Balancing act: deubiquitinating enzymes in the nervous system.
about
Ubiquitin-specific protease 25 functions in Endoplasmic Reticulum-associated degradationProteomics in Traditional Chinese Medicine with an Emphasis on Alzheimer's DiseaseMisframed ubiquitin and impaired protein quality control: an early event in Alzheimer's diseaseThe role of deubiquitinating enzymes in synaptic function and nervous system diseasesThe role of targeted protein degradation in early neural developmentDysregulation of Ubiquitin-Proteasome System in Neurodegenerative DiseasesSynaptic strength is bidirectionally controlled by opposing activity-dependent regulation of Nedd4-1 and USP8Loss of Usp9x disrupts cortical architecture, hippocampal development and TGFβ-mediated axonogenesisIn vivo transduction of neurons with TAT-UCH-L1 protects brain against controlled cortical impact injury.An optimal ubiquitin-proteasome pathway in the nervous system: the role of deubiquitinating enzymes.Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growthSystematic analysis of the physiological importance of deubiquitinating enzymes.Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine clusterToward understanding Machado-Joseph diseaseCytoplasmic Ubiquitin-Specific Protease 19 (USP19) Modulates Aggregation of Polyglutamine-Expanded Ataxin-3 and Huntingtin through the HSP90 Chaperone.LRRK2 and ubiquitination: implications for kinase inhibitor therapyThe Machado-Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53The deubiquitylase USP37 links REST to the control of p27 stability and cell proliferationIdentification of genes underlying hypoxia tolerance in Drosophila by a P-element screen.The deubiquitinase ataxin-3 requires Rad23 and DnaJ-1 for its neuroprotective role in Drosophila melanogaster.Deubiquitinases as a signaling target of oxidative stress.USP5 Is Dispensable for Monoubiquitin Maintenance in DrosophilaJosD1, a membrane-targeted deubiquitinating enzyme, is activated by ubiquitination and regulates membrane dynamics, cell motility, and endocytosisDynamics of an Active-Site Flap Contributes to Catalysis in a JAMM Family Metallo Deubiquitinase.Toward RNAi therapy for the polyglutamine disease Machado-Joseph diseaseUbiquitination regulates the neuroprotective function of the deubiquitinase ataxin-3 in vivo.The WD40-repeat protein-containing deubiquitinase complex: catalysis, regulation, and potential for therapeutic intervention.The WD40-repeat proteins WDR-20 and WDR-48 bind and activate the deubiquitinating enzyme USP-46 to promote the abundance of the glutamate receptor GLR-1 in the ventral nerve cord of Caenorhabditis elegans.Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.The de-ubiquitinating enzyme ataxin-3 does not modulate disease progression in a knock-in mouse model of Huntington disease.Could dysregulation of UPS be a common underlying mechanism for cancer and neurodegeneration? Lessons from UCHL1.Cathepsin B: multiple roles in cancer.Protein aggregate formation in oligodendrocytes: tau and the cytoskeleton at the intersection of neuroprotection and neurodegeneration.Chemical and semisynthetic approaches to study and target deubiquitinases.Hes1: the maestro in neurogenesis.Inhibition of UCH-L1 in oligodendroglial cells results in microtubule stabilization and prevents α-synuclein aggregate formation by activating the autophagic pathway: implications for multiple system atrophy.Life and death in the trash heap: The ubiquitin proteasome pathway and UCHL1 in brain aging, neurodegenerative disease and cerebral Ischemia.Inhibition of protein deubiquitination by PR-619 activates the autophagic pathway in OLN-t40 oligodendroglial cells.Bacterial effector NleL promotes enterohemorrhagic E. coli-induced attaching and effacing lesions by ubiquitylating and inactivating JNK.Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease
P2860
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P2860
Balancing act: deubiquitinating enzymes in the nervous system.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Balancing act: deubiquitinating enzymes in the nervous system.
@ast
Balancing act: deubiquitinating enzymes in the nervous system.
@en
type
label
Balancing act: deubiquitinating enzymes in the nervous system.
@ast
Balancing act: deubiquitinating enzymes in the nervous system.
@en
prefLabel
Balancing act: deubiquitinating enzymes in the nervous system.
@ast
Balancing act: deubiquitinating enzymes in the nervous system.
@en
P2860
P1476
Balancing act: deubiquitinating enzymes in the nervous system.
@en
P2093
Henry L Paulson
P2860
P304
P356
10.1016/J.TINS.2011.05.004
P50
P577
2011-06-24T00:00:00Z