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The Octadecyloxyethyl Ester of (S)-9-[3-Hydroxy-2-(Phosphonomethoxy) Propyl]Adenine Is a Potent and Selective Inhibitor of Hepatitis C Virus Replication in Genotype 1A, 1B, and 2A RepliconsDiscovery of an acyclic nucleoside phosphonate that inhibits Mycobacterium tuberculosis ThyX based on the binding mode of a 5-alkynyl substrate analogue.Synthesis of a new family of acyclic nucleoside phosphonates, analogues of TPases transition states.Acyclic nucleoside phosphonates: a key class of antiviral drugs.Approaches to tyrosine-linked peptidomimetic prodrugs of (S)-HPMP-based acyclic nucleoside phosphonates.Alkoxyalkyl esters of (S)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine are potent inhibitors of the replication of wild-type and drug-resistant human immunodeficiency virus type 1 in vitro.Tyrosine-based 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine and -adenine ((S)-HPMPC and (S)-HPMPA) prodrugs: synthesis, stability, antiviral activity, and in vivo transport studiesAntiviral activities of novel 5-phosphono-pent-2-en-1-yl nucleosides and their alkoxyalkyl phosphonoestersEvaluation of hexadecyloxypropyl-9-R-[2-(Phosphonomethoxy)propyl]- adenine, CMX157, as a potential treatment for human immunodeficiency virus type 1 and hepatitis B virus infections.Adenine: an important drug scaffold for the design of antiviral agentsDesign and profiling of GS-9148, a novel nucleotide analog active against nucleoside-resistant variants of human immunodeficiency virus type 1, and its orally bioavailable phosphonoamidate prodrug, GS-9131.Serine peptide phosphoester prodrugs of cyclic cidofovir: synthesis, transport, and antiviral activityEvolution of an amino acid based prodrug approach: stay tuned.Alkoxyalkyl esters of 9-(s)-(3-hydroxy-2-phosphonomethoxypropyl) adenine are potent and selective inhibitors of hepatitis B virus (HBV) replication in vitro and in HBV transgenic mice in vivoAntiviral evaluation of octadecyloxyethyl esters of (S)-3-hydroxy-2-(phosphonomethoxy)propyl nucleosides against herpesviruses and orthopoxviruses.5-azacytosine compounds in medicinal chemistry: current stage and future perspectives.The acyclic nucleoside phosphonates (ANPs): Antonín Holý's legacy.Comparison of the π-stacking properties of purine versus pyrimidine residues. Some generalizations regarding selectivity.8-Azapurines as isosteric purine fluorescent probes for nucleic acid and enzymatic research.KSHV targeted therapy: an update on inhibitors of viral lytic replication.1-Amino-3-(1H-1,2,3-triazol-1-yl)propylphosphonates as acyclic analogs of nucleotides.Novel acyclic phosphonylated 1,2,3-triazolonucleosides with an acetamidomethyl linker: synthesis and biological activity.Amidate prodrugs of 9-[2-(phosphonomethoxy)ethyl]adenine as inhibitors of adenylate cyclase toxin from Bordetella pertussis.Synthesis and biological evaluation of novel 1,2,3-triazolonucleotides.Synthesis of 3'-o-phosphonoethyl nucleosides with an adenine and a thymine base moiety.Acyclic nucleoside bisphosphonates: synthesis and properties of chiral 2-amino-4,6-bis[(phosphonomethoxy)alkoxy]pyrimidinesSyntheses of pyrimidine acyclic nucleoside phosphonates as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma.Synthesis of acyclic nucleoside phosphonates.Synthesis and antiviral evaluation of alkoxyalkyl-phosphate conjugates of cidofovir and adefovir.Activities of acyclic nucleoside phosphonates against Orf virus in human and ovine cell monolayers and organotypic ovine raft culturesNovel acyclic nucleoside phosphonate analogues with potent anti-hepatitis B virus activities.Phosphonylated Acyclic Guanosine Analogues with the 1,2,3-Triazole Linker.Synthesis and Anti-HIV Activity of Novel 4'-Trifluoromethylated 5'-Deoxycarbocyclic Nucleoside Phosphonic Acids.Synthesis of peptidomimetic conjugates of cyclic nucleoside phosphonates.Synthesis of cidofovir and (S)-HPMPA ether lipid prodrugs.Synthesis and antiviral evaluation of novel 4'-trifluoromethylated 5'-deoxyapiosyl nucleoside phosphonic acids.Synthesis of novel 2'-fluoro-3'-hydroxymethyl-5'-deoxythreosyl phosphonic acid nucleoside analogues as antiviral agents.Synthesis and biological activation of an ethylene glycol-linked amino acid conjugate of cyclic cidofovirDiethyl (6-amino-9H-purin-9-yl) methylphosphonate induces apoptosis and cell cycle arrest in hepatocellular carcinoma BEL-7402 cells: Role of reactive oxygen species.Transdermal delivery and cutaneous targeting of antivirals using a penetration enhancer and lysolipid prodrugs.
P2860
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P2860
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Phosphonomethoxyalkyl analogs of nucleotides.
@ast
Phosphonomethoxyalkyl analogs of nucleotides.
@en
type
label
Phosphonomethoxyalkyl analogs of nucleotides.
@ast
Phosphonomethoxyalkyl analogs of nucleotides.
@en
prefLabel
Phosphonomethoxyalkyl analogs of nucleotides.
@ast
Phosphonomethoxyalkyl analogs of nucleotides.
@en
P356
P1476
Phosphonomethoxyalkyl analogs of nucleotides.
@en
P2093
Antonín Holy
P304
P356
10.2174/1381612033453668
P50
P577
2003-01-01T00:00:00Z