potentially contribute to the coagulation cascade correcting the bleeding phenotype of mice with hemophilia A.Targeting factor VIII expression to platelets for hemophilia A gene therapy does not induce an apparent thrombotic risk in mice.A quantitative and humane tail bleeding assay for efficacy evaluation of antihaemophilic factors in haemophilia A mice.A sensitive venous bleeding model in haemophilia A mice: effects of two recombinant FVIII products (N8 and Advate(®)).Abnormal von Willebrand factor secretion, factor VIII stabilization and thrombus dynamics in type 2N von Willebrand disease mice.Dysregulated coagulation associated with hypofibrinogenaemia and plasma hypercoagulability: implications for identifying coagulopathic mechanisms in humans.A rapid pro-hemostatic approach to overcome direct oral anticoagulants.Platelet-Targeted Gene Therapy for Hemophilia.Neutrophil accumulation and NET release contribute to thrombosis in HIT
P2860
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P2860
Analysis of the spatial and temporal characteristics of platelet-delivered factor VIII-based clots
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Analysis of the spatial and te ...... ivered factor VIII-based clots
@ast
Analysis of the spatial and te ...... ivered factor VIII-based clots
@en
type
label
Analysis of the spatial and te ...... ivered factor VIII-based clots
@ast
Analysis of the spatial and te ...... ivered factor VIII-based clots
@en
prefLabel
Analysis of the spatial and te ...... ivered factor VIII-based clots
@ast
Analysis of the spatial and te ...... ivered factor VIII-based clots
@en
P2093
P2860
P1433
P1476
Analysis of the spatial and te ...... ivered factor VIII-based clots
@en
P2093
Jamie Gewirtz
Michael Neyman
Mortimer Poncz
P2860
P304
P356
10.1182/BLOOD-2008-04-152959
P407
P577
2008-06-16T00:00:00Z