Demonstration that drug-targeted down-regulation of MYC in non-Hodgkins lymphoma is directly mediated through the promoter G-quadruplex.
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Getting Ready for the Dance: FANCJ Irons Out DNA WrinklesStructure of Nucleophosmin DNA-binding Domain and Analysis of Its Complex with a G-quadruplex Sequence from the c-MYC PromoterMYC on the path to cancerU3 region in the HIV-1 genome adopts a G-quadruplex structure in its RNA and DNA sequence.Bisquinolinium compounds induce quadruplex-specific transcriptome changes in HeLa S3 cell lines.Gaining insights into the small molecule targeting of the G-quadruplex in the c-MYC promoter using NMR and an allele-specific transcriptional assay.The guanine-quadruplex structure in the human c-myc gene's promoter is converted into B-DNA form by the human poly(ADP-ribose)polymerase-1.Molecular and cellular functions of the FANCJ DNA helicase defective in cancer and in Fanconi anemiaMolecular classification, pathway addiction, and therapeutic targeting in diffuse large B cell lymphomaSmall Molecule Microarrays Enable the Identification of a Selective, Quadruplex-Binding Inhibitor of MYC Expression.Anticancer activity and cellular repression of c-MYC by the G-quadruplex-stabilizing 11-piperazinylquindoline is not dependent on direct targeting of the G-quadruplex in the c-MYC promoterStrategies to Inhibit Myc and Their Clinical ApplicabilityOld drug, new target: ellipticines selectively inhibit RNA polymerase I transcription.Targeting MYC in cancer therapy: RNA processing offers new opportunities.DNA secondary structures: stability and function of G-quadruplex structures.Nucleic acid clamp-mediated recognition and stabilization of the physiologically relevant MYC promoter G-quadruplex.G-quadruplexes: targets and tools in anticancer drug design.Nucleophosmin mutations in acute myeloid leukemia: a tale of protein unfolding and mislocalization.Targeting non-B-form DNA in living cells.G-quadruplex structures in the human genome as novel therapeutic targets.Targeting RNA polymerase I to treat MYC-driven cancer.In silico identification of novel ligands for G-quadruplex in the c-MYC promoter.Demonstration of a potent RET transcriptional inhibitor for the treatment of medullary thyroid carcinoma based on an ellipticine derivative.The Consequences of Overlapping G-Quadruplexes and i-Motifs in the Platelet-Derived Growth Factor Receptor β Core Promoter Nuclease Hypersensitive Element Can Explain the Unexpected Effects of Mutations and Provide Opportunities for Selective TargetTarget guided synthesis using DNA nano-templates for selectively assembling a G-quadruplex binding c-MYC inhibitor.Not all G-quadruplexes are created equally: an investigation of the structural polymorphism of the c-Myc G-quadruplex-forming sequence and its interaction with the porphyrin TMPyP4Identification of G-Quadruplex Inducers Usinga Simple, Inexpensiveand Rapid High Throughput Assay, and TheirInhibition of Human TelomeraseSmall molecule selectively suppresses MYC transcription in cancer cells.c-Myc and cancer metabolism.DNA structure: Visualizing the quadruplex.Specific G-quadruplex ligands modulate the alternative splicing of Bcl-X.Diffuse large B-cell lymphoma cell-of-origin classification using the Lymph2Cx assay in the context of BCL2 and MYC expression status.Targeting multiple effector pathways in pancreatic ductal adenocarcinoma with a G-quadruplex-binding small molecule.Design, Synthesis and Biological Evaluation of New Substituted Diquinolinyl-Pyridine Ligands as Anticancer Agents by Targeting G-Quadruplex.Targeting promoter G-quadruplex DNAs by indenopyrimidine-based ligands.Small-Molecule Targeting of RNA Polymerase I Activates a Conserved Transcription Elongation Checkpoint.Benzothiazole hydrazones of furylbenzamides preferentially stabilize c-MYC and c-KIT1 promoter G-quadruplex DNAs.Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplexOxadiazole/Pyridine-Based Ligands: A Structural Tuning for Enhancing G-Quadruplex Bindingi-Motif DNA: structural features and significance to cell biology
P2860
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P2860
Demonstration that drug-targeted down-regulation of MYC in non-Hodgkins lymphoma is directly mediated through the promoter G-quadruplex.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Demonstration that drug-target ...... ugh the promoter G-quadruplex.
@ast
Demonstration that drug-target ...... ugh the promoter G-quadruplex.
@en
type
label
Demonstration that drug-target ...... ugh the promoter G-quadruplex.
@ast
Demonstration that drug-target ...... ugh the promoter G-quadruplex.
@en
prefLabel
Demonstration that drug-target ...... ugh the promoter G-quadruplex.
@ast
Demonstration that drug-target ...... ugh the promoter G-quadruplex.
@en
P2093
P2860
P356
P1476
Demonstration that drug-target ...... ugh the promoter G-quadruplex.
@en
P2093
Forest L Danford
Laurence H Hurley
Robert V Brown
Tracy A Brooks
Vijay Gokhale
P2860
P304
41018-41027
P356
10.1074/JBC.M111.274720
P407
P577
2011-09-28T00:00:00Z