Immunochemical detection of cytochrome P450 enzymes in liver microsomes of 27 cynomolgus monkeys.

Immunochemical detection of cytochrome P450 enzymes in liver microsomes of 27 cynomolgus monkeys.

Item
http://www.wikidata.org/entity/Q35429761
Qualitative de novo analysis of full length cDNA and quantitative analysis of gene expression for common marmoset (Callithrix jacchus) transcriptomes using parallel long-read technology and short-read sequencingA new approach to predicting human hepatic clearance of CYP3A4 substrates using monkey pharmacokinetic data.Immunochemical detection of cytochrome P450 enzymes in small intestine microsomes of male and female untreated juvenile cynomolgus monkeysImmunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine.Marmoset cytochrome P450 2D8 in livers and small intestines metabolizes typical human P450 2D6 substrates, metoprolol, bufuralol and dextromethorphan.Hepatic expression of cytochrome P450 enzymes in non-human primate species.Comprehensive evaluation of liver microsomal cytochrome P450 3A (CYP3A) inhibition: comparison of cynomolgus monkey and human.Identification of putative substrates for cynomolgus monkey cytochrome P450 2C8 by substrate depletion assays with 22 human P450 substrates and inhibitors.Similar substrate specificity of cynomolgus monkey cytochrome P450 2C19 to reported human P450 2C counterpart enzymes by evaluation of 89 drug clearances.Age-related changes of hepatic clearances of cytochrome P450 probes, midazolam and R-/S-warfarin in combination with caffeine, omeprazole and metoprolol in cynomolgus monkeys using in vitro-in vivo correlation.Marmoset cytochrome P450 2J2 mainly expressed in small intestines and livers effectively metabolizes human P450 2J2 probe substrates, astemizole and terfenadine.A New Marmoset P450 4F12 Enzyme Expressed in Small Intestines and Livers Efficiently Metabolizes Antihistaminic Drug Ebastine.Monkey liver cytochrome P450 2C9 is involved in caffeine 7-N-demethylation to form theophylline.R-warfarin clearances from plasma associated with polymorphic cytochrome P450 2C19 and simulated by individual physiologically based pharmacokinetic models for 11 cynomolgus monkeys.Characterization of feline cytochrome P450 2B6.Characterization of intestinal and hepatic P450 enzymes in cynomolgus monkeys with typical substrates and inhibitors for human P450 enzymes.
P2860

Immunochemical detection of cytochrome P450 enzymes in liver microsomes of 27 cynomolgus monkeys.

Item
http://www.wikidata.org/entity/Q35429761
description
2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Immunochemical detection of cy ...... omes of 27 cynomolgus monkeys.
@ast
Immunochemical detection of cy ...... omes of 27 cynomolgus monkeys.
@en
type
label
Immunochemical detection of cy ...... omes of 27 cynomolgus monkeys.
@ast
Immunochemical detection of cy ...... omes of 27 cynomolgus monkeys.
@en
prefLabel
Immunochemical detection of cy ...... omes of 27 cynomolgus monkeys.
@ast
Immunochemical detection of cy ...... omes of 27 cynomolgus monkeys.
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P1476
P2093
P2860
P304
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P356
P407
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P478
P50
P577
P5875
P698
P932
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P1433
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Immunochemical detection of cy ...... somes of 27 cynomolgus monkeys
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P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P932