Transgenic overexpression of the transcription factor Nkx6.1 in β-cells of mice does not increase β-cell proliferation, β-cell mass, or improve glucose clearance.
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Generation of β cells from human pluripotent stem cells: are we there yet?Derivation of insulin-producing beta-cells from human pluripotent stem cellsNkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptorsNkx6.1 is essential for maintaining the functional state of pancreatic beta cells.Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity.Postnatal β-cell proliferation and mass expansion is dependent on the transcription factor Nkx6.1.Aurora Kinase A is critical for the Nkx6.1 mediated β-cell proliferation pathway.The Transcription Factor Nfatc2 Regulates β-Cell Proliferation and Genes Associated with Type 2 Diabetes in Mouse and Human Islets.Inactivation of the dual Bmp/Wnt inhibitor Sostdc1 enhances pancreatic islet function.Pdx-1 activates islet α- and β-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2.The diabetes gene Hhex maintains δ-cell differentiation and islet function.Elevation of transcription factor Islet-1 levels in vivo increases β-cell function but not β-cell massDevelopment and regeneration in the endocrine pancreasNkx6.1-mediated insulin secretion and β-cell proliferation is dependent on upregulation of c-Fos.
P2860
Q26823732-C36CFDA9-4871-4A60-BE0A-1BDB5A93748CQ27011814-65D5C3EC-CF58-4DB2-AF3D-415E40ECE4B9Q28578613-450E6C13-D85F-4BF5-B5D3-439C61157233Q33756959-03E6B3E2-B628-474B-AC7F-A87E8BC8F0B4Q34574951-A3882715-1FF0-4A34-83C0-1573542D5773Q35114510-8B43C7EB-8BE7-4FB9-B132-F15E907E3827Q36106621-CBDB12B1-B81D-4551-943A-CCE20396B2F9Q36217634-EBE337BA-67DE-408A-9F64-6D86447BDF08Q36309205-BE17B78C-7BDD-4D5C-9B0D-71370C5C1E65Q37264382-C6B71A5F-044C-4AF6-AF92-AD7FD0880C1CQ37729757-8D360F54-B550-44F5-8821-99501E9AED8BQ38325204-080BE69F-9605-417D-A9CF-2510D6743181Q42720344-88B90E4D-1BFA-4FF5-98D7-5C23C0CBBB23Q45897692-8A5E989B-F6EE-42FC-8781-CA2EB76C440F
P2860
Transgenic overexpression of the transcription factor Nkx6.1 in β-cells of mice does not increase β-cell proliferation, β-cell mass, or improve glucose clearance.
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2011 nî lūn-bûn
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2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年論文
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2011年論文
@zh-hant
2011年論文
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2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Transgenic overexpression of t ...... or improve glucose clearance.
@ast
Transgenic overexpression of t ...... or improve glucose clearance.
@en
type
label
Transgenic overexpression of t ...... or improve glucose clearance.
@ast
Transgenic overexpression of t ...... or improve glucose clearance.
@en
prefLabel
Transgenic overexpression of t ...... or improve glucose clearance.
@ast
Transgenic overexpression of t ...... or improve glucose clearance.
@en
P2093
P2860
P356
P1476
Transgenic overexpression of t ...... , or improve glucose clearance
@en
P2093
Almira J Yang
Fabrizio Thorel
Maike Sander
P2860
P304
P356
10.1210/ME.2011-1010
P577
2011-09-29T00:00:00Z