Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes
about
Role of ND10 nuclear bodies in the chromatin repression of HSV-1KDM1 class flavin-dependent protein lysine demethylasesLSD1 Histone Demethylase Assays and InhibitionRestarting Lytic Gene Transcription at the Onset of Herpes Simplex Virus ReactivationNeuronal Stress Pathway Mediating a Histone Methyl/Phospho Switch Is Required for Herpes Simplex Virus Reactivation.Dynamic modulation of HSV chromatin drives initiation of infection and provides targets for epigenetic therapies.Nuclear sensing of viral DNA, epigenetic regulation of herpes simplex virus infection, and innate immunityLimits and patterns of cytomegalovirus genomic diversity in humans.An Essential Viral Transcription Activator Modulates Chromatin DynamicsClues to mechanisms of herpesviral latent infection and potential curesEpigenetically repressing human cytomegalovirus lytic infection and reactivation from latency in THP-1 model by targeting H3K9 and H3K27 histone demethylases.Herpesviral ICP0 Protein Promotes Two Waves of Heterochromatin Removal on an Early Viral Promoter during Lytic Infection.Anaplasma phagocytophilum increases the levels of histone modifying enzymes to inhibit cell apoptosis and facilitate pathogen infection in the tick vector Ixodes scapularis.A Herpesviral Lytic Protein Regulates the Structure of Latent Viral Chromatin.Inhibitors of the Histone Methyltransferases EZH2/1 Induce a Potent Antiviral State and Suppress Infection by Diverse Viral Pathogens.Profiling of Host Cell Response to Successive Canine Parvovirus Infection Based on Kinetic Proteomic Change Identification.Transcriptional Elongation of HSV Immediate Early Genes by the Super Elongation Complex Drives Lytic Infection and Reactivation from Latency.Epigenetics and Genetics of Viral Latency.Viral gene products actively promote latent infection by epigenetic silencing mechanisms.The enzymes LSD1 and Set1A cooperate with the viral protein HBx to establish an active hepatitis B viral chromatin state.Inhibition of H3K27me3-specific histone demethylases JMJD3 and UTX blocks reactivation of herpes simplex virus 1 in trigeminal ganglion neurons.Histone demethylase LSD1 restricts influenza A virus infection by erasing IFITM3-K88 monomethylation.The loss of binary: Pushing the herpesvirus latency paradigm.Towards the development of activity-based probes for detection of lysine-specific demethylase-1 activity.Effect of a Histone Demethylase Inhibitor on Equine Herpesvirus-1 Activity In Vitro.Clinical management of herpes simplex virus infections: past, present, and future
P2860
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P2860
Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
Inhibition of LSD1 reduces her ...... c suppression of viral genomes
@ast
Inhibition of LSD1 reduces her ...... c suppression of viral genomes
@en
type
label
Inhibition of LSD1 reduces her ...... c suppression of viral genomes
@ast
Inhibition of LSD1 reduces her ...... c suppression of viral genomes
@en
prefLabel
Inhibition of LSD1 reduces her ...... c suppression of viral genomes
@ast
Inhibition of LSD1 reduces her ...... c suppression of viral genomes
@en
P2093
P2860
P1476
Inhibition of LSD1 reduces her ...... c suppression of viral genomes
@en
P2093
Christian Clement
David I Bernstein
David M Knipe
Debra C Quenelle
Fernando J Bravo
James M Hill
Jodi L Vogel
Marta Bosch-Marce
Priya Raja
Rhonda D Cardin
P2860
P304
P356
10.1126/SCITRANSLMED.3010643
P407
P577
2014-12-01T00:00:00Z