Functional characterization of RNA-dependent DNA polymerase and RNase H activities of a recombinant HIV reverse transcriptase
about
Stable complexes formed by HIV-1 reverse transcriptase at distinct positions on the primer-template controlled by binding deoxynucleoside triphosphates or foscarnetMg2+ dependency of HIV-1 reverse transcription, inhibition by nucleoside analogues and resistance.Nonnucleoside reverse transcriptase inhibitors that potently and specifically block human immunodeficiency virus type 1 replicationUnblocking of chain-terminated primer by HIV-1 reverse transcriptase through a nucleotide-dependent mechanismInteractions between HIV-1 reverse transcriptase and the downstream template strand in stable complexes with primer-templateSubstitution of a highly basic helix/loop sequence into the RNase H domain of human immunodeficiency virus reverse transcriptase restores its Mn(2+)-dependent RNase H activity.Relationship between 3'-azido-3'-deoxythymidine resistance and primer unblocking activity in foscarnet-resistant mutants of human immunodeficiency virus type 1 reverse transcriptase.HIV-1 reverse transcriptase dissociates during strand transfer.Mechanism of HIV reverse transcriptase inhibition by zinc: formation of a highly stable enzyme-(primer-template) complex with profoundly diminished catalytic activity.Utilization of a deoxynucleoside diphosphate substrate by HIV reverse transcriptase.Purification and characterization of an active human immunodeficiency virus type 1 RNase H domain.Mechanisms of the inhibition of reverse transcription by antisense oligonucleotides.Chain-terminating dinucleoside tetraphosphates are substrates for DNA polymerization by human immunodeficiency virus type 1 reverse transcriptase with increased activity against thymidine analogue-resistant mutants.Effects of dipeptide insertions between codons 69 and 70 of human immunodeficiency virus type 1 reverse transcriptase on primer unblocking, deoxynucleoside triphosphate inhibition, and DNA chain elongation.Constitutive production of nonenveloped human immunodeficiency virus type 1 particles by a mammalian cell line and effects of a protease inhibitor on particle maturation.Quantitative analysis of RNA cleavage during RNA-directed DNA synthesis by human immunodeficiency and avian myeloblastosis virus reverse transcriptases.Inhibitory effects of quinones on RNase H activity associated with HIV-1 reverse transcriptase.Effects of primer-template sequence on ATP-dependent removal of chain-terminating nucleotide analogues by HIV-1 reverse transcriptase.Preferential Ty1 retromobility in mother cells and nonquiescent stationary phase cells is associated with increased concentrations of total Gag or processed Gag and is inhibited by exposure to a high concentration of calcium.
P2860
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P2860
Functional characterization of RNA-dependent DNA polymerase and RNase H activities of a recombinant HIV reverse transcriptase
description
1991 nî lūn-bûn
@nan
1991 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի մարտին հրատարակված գիտական հոդված
@hy
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
name
Functional characterization of ...... nant HIV reverse transcriptase
@ast
Functional characterization of ...... nant HIV reverse transcriptase
@en
Functional characterization of ...... nant HIV reverse transcriptase
@nl
type
label
Functional characterization of ...... nant HIV reverse transcriptase
@ast
Functional characterization of ...... nant HIV reverse transcriptase
@en
Functional characterization of ...... nant HIV reverse transcriptase
@nl
prefLabel
Functional characterization of ...... nant HIV reverse transcriptase
@ast
Functional characterization of ...... nant HIV reverse transcriptase
@en
Functional characterization of ...... nant HIV reverse transcriptase
@nl
P2093
P356
P1433
P1476
Functional characterization of ...... nant HIV reverse transcriptase
@en
P2093
P304
P356
10.1021/BI00224A013
P407
P577
1991-03-12T00:00:00Z