IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease - Wikidata - wikimedia - TriplyDB

IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease

IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease

http://www.wikidata.org/entity/Q35370058

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Asparaginase treatment side-effects may be due to genes with homopolymeric Asn codons (Review-Hypothesis)The many faces of autophagy dysfunction in Huntington's disease: from mechanism to therapy Mouse models of polyglutamine diseases: review and data table. Part I Axis of ageing: telomeres, p53 and mitochondria Mouse models of polyglutamine diseases in therapeutic approaches: review and data table. Part II.Huntington's disease: underlying molecular mechanisms and emerging concepts Shaping the role of mitochondria in the pathogenesis of Huntington's disease The autophagy-related gene 14 (Atg14) is regulated by forkhead box O transcription factors and circadian rhythms and plays a critical role in hepatic autophagy and lipid metabolism Tamoxifen reduces fat mass by boosting reactive oxygen species Insulin resistance in brain alters dopamine turnover and causes behavioral disorders.Expression Profiling of mRNAs and Long Non-Coding RNAs in Aged Mouse Olfactory Bulb.microRNA-128a dysregulation in transgenic Huntington's disease monkeys.Insulin action in brain regulates systemic metabolism and brain function.Ferroptosis: Death by Lipid Peroxidation.A symptomatic Fabry disease mouse model generated by inducing globotriaosylceramide synthesis.MicroRNA-126 suppresses mesothelioma malignancy by targeting IRS1 and interfering with the mitochondrial function Differential effects of delayed aging on phenotype and striatal pathology in a murine model of Huntington disease.Inhibition of adenylyl cyclase type 5 increases longevity and healthful aging through oxidative stress protection Protective Effect of Sevoflurane Postconditioning against Cardiac Ischemia/Reperfusion Injury via Ameliorating Mitochondrial Impairment, Oxidative Stress and Rescuing Autophagic Clearance.Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy.IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action.Assessing Basal and Acute Autophagic Responses in the Adult Drosophila Nervous System: The Impact of Gender, Genetics and Diet on Endogenous Pathway Profiles Mini-review: Retarding aging in murine genetic models of neurodegeneration Mitochondrial deficiency: a double-edged sword for aging and neurodegeneration.Neuroinflammatory and autonomic mechanisms in diabetes and hypertension.Neuronal overexpression of insulin receptor substrate 2 leads to increased fat mass, insulin resistance, and glucose intolerance during aging.Network analysis of human post-mortem microarrays reveals novel genes, microRNAs, and mechanistic scenarios of potential importance in fighting huntington's disease.Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis.Targeting tissue-specific metabolic signaling pathways in aging: the promise and limitations.Insulin-Like Growth Factor 1: At the Crossroads of Brain Development and Aging.Integrating metabolism and longevity through insulin and IGF1 signaling.Insulin-like growth factors and insulin: at the crossroad between tumor development and longevity.Neuroinflammation and neurodegeneration in overnutrition-induced diseases.Mechanisms of action of brain insulin against neurodegenerative diseases.Mitochondrial alteration in type 2 diabetes and obesity: an epigenetic link.IRS2 integrates insulin/IGF1 signalling with metabolism, neurodegeneration and longevity.Activation of IGF-1 and insulin signaling pathways ameliorate mitochondrial function and energy metabolism in Huntington's Disease human lymphoblasts.Interaction between nonviral reprogrammed fibroblast stem cells and trophic factors for brain repair.Delaying aging is neuroprotective in Parkinson's disease: a genetic analysis in C. elegans models.Mitochondrial quality-control dysregulation in conditional HO-1-/- mice.

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P2860

IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease

http://www.wikidata.org/entity/Q35370058

description

2011 nî lūn-bûn

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2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

IRS2 increases mitochondrial d ...... se model of Huntington disease

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IRS2 increases mitochondrial d ...... se model of Huntington disease

@en

type

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IRS2 increases mitochondrial d ...... se model of Huntington disease

@ast

IRS2 increases mitochondrial d ...... se model of Huntington disease

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IRS2 increases mitochondrial d ...... se model of Huntington disease

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IRS2 increases mitochondrial d ...... se model of Huntington disease

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P1433

Journal of Clinical Investigation

P1476

IRS2 increases mitochondrial d ...... se model of Huntington disease

@en

P2093

Aldo Rozzo

http://www.w3.org/2001/XMLSchema#string

Dimitri Krainc

http://www.w3.org/2001/XMLSchema#string

Gregory R Kelley

http://www.w3.org/2001/XMLSchema#string

Isabella Palazzolo

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Xiaocheng Dong

http://www.w3.org/2001/XMLSchema#string

Zhiyong Cheng

http://www.w3.org/2001/XMLSchema#string

P2860

Disruption of IRS-2 causes type 2 diabetes in mice

Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes

Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

Resveratrol improves health and survival of mice on a high-calorie diet

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice

Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake

Mice transgenic for an expanded CAG repeat in the Huntington's disease gene develop diabetes

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4070-4081

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scholarly article

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10.1172/JCI46305

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10

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P478

121

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Marianna Sadagurski

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2011-09-19T00:00:00Z

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21926467

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Huntington disease

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3195462

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