Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death - Wikidata - wikimedia - TriplyDB

Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death

Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death

http://www.wikidata.org/entity/Q35484581

about

Exosomes: vehicles for the transfer of toxic proteins associated with neurodegenerative diseases?The chaperone-like protein 14-3-3η interacts with human α-synuclein aggregation intermediates rerouting the amyloidogenic pathway and reducing α-synuclein cellular toxicity Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease Definition of a molecular pathway mediating α-synuclein neurotoxicity α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation Gut Feelings About α-Synuclein in Gastrointestinal Biopsies: Biomarker in the Making?The Unfolded Protein Response and the Role of Protein Disulfide Isomerase in Neurodegeneration Mechanism of Anti-α-Synuclein Immunotherapy The role of macropinocytosis in the propagation of protein aggregation associated with neurodegenerative diseases Disease-modifying therapeutic directions for Lewy-Body dementias Dysregulation of glutathione homeostasis in neurodegenerative diseases The complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's disease Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease Self-propagation of pathogenic protein aggregates in neurodegenerative diseases Features of alpha-synuclein that could explain the progression and irreversibility of Parkinson's disease Proteolytic clearance of extracellular α-synuclein as a new therapeutic approach against Parkinson disease Neurodegenerative diseases: expanding the prion concept Vaccination strategies for Parkinson disease: induction of a swift attack or raising tolerance?Prion-like properties of Tau protein: the importance of extracellular Tau as a therapeutic target Inflammation and α-synuclein's prion-like behavior in Parkinson's disease--is there a link?Treating Parkinson's disease in the 21st century: can stem cell transplantation compete?M1 and M2 immune activation in Parkinson's Disease: Foe and ally?Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies.Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies.The Synaptic Function of α-Synuclein Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes.More than a Rumor Spreads in Parkinson's Disease The contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's disease Dysregulation of autophagy and mitochondrial function in Parkinson's disease Seeking a mechanism for the toxicity of oligomeric α-synuclein Spreading of pathology in neurodegenerative diseases: a focus on human studies Alpha-synuclein spreading in Parkinson's disease Cellular biomechanics of central nervous system injury Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synuclein Alpha-synuclein and tau: teammates in neurodegeneration?Distinct α-synuclein strains differentially promote tau inclusions in neurons Deficient Wnt signalling triggers striatal synaptic degeneration and impaired motor behaviour in adult mice Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice

P2860

Q21129257-E36F5765-77B9-4C23-ADFE-2181479DA89A Q24298721-E84DBC35-C442-4871-9E3D-8B9AEA3B43E5 Q24320103-5FEBF580-DF23-4718-9D34-C50054A2DD3A Q24609725-34EDB98A-FD96-4B74-80B2-FE26F0EEADF5 Q26269832-73F26E26-9924-4405-B79A-C47B6918F1BC Q26269838-B0A63A57-A8AC-4FA9-A6BD-A17FAC41BBD1 Q26769620-B0EF9F53-7A20-49A9-B142-85CC4FE586D3 Q26771343-4BF182AB-28B7-4D32-8327-3FDE72087FD8 Q26772943-AB4B9A67-5B1E-4175-B69E-2F1540378074 Q26777240-4E42FD28-BDD8-449B-A7B0-9F2CC0B2B8E7 Q26782907-667A85B8-20CF-49DE-A9A7-562DF9BC3648 Q26822726-BEED47C7-F788-4060-92C9-20805DA7CA04 Q26853537-E178D54A-1380-4810-88FF-A61295CCCD45 Q26853610-E9776DF0-B3F0-46B4-86C5-E8DC8FE06807 Q26996441-391713E5-6B05-467D-B99B-D45DC9D3180E Q26996688-5727CC0D-6026-4E10-BD66-21BEB19145B8 Q27005843-C960CCC8-F13A-41FC-A515-194005C6F47D Q27011744-3424165C-254D-46F4-918E-11C1DD3B9B6E Q27015811-FC953CFB-CAD9-4E2F-8847-822FFFF0A710 Q27021159-033D96CB-F9E1-4F6A-B692-1EE0D1D037B8 Q27022728-E2567213-C37F-4952-B773-9B9653DED649 Q27024152-F2E030F5-3923-40BE-B60C-F408A7EC948F Q27024667-377D2C9F-A639-4877-B1C6-9505ACD63D1E Q27300819-10BB6BF7-EB92-4BF5-AD91-949A8DBADFB6 Q27322513-9423B6AF-3AFB-430E-ABDB-EF9EA62564E7 Q27686837-D31EB9BD-7A76-424B-A39A-D945680A8A36 Q27694711-4DFF5760-6190-4C94-8506-2A4AA4F2819D Q27932080-CF5DCD86-510C-473D-B57E-51763E814908 Q28066571-B4F945B0-3200-45D1-9A85-D62C1ADE9705 Q28068464-C624C085-7869-4D16-85A8-2CA852D06C34 Q28071890-01FB72E9-78BC-48C3-B9C0-1A00F90807C5 Q28080551-7FF17DD3-8A0E-4A7A-99A7-0942A55F98CE Q28082279-9AAFA830-9487-4FAB-B98C-D619D238CD14 Q28082548-31465796-0185-47A6-AF76-27D7CA8FB4CA Q28085115-CF80B59B-02B5-4BC7-BD9C-466A62910037 Q28117589-2B8408B1-D13F-4BA8-8FDB-64E56EDF4F0A Q28250508-A96C04C6-AC38-488B-AE21-8D21EE335DBE Q28293967-9D998800-FAEE-403F-A181-7AE743F0998B Q28591970-4B90575E-2A93-4E20-A889-312A782A23B6 Q29620597-60F18FE4-D9E1-404B-9F08-2BE34A9EE7D8

