Neurotoxic effects induced by the Drosophila amyloid-beta peptide suggest a conserved toxic function.
about
Origins of amyloid-βThe circadian clock gene period extends healthspan in aging Drosophila melanogasterAnalysis of Amyloid Precursor Protein Function in Drosophila melanogasterCaenorhabditis elegans as a model organism to study APP functionNeurodegeneration in a Drosophila model for the function of TMCC2, an amyloid protein precursor-interacting and apolipoprotein E-binding proteinNebula/DSCR1 upregulation delays neurodegeneration and protects against APP-induced axonal transport defects by restoring calcineurin and GSK-3β signalingRole of Drosophila Amyloid Precursor Protein in Memory FormationOcular indicators of Alzheimer's: exploring disease in the retinaModeling the complex pathology of Alzheimer's disease in DrosophilaCharacterization of a Drosophila Alzheimer's disease model: pharmacological rescue of cognitive defectsA tale of two drug targets: the evolutionary history of BACE1 and BACE2Presenilin controls kinesin-1 and dynein function during APP-vesicle transport in vivoFoxO mediates APP-induced AICD-dependent cell death.Amyloid Precursor Proteins Are Dynamically Trafficked and Processed during Neuronal Development.Dictyostelium possesses highly diverged presenilin/gamma-secretase that regulates growth and cell-fate specification and can accurately process human APP: a system for functional studies of the presenilin/gamma-secretase complex.Apolipoprotein E-mimetics inhibit neurodegeneration and restore cognitive functions in a transgenic Drosophila model of Alzheimer's diseasePharmacological analysis of Drosophila melanogaster gamma-secretase with respect to differential proteolysis of Notch and APP.Transgenic Drosophila models of Alzheimer's disease and tauopathiesAmyloid precursor proteins are protective in Drosophila models of progressive neurodegeneration.PI3 kinase signaling is involved in Abeta-induced memory loss in Drosophila.Drosophila melanogaster in the study of human neurodegeneration.Drosophila melanogaster as a model organism for Alzheimer's disease.A translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: isradipine as a candidate drug.Manipulations of amyloid precursor protein cleavage disrupt the circadian clock in aging Drosophila.Amyloid-β Peptide Exacerbates the Memory Deficit Caused by Amyloid Precursor Protein Loss-of-Function in Drosophila.Drosophila models of proteinopathies: the little fly that could.Bidirectional Regulation of Amyloid Precursor Protein-Induced Memory Defects by Nebula/DSCR1: A Protein Upregulated in Alzheimer's Disease and Down SyndromeHibris, a Drosophila nephrin homolog, is required for presenilin-mediated Notch and APP-like cleavages.Glial expression of Swiss cheese (SWS), the Drosophila orthologue of neuropathy target esterase (NTE), is required for neuronal ensheathment and functionAmyloid precursor proteins interact with the heterotrimeric G protein Go in the control of neuronal migrationModeling Alzheimer's disease: from past to futureDistinctive roles of different beta-amyloid 42 aggregates in modulation of synaptic functions.Recent advances in using Drosophila to model neurodegenerative diseases.Understanding the molecular basis of Alzheimer's disease using a Caenorhabditis elegans model system.β-secretase cleavage of the fly amyloid precursor protein is required for glial survivalDevelopment of a Reporter System for In Vivo Monitoring of γ-Secretase Activity in Drosophila.The central molecular clock is robust in the face of behavioural arrhythmia in a Drosophila model of Alzheimer's disease.Alzheimer's disease and tauopathy studies in flies and worms.Analysis of amyloid precursor protein function in Drosophila melanogaster.Modeling human neurodegenerative diseases in transgenic systems.
P2860
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P2860
Neurotoxic effects induced by the Drosophila amyloid-beta peptide suggest a conserved toxic function.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Neurotoxic effects induced by ...... st a conserved toxic function.
@ast
Neurotoxic effects induced by ...... st a conserved toxic function.
@en
type
label
Neurotoxic effects induced by ...... st a conserved toxic function.
@ast
Neurotoxic effects induced by ...... st a conserved toxic function.
@en
prefLabel
Neurotoxic effects induced by ...... st a conserved toxic function.
@ast
Neurotoxic effects induced by ...... st a conserved toxic function.
@en
P2093
P2860
P1476
Neurotoxic effects induced by ...... st a conserved toxic function.
@en
P2093
Burkhard Poeck
Doris Kretzschmar
Jakob Tschäpe
Katia Carmine-Simmen
Roland Strauss
Thomas Proctor
Tilman Triphan
P2860
P304
P356
10.1016/J.NBD.2008.10.014
P577
2008-11-08T00:00:00Z