Mechanism of HIV reverse transcriptase inhibition by zinc: formation of a highly stable enzyme-(primer-template) complex with profoundly diminished catalytic activity.
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Inhibition of aminoglycoside 6'-N-acetyltransferase type Ib by zinc: reversal of amikacin resistance in Acinetobacter baumannii and Escherichia coli by a zinc ionophoreHuman immunodeficiency virus reverse transcriptase displays dramatically higher fidelity under physiological magnesium conditions in vitro.A MIV-150/zinc acetate gel inhibits SHIV-RT infection in macaque vaginal explantsAlternative divalent cations (Zn²⁺, Co²⁺, and Mn²⁺) are not mutagenic at conditions optimal for HIV-1 reverse transcriptase activity.A single dose of a MIV-150/Zinc acetate gel provides 24 h of protection against vaginal simian human immunodeficiency virus reverse transcriptase infection, with more limited protection rectally 8-24 h after gel use.Metal and ligand binding to the HIV-RNase H active site are remotely monitored by Ile556A modified zinc acetate gel, a potential nonantiretroviral microbicide, is safe and effective against simian-human immunodeficiency virus and herpes simplex virus 2 infection in vivo.First-in-Human Trial of MIV-150 and Zinc Acetate Coformulated in a Carrageenan Gel: Safety, Pharmacokinetics, Acceptability, Adherence, and Pharmacodynamics.MIV-150 and zinc acetate combination provides potent and broad activity against HIV-1.An intravaginal ring that releases three antiviral agents and a contraceptive blocks SHIV-RT infection, reduces HSV-2 shedding, and suppresses hormonal cycling in rhesus macaques.Preferential Ty1 retromobility in mother cells and nonquiescent stationary phase cells is associated with increased concentrations of total Gag or processed Gag and is inhibited by exposure to a high concentration of calcium.
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P2860
Mechanism of HIV reverse transcriptase inhibition by zinc: formation of a highly stable enzyme-(primer-template) complex with profoundly diminished catalytic activity.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
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2011年论文
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2011年论文
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name
Mechanism of HIV reverse trans ...... diminished catalytic activity.
@ast
Mechanism of HIV reverse trans ...... diminished catalytic activity.
@en
type
label
Mechanism of HIV reverse trans ...... diminished catalytic activity.
@ast
Mechanism of HIV reverse trans ...... diminished catalytic activity.
@en
prefLabel
Mechanism of HIV reverse trans ...... diminished catalytic activity.
@ast
Mechanism of HIV reverse trans ...... diminished catalytic activity.
@en
P2860
P356
P1476
Mechanism of HIV reverse trans ...... diminished catalytic activity
@en
P2093
Jeffrey J DeStefano
P2860
P304
40433-40442
P356
10.1074/JBC.M111.289850
P407
P577
2011-09-26T00:00:00Z