Anticancer activity and cellular repression of c-MYC by the G-quadruplex-stabilizing 11-piperazinylquindoline is not dependent on direct targeting of the G-quadruplex in the c-MYC promoter
about
Non-B DB v2.0: a database of predicted non-B DNA-forming motifs and its associated toolsTargeting a c-MYC G-quadruplex DNA with a fragment library.Indolo[3,2-c]quinoline G-quadruplex stabilizers: a structural analysis of binding to the human telomeric G-quadruplex.Small Molecule Microarrays Enable the Identification of a Selective, Quadruplex-Binding Inhibitor of MYC Expression.Screening of candidate G-quadruplex ligands for the human c-KIT promotorial region and their effects in multiple in-vitro models.DNA secondary structures: stability and function of G-quadruplex structures.MYC functions are specific in biological subtypes of breast cancer and confers resistance to endocrine therapy in luminal tumours.Nucleic acid clamp-mediated recognition and stabilization of the physiologically relevant MYC promoter G-quadruplex.G-quadruplex interacting small molecules and drugs: from bench toward bedside.Conformation-sensitive nucleoside analogues as topology-specific fluorescence turn-on probes for DNA and RNA G-quadruplexes.A targeted oligonucleotide enhancer of SMN2 exon 7 splicing forms competing quadruplex and protein complexes in functional conditions.A Nucleus-Imaging Probe That Selectively Stabilizes a Minor Conformation of c-MYC G-quadruplex and Down-regulates c-MYC Transcription in Human Cancer CellsSynthesis, G-quadruplex stabilisation, docking studies, and effect on cancer cells of indolo[3,2-b]quinolines with one, two, or three basic side chains.Target guided synthesis using DNA nano-templates for selectively assembling a G-quadruplex binding c-MYC inhibitor.Flexibility and structural conservation in a c-KIT G-quadruplex.A platinum(II) phenylphenanthroimidazole with an extended side-chain exhibits slow dissociation from a c-Kit G-quadruplex motif.Specific G-quadruplex ligands modulate the alternative splicing of Bcl-X.Targeting multiple effector pathways in pancreatic ductal adenocarcinoma with a G-quadruplex-binding small molecule.Targeting promoter G-quadruplex DNAs by indenopyrimidine-based ligands.Benzothiazole hydrazones of furylbenzamides preferentially stabilize c-MYC and c-KIT1 promoter G-quadruplex DNAs.Microwave-assisted synthesis of arene ruthenium(II) complexes [(η⁶-RC₆H₅)Ru(m-MOPIP)Cl]Cl (R = -H and -CH₃) as groove binder to c-myc G4 DNA.Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplexFluorescent Dansyl-Guanosine Conjugates that Bindc-MYCPromoter G-Quadruplex and Downregulatec-MYCExpressionSite-specific amino acid substitution in dodecameric peptides determines the stability and unfolding of c-MYC quadruplex promoting apoptosis in cancer cells
P2860
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P2860
Anticancer activity and cellular repression of c-MYC by the G-quadruplex-stabilizing 11-piperazinylquindoline is not dependent on direct targeting of the G-quadruplex in the c-MYC promoter
description
2012 nî lūn-bûn
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2012年の論文
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2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
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2012年论文
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2012年论文
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name
Anticancer activity and cellul ...... adruplex in the c-MYC promoter
@ast
Anticancer activity and cellul ...... adruplex in the c-MYC promoter
@en
type
label
Anticancer activity and cellul ...... adruplex in the c-MYC promoter
@ast
Anticancer activity and cellul ...... adruplex in the c-MYC promoter
@en
prefLabel
Anticancer activity and cellul ...... adruplex in the c-MYC promoter
@ast
Anticancer activity and cellul ...... adruplex in the c-MYC promoter
@en
P2093
P2860
P356
P1476
Anticancer activity and cellul ...... adruplex in the c-MYC promoter
@en
P2093
Biswanath De
Cristina Beman
Laurence H Hurley
Peda V L Boddupally
Seongmin Hahn
Tracy A Brooks
Vijay Gokhale
P2860
P304
P356
10.1021/JM300282C
P407
P577
2012-06-25T00:00:00Z