about
The transcription factor Rfx3 regulates beta-cell differentiation, function, and glucokinase expressionJunctional communication of pancreatic beta cells contributes to the control of insulin secretion and glucose toleranceFoxa2 is required for the differentiation of pancreatic alpha-cellsPancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in miceInsulin and IGF1 receptors are essential for XX and XY gonadal differentiation and adrenal development in miceArgonaute2 mediates compensatory expansion of the pancreatic β cell.An essential role for insulin and IGF1 receptors in regulating sertoli cell proliferation, testis size, and FSH action in miceConversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell lossActivation of the Reg family genes by pancreatic-specific IGF-I gene deficiency and after streptozotocin-induced diabetes in mouse pancreasDiabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers.Insulin and Glucagon: Partners for Life.Defining the cell lineages of the islets of Langerhans using transgenic mice.Targeting GLP-1 receptors for repeated magnetic resonance imaging differentiates graded losses of pancreatic beta cells in mice.Context-specific α- to-β-cell reprogramming by forced Pdx1 expression.Connective tissue growth factor modulates adult β-cell maturity and proliferation to promote β-cell regeneration in miceTransgenic overexpression of the transcription factor Nkx6.1 in β-cells of mice does not increase β-cell proliferation, β-cell mass, or improve glucose clearance.Multimodal image coregistration and inducible selective cell ablation to evaluate imaging ligandsEmbryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression.Lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient NOD-scid IL-2rg(null) RIP-DTR mice engrafted with human islets.The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion.Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine β-Cells.Nogo-A downregulation improves insulin secretion in mice.UCP2 regulates the glucagon response to fasting and starvationStress-impaired transcription factor expression and insulin secretion in transplanted human islets.Blockade of glucagon signaling prevents or reverses diabetes onset only if residual β-cells persist.Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice.Cell type-specific deletion in mice reveals roles for PAS kinase in insulin and glucagon productionExperimental models of beta-cell regeneration.Loss of prohibitin induces mitochondrial damages altering β-cell function and survival and is responsible for gradual diabetes development.Genes controlling pancreas ontogeny.Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin.Transgenic and other experimental models of pancreas and islet damage.β-cell regeneration: the pancreatic intrinsic faculty.Stress-induced adaptive islet cell identity changesRegeneration of pancreatic insulin-producing cells by in situ adaptive cell conversion.Pancreatic α Cell-Derived Glucagon-Related Peptides Are Required for β Cell Adaptation and Glucose Homeostasis.A standardized method for in vivo mouse pancreas imaging and semiquantitative β cell mass measurement by dual isotope SPECT.The zinc finger protein ZBTB20 regulates transcription of fructose-1,6-bisphosphatase 1 and β cell function in mice.Increasing uncoupling protein-2 in pancreatic beta cells does not alter glucose-induced insulin secretion but decreases production of reactive oxygen species.LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia
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P50
description
Forscher
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chercheur
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investigador
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researcher
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ricercatore
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wetenschapper
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研究者
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name
Herrera PL
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Herrera PL
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Herrera PL
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Pedro Luis Herrera
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Herrera PL
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Herrera PL
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Herrera PL
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Pedro Luis Herrera
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Pedro Luis Herrera Merino
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Herrera PL
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Herrera PL
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Herrera PL
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Pedro Luis Herrera
@en
P106
P31
P496
0000-0003-0771-9504