Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons.
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The RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signalingLithium: the pharmacodynamic actions of the amazing ionRegulation of glycogen synthase kinase-3 during bipolar mania treatmentTherapeutic potential of mood stabilizers lithium and valproic acid: beyond bipolar disorderGlycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeuticsA new look at an old drug: neuroprotective effects and therapeutic potentials of lithium saltsThe Role of the PI3K Pathway in the Regeneration of the Damaged Brain by Neural Stem Cells after Cerebral InfarctionAntidepressant mechanism of ketamine: perspective from preclinical studiesReview of pharmacological treatment in mood disorders and future directions for drug development.Lithium and autophagyDysregulation of the norepinephrine transporter sustains cortical hypodopaminergia and schizophrenia-like behaviors in neuronal rictor null miceCellular plasticity cascades in the pathophysiology and treatment of bipolar disorderMolecular actions and clinical pharmacogenetics of lithium therapySynergistic neuroprotective effects of lithium and valproic acid or other histone deacetylase inhibitors in neurons: roles of glycogen synthase kinase-3 inhibitionLithium therapy improves neurological function and hippocampal dendritic arborization in a spinocerebellar ataxia type 1 mouse model.Involvement of the glycogen synthase kinase-3 signaling pathway in TBI pathology and neurocognitive outcomeAltered regulation of Akt signaling with murine cerebral malaria, effects on long-term neuro-cognitive function, restoration with lithium treatmentAbnormal development of NG2+PDGFR-α+ neural progenitor cells leads to neonatal hydrocephalus in a ciliopathy mouse modelGlutamate acting on N-methyl-D-aspartate receptors attenuates insulin-like growth factor-1 receptor tyrosine phosphorylation and its survival signaling properties in rat hippocampal neuronsFGF-21, a novel metabolic regulator, has a robust neuroprotective role and is markedly elevated in neurons by mood stabilizersNFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapyDiacylglycerol kinase β knockout mice exhibit lithium-sensitive behavioral abnormalities.Influence of single and binary doping of strontium and lithium on in vivo biological properties of bioactive glass scaffoldsProtective Effect of Minocycline Against Ketamine-Induced Injury in Neural Stem Cell: Involvement of PI3K/Akt and Gsk-3 Beta Pathway.Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithiumDeletion of GSK3β in D2R-expressing neurons reveals distinct roles for β-arrestin signaling in antipsychotic and lithium action.Activation of GABA(B) receptors inhibits protein kinase B/glycogen synthase kinase 3 signaling.Is glycogen synthase kinase-3 a central modulator in mood regulation?Selective deletion of forebrain glycogen synthase kinase 3β reveals a central role in serotonin-sensitive anxiety and social behaviourIntegrin signaling via the PI3-kinase-Akt pathway increases neuronal resistance to glutamate-induced apoptosis.A systematic review of existing data on long-term lithium therapy: neuroprotective or neurotoxic?Beneficial effects of mood stabilizers lithium, valproate and lamotrigine in experimental stroke models.The neurotrophic and neuroprotective effects of psychotropic agents.Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease.Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivoNeuroprotective effects of lithium: implications for the treatment of Alzheimer's disease and related neurodegenerative disordersA new avenue for lithium: intervention in traumatic brain injury.Telmisartan protects central neurons against nutrient deprivation-induced apoptosis in vitro through activation of PPARγ and the Akt/GSK-3β pathway.Lithium suppresses astrogliogenesis by neural stem and progenitor cells by inhibiting STAT3 pathway independently of glycogen synthase kinase 3 beta.Protocol for a double-blind randomised placebo-controlled trial of lithium carbonate in patients with amyotrophic lateral sclerosis (LiCALS) [Eudract number: 2008-006891-31].
P2860
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P2860
Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Lithium activates the serine/t ...... of Akt-1 activity in neurons.
@ast
Lithium activates the serine/t ...... of Akt-1 activity in neurons.
@en
type
label
Lithium activates the serine/t ...... of Akt-1 activity in neurons.
@ast
Lithium activates the serine/t ...... of Akt-1 activity in neurons.
@en
prefLabel
Lithium activates the serine/t ...... of Akt-1 activity in neurons.
@ast
Lithium activates the serine/t ...... of Akt-1 activity in neurons.
@en
P2860
P356
P1476
Lithium activates the serine/t ...... of Akt-1 activity in neurons.
@en
P2093
D M Chuang
E Chalecka-Franaszek
P2860
P304
P356
10.1073/PNAS.96.15.8745
P407
P577
1999-07-01T00:00:00Z