Targeted inhibition of calpain reduces myocardial hypertrophy and fibrosis in mouse models of type 1 diabetes - Wikidata - wikimedia - TriplyDB

Targeted inhibition of calpain reduces myocardial hypertrophy and fibrosis in mouse models of type 1 diabetes

Targeted inhibition of calpain reduces myocardial hypertrophy and fibrosis in mouse models of type 1 diabetes

http://www.wikidata.org/entity/Q35404816

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Electrophysiological Mechanisms of Bayés Syndrome: Insights from Clinical and Mouse Studies Molecular and Cellular Mechanisms of Cardiovascular Disorders in Diabetes Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy Calpain 2 activation of P-TEFb drives megakaryocyte morphogenesis and is disrupted by leukemogenic GATA1 mutation Urinary podocyte microparticles identify prealbuminuric diabetic glomerular injury.Inhibition of calpain reduces oxidative stress and attenuates endothelial dysfunction in diabetes.Metabolic and Biochemical Stressors in Diabetic Cardiomyopathy.Protective effects of Acyl-coA thioesterase 1 on diabetic heart via PPARα/PGC1α signaling.Prognostic significance of Capn4 overexpression in intrahepatic cholangiocarcinoma Myocardial remodeling in diabetic cardiomyopathy associated with cardiac mast cell activation.Aldosterone signaling through transient receptor potential melastatin 7 cation channel (TRPM7) and its α-kinase domain Calpain-dependent cleavage of junctophilin-2 and T-tubule remodeling in a mouse model of reversible heart failure Over-expression of calpastatin inhibits calpain activation and attenuates post-infarction myocardial remodeling.Updating experimental models of diabetic cardiomyopathy Calpain-1 induces endoplasmic reticulum stress in promoting cardiomyocyte apoptosis following hypoxia/reoxygenation.Chronic Inhibition of PDE5 Limits Pro-Inflammatory Monocyte-Macrophage Polarization in Streptozotocin-Induced Diabetic Mice Silencing of miR-195 reduces diabetic cardiomyopathy in C57BL/6 mice Molecular Determinants of Calpain-dependent Cleavage of Junctophilin-2 Protein in Cardiomyocytes.Histone deacetylase (HDAC) inhibition improves myocardial function and prevents cardiac remodeling in diabetic mice.Deletion of capn4 Protects the Heart Against Endotoxemic Injury by Preventing ATP Synthase Disruption and Inhibiting Mitochondrial Superoxide Generation Cardiac protective effects of dexrazoxane on animal cardiotoxicity model induced by anthracycline combined with trastuzumab is associated with upregulation of calpain-2.Deficiency of Capn4 gene inhibits nuclear factor-κB (NF-κB) protein signaling/inflammation and reduces remodeling after myocardial infarction.Regulation and physiological roles of the calpain system in muscular disorders Altered sympathetic nervous system signaling in the diabetic heart: emerging targets for molecular imaging.Calpain-1 regulation of matrix metalloproteinase 2 activity in vascular smooth muscle cells facilitates age-associated aortic wall calcification and fibrosis.Role of Calpain in Pathogenesis of Human Disease Processes.Disruption of calpain reduces lipotoxicity-induced cardiac injury by preventing endoplasmic reticulum stress.Heat stress prevents lipopolysaccharide-induced apoptosis in pulmonary microvascular endothelial cells by blocking calpain/p38 MAPK signalling Critical role of calpain in inflammation The role of calpains in myocardial remodelling and heart failure.Delayed, oral pharmacological inhibition of calpains attenuates adverse post-infarction remodelling.Relevance of mouse models of cardiac fibrosis and hypertrophy in cardiac research.Calpain research for drug discovery: challenges and potential.Sex, sex steroids, and diabetic cardiomyopathy: making the case for experimental focus.L-type calcium channel blocker ameliorates diabetic encephalopathy by modulating dysregulated calcium homeostasis.Calpain-activated mTORC2/Akt pathway mediates airway smooth muscle remodelling in asthma.Cryptotanshinone Inhibits STAT3 Signaling to Alleviate Cardiac Fibrosis in Type 1-like Diabetic Rats.The Calcium-Induced Regulation in the Molecular and Transcriptional Circuitry of Human Inflammatory Response and Autoimmunity.Morphological restructuring of myocardium during the early phase of experimental diabetes mellitus.MicroRNA-495 inhibits the high glucose-induced inflammation, differentiation and extracellular matrix accumulation of cardiac fibroblasts through downregulation of NOD1.

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Targeted inhibition of calpain reduces myocardial hypertrophy and fibrosis in mouse models of type 1 diabetes

http://www.wikidata.org/entity/Q35404816

description

2011 nî lūn-bûn

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2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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Targeted inhibition of calpain ...... ouse models of type 1 diabetes

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Targeted inhibition of calpain ...... ouse models of type 1 diabetes

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Targeted inhibition of calpain ...... ouse models of type 1 diabetes

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Targeted inhibition of calpain ...... ouse models of type 1 diabetes

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David Hill

http://www.w3.org/2001/XMLSchema#string

E Dale Abel

http://www.w3.org/2001/XMLSchema#string

Huaqing Zhu

http://www.w3.org/2001/XMLSchema#string

J Malcolm Arnold

http://www.w3.org/2001/XMLSchema#string

Jian Ma

http://www.w3.org/2001/XMLSchema#string

Manpreet Singh

http://www.w3.org/2001/XMLSchema#string

Peter A Greer

http://www.w3.org/2001/XMLSchema#string

Tianqing Peng

http://www.w3.org/2001/XMLSchema#string

Ying Li

http://www.w3.org/2001/XMLSchema#string

P2860

Calpain contributes to silica-induced IkB-a degradation and nuclear factor-kB activation

Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart

Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin

The calpain system

Structure, activation, and biology of calpain

Disruption of the murine calpain small subunit gene, Capn4: calpain is essential for embryonic development but not for cell growth and division

Over-expression of calpastatin inhibits calpain activation and attenuates myocardial dysfunction during endotoxaemia

Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload.

Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy.

Deficiency of rac1 blocks NADPH oxidase activation, inhibits endoplasmic reticulum stress, and reduces myocardial remodeling in a mouse model of type 1 diabetes.

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2985-2994

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10.2337/DB10-1333

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11

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60

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2011-09-12T00:00:00Z

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51641324

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21911754

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type-1 diabetes

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3198063

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