IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease
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Asparaginase treatment side-effects may be due to genes with homopolymeric Asn codons (Review-Hypothesis)The many faces of autophagy dysfunction in Huntington's disease: from mechanism to therapyMouse models of polyglutamine diseases: review and data table. Part IAxis of ageing: telomeres, p53 and mitochondriaMouse models of polyglutamine diseases in therapeutic approaches: review and data table. Part II.Huntington's disease: underlying molecular mechanisms and emerging conceptsShaping the role of mitochondria in the pathogenesis of Huntington's diseaseThe autophagy-related gene 14 (Atg14) is regulated by forkhead box O transcription factors and circadian rhythms and plays a critical role in hepatic autophagy and lipid metabolismTamoxifen reduces fat mass by boosting reactive oxygen speciesInsulin resistance in brain alters dopamine turnover and causes behavioral disorders.Expression Profiling of mRNAs and Long Non-Coding RNAs in Aged Mouse Olfactory Bulb.microRNA-128a dysregulation in transgenic Huntington's disease monkeys.Insulin action in brain regulates systemic metabolism and brain function.Ferroptosis: Death by Lipid Peroxidation.A symptomatic Fabry disease mouse model generated by inducing globotriaosylceramide synthesis.MicroRNA-126 suppresses mesothelioma malignancy by targeting IRS1 and interfering with the mitochondrial functionDifferential effects of delayed aging on phenotype and striatal pathology in a murine model of Huntington disease.Inhibition of adenylyl cyclase type 5 increases longevity and healthful aging through oxidative stress protectionProtective Effect of Sevoflurane Postconditioning against Cardiac Ischemia/Reperfusion Injury via Ameliorating Mitochondrial Impairment, Oxidative Stress and Rescuing Autophagic Clearance.Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy.IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action.Assessing Basal and Acute Autophagic Responses in the Adult Drosophila Nervous System: The Impact of Gender, Genetics and Diet on Endogenous Pathway ProfilesMini-review: Retarding aging in murine genetic models of neurodegenerationMitochondrial deficiency: a double-edged sword for aging and neurodegeneration.Neuroinflammatory and autonomic mechanisms in diabetes and hypertension.Neuronal overexpression of insulin receptor substrate 2 leads to increased fat mass, insulin resistance, and glucose intolerance during aging.Network analysis of human post-mortem microarrays reveals novel genes, microRNAs, and mechanistic scenarios of potential importance in fighting huntington's disease.Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis.Targeting tissue-specific metabolic signaling pathways in aging: the promise and limitations.Insulin-Like Growth Factor 1: At the Crossroads of Brain Development and Aging.Integrating metabolism and longevity through insulin and IGF1 signaling.Insulin-like growth factors and insulin: at the crossroad between tumor development and longevity.Neuroinflammation and neurodegeneration in overnutrition-induced diseases.Mechanisms of action of brain insulin against neurodegenerative diseases.Mitochondrial alteration in type 2 diabetes and obesity: an epigenetic link.IRS2 integrates insulin/IGF1 signalling with metabolism, neurodegeneration and longevity.Activation of IGF-1 and insulin signaling pathways ameliorate mitochondrial function and energy metabolism in Huntington's Disease human lymphoblasts.Interaction between nonviral reprogrammed fibroblast stem cells and trophic factors for brain repair.Delaying aging is neuroprotective in Parkinson's disease: a genetic analysis in C. elegans models.Mitochondrial quality-control dysregulation in conditional HO-1-/- mice.
P2860
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P2860
IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease
description
2011 nî lūn-bûn
@nan
2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
IRS2 increases mitochondrial d ...... se model of Huntington disease
@ast
IRS2 increases mitochondrial d ...... se model of Huntington disease
@en
type
label
IRS2 increases mitochondrial d ...... se model of Huntington disease
@ast
IRS2 increases mitochondrial d ...... se model of Huntington disease
@en
prefLabel
IRS2 increases mitochondrial d ...... se model of Huntington disease
@ast
IRS2 increases mitochondrial d ...... se model of Huntington disease
@en
P2093
P2860
P356
P1476
IRS2 increases mitochondrial d ...... se model of Huntington disease
@en
P2093
Aldo Rozzo
Dimitri Krainc
Gregory R Kelley
Isabella Palazzolo
Xiaocheng Dong
Zhiyong Cheng
P2860
P304
P356
10.1172/JCI46305
P407
P577
2011-09-19T00:00:00Z