Heat shock transcription factor 1 is a key determinant of HCC development by regulating hepatic steatosis and metabolic syndrome.
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Tissue- and Serum-Associated Biomarkers of Hepatocellular CarcinomaPleiotropic role of HSF1 in neoplastic transformationHeat-shock factor 2 is a suppressor of prostate cancer invasion.Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update14-3-3σ induces heat shock protein 70 expression in hepatocellular carcinoma.High level of HSF1 associates with aggressive endometrial carcinoma and suggests potential for HSP90 inhibitors.Role of insulin receptor substrates in the progression of hepatocellular carcinoma.Hsp90 modulates PPARγ activity in a mouse model of nonalcoholic fatty liver disease.HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers.Upregulation of heat shock factor 1 transcription activity is associated with hepatocellular carcinoma progression.The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy.HSF1 regulation of β-catenin in mammary cancer cells through control of HuR/elavL1 expression.Suppression of the HSF1-mediated proteotoxic stress response by the metabolic stress sensor AMPKFBXW7 modulates cellular stress response and metastatic potential through HSF1 post-translational modification.MEK guards proteome stability and inhibits tumor-suppressive amyloidogenesis via HSF1.Proteotoxic stress of cancer: implication of the heat-shock response in oncogenesis.Defective heat shock factor 1 inhibits the growth of fibrosarcoma derived from simian virus 40/T antigen‑transformed MEF cells.Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesisOverexpression of MAPK15 in gastric cancer is associated with copy number gain and contributes to the stability of c-Jun.Heat shock factor Hsf1 cooperates with ErbB2 (Her2/Neu) protein to promote mammary tumorigenesis and metastasis.HSF1: Guardian of Proteostasis in CancerHepatitis C virus-related hepatocellular carcinoma: An insight into molecular mechanisms and therapeutic strategiesHeat shock factor-1 knockout enhances cholesterol 7α-hydroxylase (CYP7A1) and multidrug transporter (MDR1) gene expressions to attenuate atherosclerosis.PSMD10/gankyrin induces autophagy to promote tumor progression through cytoplasmic interaction with ATG7 and nuclear transactivation of ATG7 expressionPrognostic value of peritumoral heat-shock factor-1 in patients receiving resection of hepatocellular carcinoma.HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth.Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state.Multifaceted roles of HSF1 in cancer.Metabolic control of the proteotoxic stress response: implications in diabetes mellitus and neurodegenerative disorders.Glucose regulates heat shock factor 1 transcription activity via mTOR pathway in HCC cell lines.Fisetin, a dietary flavonoid, induces apoptosis of cancer cells by inhibiting HSF1 activity through blocking its binding to the hsp70 promoter.Metabolic stressors disrupt proteome homeostasis to suppress malignancyThe transcriptional regulator of the chaperone response HSF1 controls hepatic bioenergetics and protein homeostasis.Nucleoside analog inhibits microRNA-214 through targeting heat-shock factor 1 in human epithelial ovarian cancer.Targeting HSF1 sensitizes cancer cells to HSP90 inhibition.HSF1, a versatile factor in tumorogenesis.Inhibition of HSF1 suppresses the growth of hepatocarcinoma cell lines in vitro and AKT-driven hepatocarcinogenesis in mice.Cellular stress response cross talk maintains protein and energy homeostasis.Inactivation of heat shock factor Hsf4 induces cellular senescence and suppresses tumorigenesis in vivo.Loss of AMPK activation promotes the invasion and metastasis of pancreatic cancer through an HSF1-dependent pathway
P2860
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P2860
Heat shock transcription factor 1 is a key determinant of HCC development by regulating hepatic steatosis and metabolic syndrome.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Heat shock transcription facto ...... atosis and metabolic syndrome.
@ast
Heat shock transcription facto ...... atosis and metabolic syndrome.
@en
type
label
Heat shock transcription facto ...... atosis and metabolic syndrome.
@ast
Heat shock transcription facto ...... atosis and metabolic syndrome.
@en
prefLabel
Heat shock transcription facto ...... atosis and metabolic syndrome.
@ast
Heat shock transcription facto ...... atosis and metabolic syndrome.
@en
P2093
P2860
P1433
P1476
Heat shock transcription facto ...... atosis and metabolic syndrome.
@en
P2093
Demetrius Moskophidis
Nahid F Mivechi
Xiongjie Jin
P2860
P304
P356
10.1016/J.CMET.2011.03.025
P577
2011-07-01T00:00:00Z