Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL. - Wikidata - wikimedia - TriplyDB

Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL.

Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL.

http://www.wikidata.org/entity/Q35513750

about

Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy Novel Insights into the Roles of Rho Kinase in Cancer The double face of Morgana in tumorigenesis ROCK1 deficiency enhances protective effects of antioxidants against apoptosis and cell detachment A high-content EMT screen identifies multiple receptor tyrosine kinase inhibitors with activity on TGFβ receptor Rho kinase proteins display aberrant upregulation in vascular tumors and contribute to vascular tumor growth.Class I(A) PI3Kinase regulatory subunit, p85α, mediates mast cell development through regulation of growth and survival related genes Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL ROCK1 as a novel prognostic marker in vulvar cancer Oncogenic Kit signals on endolysosomes and endoplasmic reticulum are essential for neoplastic mast cell proliferation.Role of intracellular tyrosines in activating KIT-induced myeloproliferative disease Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis Targeting phosphatidylinositol-3-kinase pathway for the treatment of Philadelphia-negative myeloproliferative neoplasms.p85β regulatory subunit of class IA PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis.Mastocytosis: a mutated KIT receptor induced myeloproliferative disorder Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT.ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53.RhoA modulates functional and physical interaction between ROCK1 and Erk1/2 in selenite-induced apoptosis of leukaemia cells.Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment.ROCK1 via LIM kinase regulates growth, maturation and actin based functions in mast cells.Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress.Pak and Rac GTPases promote oncogenic KIT-induced neoplasms.Dual inhibition of AKT/FLT3-ITD by A674563 overcomes FLT3 ligand-induced drug resistance in FLT3-ITD positive AML.Rho kinases in cardiovascular physiology and pathophysiology: the effect of fasudil.Role of Rho kinases in abnormal and normal hematopoiesis.Rho GTPases modulate malignant transformation of tumor cells.Kinase signaling and targeted therapy for primary myelofibrosis.LIM kinases: cofilin and beyond.Genomic landscape of gastric cancer: molecular classification and potential targets.Mtss1 is a critical epigenetically regulated tumor suppressor in CML.GSK-3Beta-Dependent Activation of GEF-H1/ROCK Signaling Promotes LPS-Induced Lung Vascular Endothelial Barrier Dysfunction and Acute Lung Injury.Fasudil, a clinically safe ROCK inhibitor, decreases disease burden in a Cbl/Cbl-b deficiency-driven murine model of myeloproliferative disorders.Internal tandem duplication mutations in FLT3 gene augment chemotaxis to Cxcl12 protein by blocking the down-regulation of the Rho-associated kinase via the Cxcl12/Cxcr4 signaling axis.Targeting Rho associated kinases in leukemia and myeloproliferative neoplasms.ROCKII Ser1366 phosphorylation reflects the activation status.Targeting few to help hundreds: JAK, MAPK and ROCK pathways as druggable targets in atypical chronic myeloid leukemia.Fasudil inhibits proliferation and migration of Hep-2 laryngeal carcinoma cells.

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Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL.

http://www.wikidata.org/entity/Q35513750

description

2011 nî lūn-bûn

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2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Rho kinase regulates the survi ...... rms of KIT, FLT3, and BCR-ABL.

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Rho kinase regulates the survi ...... rms of KIT, FLT3, and BCR-ABL.

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Rho kinase regulates the survi ...... rms of KIT, FLT3, and BCR-ABL.

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Rho kinase regulates the survi ...... rms of KIT, FLT3, and BCR-ABL.

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Rho kinase regulates the survi ...... rms of KIT, FLT3, and BCR-ABL.

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J.CCR.2011.07.016

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Rho kinase regulates the survi ...... rms of KIT, FLT3, and BCR-ABL.

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Andrew M Stern

http://www.w3.org/2001/XMLSchema#string

Baskar Ramdas

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Charles B Goodwin

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Emily Sims

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Fabiola Traina

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H Scott Boswell

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Jianjian Shi

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John D Crispino

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Lei Wei

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Peilin Ma

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P2860

Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop

Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase

Rocks: multifunctional kinases in cell behaviour

Constitutive c-jun N-terminal kinase activity in acute myeloid leukemia derives from Flt3 and affects survival and proliferation

Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)

Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2

The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton

Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study.

Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors

Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing

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10.1016/J.CCR.2011.07.016

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