Astrocytes carrying the superoxide dismutase 1 (SOD1G93A) mutation induce wild-type motor neuron degeneration in vivo. - Wikidata - wikimedia - TriplyDB

Astrocytes carrying the superoxide dismutase 1 (SOD1G93A) mutation induce wild-type motor neuron degeneration in vivo.

Astrocytes carrying the superoxide dismutase 1 (SOD1G93A) mutation induce wild-type motor neuron degeneration in vivo.

http://www.wikidata.org/entity/Q35471228

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Astrocytes As the Main Players in Primary Degenerative Disorders of the Human Central Nervous System Transplantation of stem cell-derived astrocytes for the treatment of amyotrophic lateral sclerosis and spinal cord injury Astrocytes conspire with neurons during progression of neurological disease Glia: an emerging target for neurological disease therapy Induced pluripotent stem cells from ALS patients for disease modeling Therapeutic neuroprotective agents for amyotrophic lateral sclerosis Therapeutic applications of mesenchymal stem cells for amyotrophic lateral sclerosis.A comprehensive library of familial human amyotrophic lateral sclerosis induced pluripotent stem cells Neuronal expression of Fig4 is both necessary and sufficient to prevent spongiform neurodegeneration.Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis.Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in rats Adeno-associated virus-delivered artificial microRNA extends survival and delays paralysis in an amyotrophic lateral sclerosis mouse model.Fast skeletal muscle troponin activator tirasemtiv increases muscle function and performance in the B6SJL-SOD1G93A ALS mouse model Human glial progenitor engraftment and gene expression is independent of the ALS environment A Refined Bead-Free Method to Identify Astrocytic Exosomes in Primary Glial Cultures and Blood Plasma Necroptosis drives motor neuron death in models of both sporadic and familial ALS.Focal transplantation of human iPSC-derived glial-rich neural progenitors improves lifespan of ALS mice Enhanced GLT-1 mediated glutamate uptake and migration of primary astrocytes directed by fibronectin-coated electrospun poly-L-lactic acid fibers.Low-frequency magnetic fields do not aggravate disease in mouse models of Alzheimer's disease and amyotrophic lateral sclerosis.Human-derived neural progenitors functionally replace astrocytes in adult mice.Neuron-specific antioxidant OXR1 extends survival of a mouse model of amyotrophic lateral sclerosis Wnt Signaling Alteration in the Spinal Cord of Amyotrophic Lateral Sclerosis Transgenic Mice: Special Focus on Frizzled-5 Cellular Expression Pattern The Regulatory Machinery of Neurodegeneration in In Vitro Models of Amyotrophic Lateral Sclerosis.Stem cell therapy for amyotrophic lateral sclerosis Entorhinal cortical neurons are the primary targets of FUS mislocalization and ubiquitin aggregation in FUS transgenic rats.Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis Amyotrophic lateral sclerosis and organ donation: is there risk of disease transmission?Intricate interplay between astrocytes and motor neurons in ALS.Genome-Scale Mapping of MicroRNA Signatures in Human Embryonic Stem Cell Neurogenesis.An Engraftable Human Embryonic Stem Cell Neuronal Lineage-Specific Derivative Retains Embryonic Chromatin Plasticity for Scale-Up CNS Regeneration Reverse engineering human neurodegenerative disease using pluripotent stem cell technology.Mutant copper-zinc superoxide dismutase (SOD1) induces protein secretion pathway alterations and exosome release in astrocytes: implications for disease spreading and motor neuron pathology in amyotrophic lateral sclerosis Phenotypic transition of microglia into astrocyte-like cells associated with disease onset in a model of inherited ALS Widespread spinal cord transduction by intrathecal injection of rAAV delivers efficacious RNAi therapy for amyotrophic lateral sclerosis.PACAP signaling exerts opposing effects on neuroprotection and neuroinflammation during disease progression in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis Can regional spreading of amyotrophic lateral sclerosis motor symptoms be explained by prion-like propagation?Astrocyte signaling and neurodegeneration: new insights into CNS disorders.The multifaceted role of glial cells in amyotrophic lateral sclerosis.Cellular therapy to target neuroinflammation in amyotrophic lateral sclerosis.Amyotrophic lateral sclerosis and skeletal muscle: an update.

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Astrocytes carrying the superoxide dismutase 1 (SOD1G93A) mutation induce wild-type motor neuron degeneration in vivo.

http://www.wikidata.org/entity/Q35471228

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2011 nî lūn-bûn

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2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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Astrocytes carrying the supero ...... r neuron degeneration in vivo.

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Astrocytes carrying the supero ...... r neuron degeneration in vivo.

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Astrocytes carrying the supero ...... r neuron degeneration in vivo.

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Angelo C Lepore

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Colin O'Banion

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Nicholas J Maragakis

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Sarah E Kraig

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Sophia T Papadeas

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P2860

Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease

Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

Microglia-specific localisation of a novel calcium binding protein, Iba1

Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

Unraveling the mechanisms involved in motor neuron degeneration in ALS

Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

Minocycline treatment reduces delayed oligodendrocyte death, attenuates axonal dieback, and improves functional outcome after spinal cord injury.

Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS).

Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis.

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