P2860

Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death

http://www.wikidata.org/entity/Q35484581

description

2011 nî lūn-bûn

@nan

2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Exogenous α-synuclein fibrils ...... c dysfunction and neuron death

@ast

Exogenous α-synuclein fibrils ...... c dysfunction and neuron death

@en

type

label

Exogenous α-synuclein fibrils ...... c dysfunction and neuron death

@ast

Exogenous α-synuclein fibrils ...... c dysfunction and neuron death

@en

prefLabel

Exogenous α-synuclein fibrils ...... c dysfunction and neuron death

@ast

Exogenous α-synuclein fibrils ...... c dysfunction and neuron death

@en

P1433

Q35484581-08AF9043-6B21-4224-B31B-9E4015170821

P1476

Q35484581-D3726873-0287-4174-AE04-FF4F2043C1AB

P2093

Q35484581-56FF7C82-FC39-45DB-B22B-82E44B5F939A

Q35484581-58F538AB-BC8A-4FF3-BDFA-EDB63A29319F

Q35484581-64A76940-7268-4FA5-B8D4-B1EE794A2D99

Q35484581-8850EDF3-8A35-42B6-BC98-78E1924A3774

Q35484581-8ADE4037-4308-4A4E-B051-4AE76CDB5A46

Q35484581-A578BBDE-A51B-4376-8A69-9B05D42F24EA

Q35484581-E7914FEC-80F0-4676-9561-BF6561844FBA

Q35484581-EEE6A928-DE44-4AFE-8F9D-382EB6129E6B

P2860

Q35484581-0746A1FF-AB8E-463A-A0B6-93B072AC4C36

Q35484581-1DB2EA30-15A2-4477-ADD4-5BBC67C8EEC9

Q35484581-23D03B5B-E9D2-4C90-8FFF-1B4C719BA34B

Q35484581-27870089-BD60-4250-91CD-7F4902BBEAE1

Q35484581-2A0B2B94-0EDB-468C-B3E5-6735FCE97FED

Q35484581-2A81367D-D7B1-4960-B0DA-E5F79896DADA

Q35484581-34C2382C-0B5C-4B63-86CC-7DC839AC4BCB

Q35484581-3CE9951B-D7FE-4892-8464-75709C1DC6BA

Q35484581-3D0E1DD9-BDE8-4D9C-B29C-67731AE8215F

Q35484581-3EC2C754-A607-499B-95FC-8DC7BDE1CAA5

P304

Q35484581-D68B7617-7607-4A67-9498-C3044CA3BEED

P31

Q35484581-6C898196-C315-4986-8F3A-88E1E56E978F

P356

Q35484581-2D01E7AE-2C48-4D9A-AF8A-15A405A6300F

P407

Q35484581-0804B8A0-ABC5-4889-8C0E-0B4E40F3E7E7

P433

Q35484581-C65D860E-E7D5-4F43-BC23-6926AC54E5A1

P478

Q35484581-57F6806F-793A-45F0-8FDB-F2F8F91BAD6B

P50

Q35484581-C0B50D23-186B-4758-B4AD-29B692F248EF

P577

Q35484581-792B576B-3161-4F28-8F54-78B5AB99CD24

P5875

Q35484581-3F896353-A8E0-4B32-B0CE-AD2674C28236

P698

Q35484581-0D8A24F5-7BF0-49CD-BD59-166EF43D0178

P921

Q35484581-695e786a-b05f-473c-8103-f62b22924352

Q35484581-AF4AD626-3DE7-4897-8378-03ECE22311FC

P932

Q35484581-05607AA3-7094-42B2-BD29-5C16596EFA42

P356

J.NEURON.2011.08.033

P1433

P1476

Exogenous α-synuclein fibrils ...... c dysfunction and neuron death

@en

P2093

Anna Stieber

http://www.w3.org/2001/XMLSchema#string

David F Meaney

http://www.w3.org/2001/XMLSchema#string

Dawn M Riddle

http://www.w3.org/2001/XMLSchema#string

Kelvin C Luk

http://www.w3.org/2001/XMLSchema#string

Laura A Volpicelli-Daley

http://www.w3.org/2001/XMLSchema#string

Selcuk A Tanik

http://www.w3.org/2001/XMLSchema#string

Tapan P Patel

http://www.w3.org/2001/XMLSchema#string

Virginia M-Y Lee

http://www.w3.org/2001/XMLSchema#string

P2860

Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells.

Transmission and spreading of tauopathy in transgenic mouse brain

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

alpha-Synuclein locus triplication causes Parkinson's disease

Neuropathological stageing of Alzheimer-related changes

Staging of brain pathology related to sporadic Parkinson's disease

Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease

αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction

Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons

P304

57-71

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1016/J.NEURON.2011.08.033

http://www.w3.org/2001/XMLSchema#string

P407

P433

1

http://www.w3.org/2001/XMLSchema#string

P478

72

http://www.w3.org/2001/XMLSchema#string

P50

John Q. Trojanowski

P577

2011-10-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

51701960

http://www.w3.org/2001/XMLSchema#string

P698

21982369

http://www.w3.org/2001/XMLSchema#string

P921

P932

3204802

http://www.w3.org/2001/XMLSchema#string