Role of the low density lipoprotein receptor in the flux of cholesterol through the plasma and across the tissues of the mouse.
about
Functional dissection of an AP-2 beta2 appendage-binding sequence within the autosomal recessive hypercholesterolemia proteinDifferential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cellsAdenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotypeCholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brainCytochrome P450s in the synthesis of cholesterol and bile acids--from mouse models to human diseases.Normal sorting but defective endocytosis of the low density lipoprotein receptor in mice with autosomal recessive hypercholesterolemiaHigh susceptibility to fatty liver disease in two-pore channel 2-deficient miceHepatobiliary cholesterol transport is not impaired in Abca1-null mice lacking HDLParameter trajectory analysis to identify treatment effects of pharmacological interventionsElevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 geneDisturbed cholesterol homeostasis in a peroxisome-deficient PEX2 knockout mouse modelElevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4Effect of up-regulating individual steps in the reverse cholesterol transport pathway on reverse cholesterol transport in normolipidemic miceFlux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathwaysCCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDLThe Niemann-Pick C1 and caveolin-1 proteins interact to modulate efflux of low density lipoprotein-derived cholesterol from late endocytic compartments.Localized delivery of low-density lipoprotein docosahexaenoic acid nanoparticles to the rat brain using focused ultrasoundMouse models to study the effect of cardiovascular risk factors on brain structure and cognitionA single common portal for clathrin-mediated endocytosis of distinct cargo governed by cargo-selective adaptors.Physiological and therapeutic regulation of PCSK9 activity in cardiovascular disease.Apolipoprotein E competitively inhibits receptor-dependent low density lipoprotein uptake by the liver but has no effect on cholesterol absorption or synthesis in the mouse.Cyclodextrin overcomes the transport defect in nearly every organ of NPC1 mice leading to excretion of sequestered cholesterol as bile acidNiemann-Pick C disease and mobilization of lysosomal cholesterol by cyclodextrinParameter adaptations during phenotype transitions in progressive diseases.Chylomicron- and VLDL-derived lipids enter the heart through different pathways: in vivo evidence for receptor- and non-receptor-mediated fatty acid uptake.Hepatic entrapment of esterified cholesterol drives continual expansion of whole body sterol pool in lysosomal acid lipase-deficient miceMultiple mechanisms limit the accumulation of unesterified cholesterol in the small intestine of mice deficient in both ACAT2 and ABCA1.Control of cholesterol turnover in the mouse.Absence of an effect of vitamin E on protein and lipid radical formation during lipoperoxidation of LDL by lipoxygenase.A Mechanistic Systems Pharmacology Model for Prediction of LDL Cholesterol Lowering by PCSK9 Antagonism in Human Dyslipidemic PopulationsReduction of the cholesterol sensor SCAP in the brains of mice causes impaired synaptic transmission and altered cognitive function.Reverse cholesterol transport is elevated in carboxyl ester lipase-knockout miceCentral nervous system: cholesterol turnover, brain development and neurodegeneration.GM2/GD2 and GM3 gangliosides have no effect on cellular cholesterol pools or turnover in normal or NPC1 mice.The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression.Cholesterol accumulation in tissues of the Niemann-pick type C mouse is determined by the rate of lipoprotein-cholesterol uptake through the coated-pit pathway in each organ.The effects of jiang-zhi-ning and its main components on cholesterol metabolism.PRD125, a potent and selective inhibitor of sterol O-acyltransferase 2 markedly reduces hepatic cholesteryl ester accumulation and improves liver function in lysosomal acid lipase-deficient miceHigh density lipoprotein metabolism in low density lipoprotein receptor-deficient mice.A Genome-Wide Association Study Identifies the Genomic Region Associated with Shell Color in Yesso Scallop, Patinopecten yessoensis.
P2860
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P2860
Role of the low density lipoprotein receptor in the flux of cholesterol through the plasma and across the tissues of the mouse.
description
1995 nî lūn-bûn
@nan
1995 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի մարտին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Role of the low density lipopr ...... ross the tissues of the mouse.
@ast
Role of the low density lipopr ...... ross the tissues of the mouse.
@en
type
label
Role of the low density lipopr ...... ross the tissues of the mouse.
@ast
Role of the low density lipopr ...... ross the tissues of the mouse.
@en
prefLabel
Role of the low density lipopr ...... ross the tissues of the mouse.
@ast
Role of the low density lipopr ...... ross the tissues of the mouse.
@en
P2093
P2860
P356
P1476
Role of the low density lipopr ...... ross the tissues of the mouse.
@en
P2093
P2860
P304
P356
10.1172/JCI117760
P407
P577
1995-03-01T00:00:00Z