Transgenic overexpression of the transcription factor Nkx6.1 in β-cells of mice does not increase β-cell proliferation, β-cell mass, or improve glucose clearance.

Transgenic overexpression of the transcription factor Nkx6.1 in β-cells of mice does not increase β-cell proliferation, β-cell mass, or improve glucose clearance.

Item
http://www.wikidata.org/entity/Q35416441
Generation of β cells from human pluripotent stem cells: are we there yet?Derivation of insulin-producing beta-cells from human pluripotent stem cellsNkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptorsNkx6.1 is essential for maintaining the functional state of pancreatic beta cells.Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity.Postnatal β-cell proliferation and mass expansion is dependent on the transcription factor Nkx6.1.Aurora Kinase A is critical for the Nkx6.1 mediated β-cell proliferation pathway.The Transcription Factor Nfatc2 Regulates β-Cell Proliferation and Genes Associated with Type 2 Diabetes in Mouse and Human Islets.Inactivation of the dual Bmp/Wnt inhibitor Sostdc1 enhances pancreatic islet function.Pdx-1 activates islet α- and β-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2.The diabetes gene Hhex maintains δ-cell differentiation and islet function.Elevation of transcription factor Islet-1 levels in vivo increases β-cell function but not β-cell massDevelopment and regeneration in the endocrine pancreasNkx6.1-mediated insulin secretion and β-cell proliferation is dependent on upregulation of c-Fos.
P2860

Transgenic overexpression of the transcription factor Nkx6.1 in β-cells of mice does not increase β-cell proliferation, β-cell mass, or improve glucose clearance.

Item
http://www.wikidata.org/entity/Q35416441
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2011 nî lūn-bûn
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2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年论文
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name
Transgenic overexpression of t ...... or improve glucose clearance.
@ast
Transgenic overexpression of t ...... or improve glucose clearance.
@en
type
label
Transgenic overexpression of t ...... or improve glucose clearance.
@ast
Transgenic overexpression of t ...... or improve glucose clearance.
@en
prefLabel
Transgenic overexpression of t ...... or improve glucose clearance.
@ast
Transgenic overexpression of t ...... or improve glucose clearance.
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P5875
P698
P921
P932
P356
P1433
P1476
Transgenic overexpression of t ...... , or improve glucose clearance
@en
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P5875
P698
P921
P932