Islet cholesterol accumulation due to loss of ABCA1 leads to impaired exocytosis of insulin granules. - Wikidata - wikimedia - TriplyDB

Islet cholesterol accumulation due to loss of ABCA1 leads to impaired exocytosis of insulin granules.

Islet cholesterol accumulation due to loss of ABCA1 leads to impaired exocytosis of insulin granules.

http://www.wikidata.org/entity/Q35561092

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The role of cholesterol in membrane fusion β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.Combined lipidomic and proteomic analysis of isolated human islets exposed to palmitate reveals time-dependent changes in insulin secretion and lipid metabolism Increased risk for diabetes development in subjects with large variation in total cholesterol levels in 2,827,950 Koreans: A nationwide population-based study Exposure to high levels of glucose increases the expression levels of genes involved in cholesterol biosynthesis in rat islets Skeletal muscle insulin resistance associated with cholesterol-induced activation of macrophages is prevented by high density lipoprotein.Characterization of phospholipids in insulin secretory granules and mitochondria in pancreatic beta cells and their changes with glucose stimulation.miR-33a modulates ABCA1 expression, cholesterol accumulation, and insulin secretion in pancreatic islets.Effect of Serum Cholesterol on Insulin Secretory Capacity: Shimane CoHRE Study.Pancreatic β-Cell Dysfunction in Diet-Induced Obese Mice: Roles of AMP-Kinase, Protein Kinase Cε, Mitochondrial and Cholesterol Metabolism, and Alterations in Gene Expression Dietary fat and carbohydrate modulate the effect of the ATP-binding cassette A1 (ABCA1) R230C variant on metabolic risk parameters in premenopausal women from the Genetics of Atherosclerotic Disease (GEA) Study Restoring Mitochondrial Function: A Small Molecule-mediated Approach to Enhance Glucose Stimulated Insulin Secretion in Cholesterol Accumulated Pancreatic beta cells Cholesterol-enriched membrane rafts and insulin secretion.High-density lipoprotein, beta cells, and diabetes .Advances in high-density lipoprotein physiology: surprises, overturns, and promises.ABCA1 deficiency and cellular cholesterol accumulation increases islet amyloidogenesis in mice.Loss of both ABCA1 and ABCG1 results in increased disturbances in islet sterol homeostasis, inflammation, and impaired β-cell function.Cholesterol accumulation in podocytes: a potential novel targetable pathway in diabetic nephropathy.Balsamic Vinegar Improves High Fat-Induced Beta Cell Dysfunction via Beta Cell ABCA1.Killing two birds with one stone, maybe: CETP inhibition increases both high-density lipoprotein levels and insulin secretion.Impact of Perturbed Pancreatic β-Cell Cholesterol Homeostasis on Adipose Tissue and Skeletal Muscle Metabolism.Ranking factors involved in diabetes remission after bariatric surgery using machine-learning integrating clinical and genomic biomarkers.The Association between Persistent Hypertriglyceridemia and the Risk of Diabetes Development: The Kangbuk Samsung Health Study.Hepatocyte ABCA1 Deletion Impairs Liver Insulin Signaling and Lipogenesis.Variable effects of gender and Western diet on lipid and glucose homeostasis in aged PCSK9-deficient C57BL/6 mice CSK9PC57BL/6.Control of Insulin Granule Formation and Function by the ABC Transporters ABCG1 and ABCA1 and by Oxysterol Binding Protein OSBP.Unexplained reciprocal regulation of diabetes and lipoproteins.Modulation of Amyloidogenesis Controlled by the C-Terminal Domain of Islet Amyloid Polypeptide Shows New Functions on Hepatocyte Cholesterol Metabolism.Reinterpretation of the localization of the ATP binding cassette transporter ABCG1 in insulin-secreting cells and insights regarding its trafficking and function

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P2860

Islet cholesterol accumulation due to loss of ABCA1 leads to impaired exocytosis of insulin granules.

http://www.wikidata.org/entity/Q35561092

description

2011 nî lūn-bûn

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

@zh-tw

2011年论文

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2011年论文

@zh

2011年论文

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name

Islet cholesterol accumulation ...... xocytosis of insulin granules.

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Islet cholesterol accumulation ...... xocytosis of insulin granules.

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type

label

Islet cholesterol accumulation ...... xocytosis of insulin granules.

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Islet cholesterol accumulation ...... xocytosis of insulin granules.

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prefLabel

Islet cholesterol accumulation ...... xocytosis of insulin granules.

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Islet cholesterol accumulation ...... xocytosis of insulin granules.

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Brad J Marsh

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C Bruce Verchere

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Garry P Morgan

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Gavin J Searle

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Janine K Kruit

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Liam R Brunham

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Nadeeja Wijesekara

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P2860

SUMOylation regulates Kv2.1 and modulates pancreatic beta-cell excitability

Increased islet apoptosis in Pdx1+/- mice

A subset of 50 secretory granules in close contact with L-type Ca2+ channels accounts for first-phase insulin secretion in mouse beta-cells.

Fast exocytosis with few Ca(2+) channels in insulin-secreting mouse pancreatic B cells

Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment

Insulin granule recruitment and exocytosis is dependent on p110gamma in insulinoma and human beta-cells

ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins

An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic beta cells.

Clustering of syntaxin-1A in model membranes is modulated by phosphatidylinositol 4,5-bisphosphate and cholesterol.

t-SNARE protein conformations patterned by the lipid microenvironment.

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