Glucose- and time-dependence of islet amyloid formation in vitro.
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The Rationale for Insulin Therapy in Alzheimer's DiseaseNeprilysin impedes islet amyloid formation by inhibition of fibril formation rather than peptide degradation.Inhibition of glycosaminoglycan synthesis and protein glycosylation with WAS-406 and azaserine result in reduced islet amyloid formation in vitro.Exendin-4 increases islet amyloid deposition but offsets the resultant beta cell toxicity in human islet amyloid polypeptide transgenic mouse islets.cJUN N-terminal kinase (JNK) activation mediates islet amyloid-induced beta cell apoptosis in cultured human islet amyloid polypeptide transgenic mouse islets.Determination of Optimal Sample Size for Quantification of β-Cell Area, Amyloid Area and β-Cell Apoptosis in Isolated IsletsOverall sulfation of heparan sulfate from pancreatic islet β-TC3 cells increases maximal fibril formation but does not determine binding to the amyloidogenic peptide islet amyloid polypeptideMatrix metalloproteinase-9 reduces islet amyloid formation by degrading islet amyloid polypeptideSmall interfering RNA-mediated suppression of proislet amyloid polypeptide expression inhibits islet amyloid formation and enhances survival of human islets in culture.Oxidative stress is induced by islet amyloid formation and time-dependently mediates amyloid-induced beta cell apoptosis.Pancreatic islet amyloidosis, beta-cell apoptosis, and alpha-cell proliferation are determinants of islet remodeling in type-2 diabetic baboons.Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stressAmyloid deposition in transplanted human pancreatic islets: a conceivable cause of their long-term failure.Apoptosis Repressor with Caspase Recruitment Domain Ameliorates Amyloid-Induced β-Cell Apoptosis and JNK Pathway Activation.Inhibition of Insulin-Degrading Enzyme Does Not Increase Islet Amyloid Deposition in VitroIslet amyloid deposits preferentially in the highly functional and most blood-perfused islets.IL-1 mediates amyloid-associated islet dysfunction and inflammation in human islet amyloid polypeptide transgenic mice.Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism.Extensive amyloid formation in transplanted microencapsulated mouse and human islets.
P2860
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P2860
Glucose- and time-dependence of islet amyloid formation in vitro.
description
2007 nî lūn-bûn
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2007年の論文
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2007年論文
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2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Glucose- and time-dependence of islet amyloid formation in vitro.
@ast
Glucose- and time-dependence of islet amyloid formation in vitro.
@en
type
label
Glucose- and time-dependence of islet amyloid formation in vitro.
@ast
Glucose- and time-dependence of islet amyloid formation in vitro.
@en
prefLabel
Glucose- and time-dependence of islet amyloid formation in vitro.
@ast
Glucose- and time-dependence of islet amyloid formation in vitro.
@en
P2093
P2860
P1476
Glucose- and time-dependence of islet amyloid formation in vitro.
@en
P2093
Fernando Gerchman
Jayalakshmi Udayasankar
Jenny Tong
Kristina M Utzschneider
Rebecca L Hull
Sakeneh Zraika
P2860
P304
P356
10.1016/J.BBRC.2006.12.187
P407
P577
2007-01-02T00:00:00Z