Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL.
about
Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapyNovel Insights into the Roles of Rho Kinase in CancerThe double face of Morgana in tumorigenesisROCK1 deficiency enhances protective effects of antioxidants against apoptosis and cell detachmentA high-content EMT screen identifies multiple receptor tyrosine kinase inhibitors with activity on TGFβ receptorRho kinase proteins display aberrant upregulation in vascular tumors and contribute to vascular tumor growth.Class I(A) PI3Kinase regulatory subunit, p85α, mediates mast cell development through regulation of growth and survival related genesIdentification of regulators of polyploidization presents therapeutic targets for treatment of AMKLROCK1 as a novel prognostic marker in vulvar cancerOncogenic Kit signals on endolysosomes and endoplasmic reticulum are essential for neoplastic mast cell proliferation.Role of intracellular tyrosines in activating KIT-induced myeloproliferative diseaseRegulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven LeukemogenesisTargeting phosphatidylinositol-3-kinase pathway for the treatment of Philadelphia-negative myeloproliferative neoplasms.p85β regulatory subunit of class IA PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis.Mastocytosis: a mutated KIT receptor induced myeloproliferative disorderRole of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT.ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53.RhoA modulates functional and physical interaction between ROCK1 and Erk1/2 in selenite-induced apoptosis of leukaemia cells.Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment.ROCK1 via LIM kinase regulates growth, maturation and actin based functions in mast cells.Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress.Pak and Rac GTPases promote oncogenic KIT-induced neoplasms.Dual inhibition of AKT/FLT3-ITD by A674563 overcomes FLT3 ligand-induced drug resistance in FLT3-ITD positive AML.Rho kinases in cardiovascular physiology and pathophysiology: the effect of fasudil.Role of Rho kinases in abnormal and normal hematopoiesis.Rho GTPases modulate malignant transformation of tumor cells.Kinase signaling and targeted therapy for primary myelofibrosis.LIM kinases: cofilin and beyond.Genomic landscape of gastric cancer: molecular classification and potential targets.Mtss1 is a critical epigenetically regulated tumor suppressor in CML.GSK-3Beta-Dependent Activation of GEF-H1/ROCK Signaling Promotes LPS-Induced Lung Vascular Endothelial Barrier Dysfunction and Acute Lung Injury.Fasudil, a clinically safe ROCK inhibitor, decreases disease burden in a Cbl/Cbl-b deficiency-driven murine model of myeloproliferative disorders.Internal tandem duplication mutations in FLT3 gene augment chemotaxis to Cxcl12 protein by blocking the down-regulation of the Rho-associated kinase via the Cxcl12/Cxcr4 signaling axis.Targeting Rho associated kinases in leukemia and myeloproliferative neoplasms.ROCKII Ser1366 phosphorylation reflects the activation status.Targeting few to help hundreds: JAK, MAPK and ROCK pathways as druggable targets in atypical chronic myeloid leukemia.Fasudil inhibits proliferation and migration of Hep-2 laryngeal carcinoma cells.
P2860
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P2860
Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL.
description
2011 nî lūn-bûn
@nan
2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Rho kinase regulates the survi ...... rms of KIT, FLT3, and BCR-ABL.
@ast
Rho kinase regulates the survi ...... rms of KIT, FLT3, and BCR-ABL.
@en
type
label
Rho kinase regulates the survi ...... rms of KIT, FLT3, and BCR-ABL.
@ast
Rho kinase regulates the survi ...... rms of KIT, FLT3, and BCR-ABL.
@en
prefLabel
Rho kinase regulates the survi ...... rms of KIT, FLT3, and BCR-ABL.
@ast
Rho kinase regulates the survi ...... rms of KIT, FLT3, and BCR-ABL.
@en
P2093
P2860
P1433
P1476
Rho kinase regulates the survi ...... rms of KIT, FLT3, and BCR-ABL.
@en
P2093
Andrew M Stern
Baskar Ramdas
Charles B Goodwin
Emily Sims
Fabiola Traina
H Scott Boswell
Jianjian Shi
John D Crispino
P2860
P304
P356
10.1016/J.CCR.2011.07.016
P577
2011-09-01T00:00:00Z