Exendin-4 increases islet amyloid deposition but offsets the resultant beta cell toxicity in human islet amyloid polypeptide transgenic mouse islets.
about
Mechanisms of islet amyloidosis toxicity in type 2 diabetesIncretins and amylin: neuroendocrine communication between the gut, pancreas, and brain in control of food intake and blood glucose.Accumulation of intrahepatic islet amyloid in a nonhuman primate transplant modelDetermination of Optimal Sample Size for Quantification of β-Cell Area, Amyloid Area and β-Cell Apoptosis in Isolated IsletsIslet Amyloid Polypeptide: Structure, Function, and Pathophysiology.Overall sulfation of heparan sulfate from pancreatic islet β-TC3 cells increases maximal fibril formation but does not determine binding to the amyloidogenic peptide islet amyloid polypeptideDegradation of islet amyloid polypeptide by neprilysin.Incretin therapy and islet pathology: a time for caution.Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics.Islet amyloid: from fundamental biophysics to mechanisms of cytotoxicity.One year of sitagliptin treatment protects against islet amyloid-associated β-cell loss and does not induce pancreatitis or pancreatic neoplasia in mice.Aggregation of islet amyloid polypeptide: from physical chemistry to cell biology.Diabetes and beta cell function: from mechanisms to evaluation and clinical implications.Inhibition of Insulin-Degrading Enzyme Does Not Increase Islet Amyloid Deposition in VitroThe ability of insulin to inhibit the formation of amyloid by pro-islet amyloid polypeptide processing intermediates is significantly reduced in the presence of sulfated glycosaminoglycans.Exendin-4 protects Aβ(1-42) oligomer-induced PC12 cell apoptosis.Islet amyloid deposits preferentially in the highly functional and most blood-perfused islets.The S20G substitution in hIAPP is more amyloidogenic and cytotoxic than wild-type hIAPP in mouse isletsIslet Amyloid Polypeptide Membrane Interactions: Effects of Membrane Composition.RAGE binds preamyloid IAPP intermediates and mediates pancreatic β cell proteotoxicity.The Receptor for Advanced Glycation Endproducts is a mediator of toxicity by IAPP and other proteotoxic aggregates: Establishing and Exploiting Common Ground for Novel Amyloidosis Therapies.The glucagon-like peptide-1 receptor agonist exenatide restores impaired pro-islet amyloid polypeptide processing in cultured human islets: implications in type 2 diabetes and islet transplantation.
P2860
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P2860
Exendin-4 increases islet amyloid deposition but offsets the resultant beta cell toxicity in human islet amyloid polypeptide transgenic mouse islets.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Exendin-4 increases islet amyl ...... ptide transgenic mouse islets.
@ast
Exendin-4 increases islet amyl ...... ptide transgenic mouse islets.
@en
type
label
Exendin-4 increases islet amyl ...... ptide transgenic mouse islets.
@ast
Exendin-4 increases islet amyl ...... ptide transgenic mouse islets.
@en
prefLabel
Exendin-4 increases islet amyl ...... ptide transgenic mouse islets.
@ast
Exendin-4 increases islet amyl ...... ptide transgenic mouse islets.
@en
P2093
P2860
P1433
P1476
Exendin-4 increases islet amyl ...... eptide transgenic mouse islets
@en
P2093
J Udayasankar
S L Subramanian
P2860
P2888
P304
P356
10.1007/S00125-011-2143-3
P577
2011-04-12T00:00:00Z