Rapid phospho-turnover by receptor tyrosine kinases impacts downstream signaling and drug binding.
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Orchestration of ErbB3 signaling through heterointeractions and homointeractions.Phosphotyrosine signaling proteins that drive oncogenesis tend to be highly interconnectedNetwork Architecture Predisposes an Enzyme to Either Pharmacologic or Genetic Targeting.Models of signalling networks - what cell biologists can gain from them and give to themFast rebinding increases dwell time of Src homology 2 (SH2)-containing proteins near the plasma membrane.Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals.Emission tuning of fluorescent kinase inhibitors: conjugation length and substituent effects.In silico labeling reveals the time-dependent label half-life and transit-time in dynamical systems.Programming biological models in Python using PySBHigher-order assemblies in a new paradigm of signal transduction.Receptor tyrosine kinases with intracellular pseudokinase domainsSingle-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo.Dual coordination of post translational modifications in human protein networks.Systems model of T cell receptor proximal signaling reveals emergent ultrasensitivity.Minocycline suppresses interleukine-6, its receptor system and signaling pathways and impairs migration, invasion and adhesion capacity of ovarian cancer cells: in vitro and in vivo studies.Epidermal growth factor receptor down-regulation triggers human myoblast differentiationAnalytical reduction of combinatorial complexity arising from multiple protein modification sites.How IGF-1 activates its receptor.Use of mechanistic models to integrate and analyze multiple proteomic datasetsSite-Specific Phosphorylation of VEGFR2 Is Mediated by Receptor Trafficking: Insights from a Computational ModelThe AXL Receptor is a Sensor of Ligand Spatial HeterogeneityMolecular mechanism matters: Benefits of mechanistic computational models for drug development.Perspective: Dynamics of receptor tyrosine kinase signaling complexesPTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena.Understanding cytokine and growth factor receptor activation mechanisms.The Dark Side of Cell Signaling: Positive Roles for Negative Regulators.Exploring higher-order EGFR oligomerisation and phosphorylation--a combined experimental and theoretical approach.Effect of Spatial Inhomogeneities on the Membrane Surface on Receptor Dimerization and Signal Initiation.Dynamic transition states of ErbB1 phosphorylation predicted by spatial stochastic modelingRule-based modeling: a computational approach for studying biomolecular site dynamics in cell signaling systems.EGFR-targeted therapy results in dramatic early lung tumor regression accompanied by imaging response and immune infiltration in EGFR mutant transgenic mouse models.EGFR induces DNA decomposition via phosphodiester bond cleavageThe genesis of tyrosine phosphorylation.Computational approaches for analyzing information flow in biological networks.Spatial regulation of receptor tyrosine kinases in development and cancer.Approaches to in vitro tissue regeneration with application for human disease modeling and drug development.Integrative biology of T cell activation.Signal transduction: From the atomic age to the post-genomic eraReceptor Level Mechanisms Are Required for Epidermal Growth Factor (EGF)-stimulated Extracellular Signal-regulated Kinase (ERK) Activity PulsesSH2 Binding Site Protection Assay: A Method for Identification of SH2 Domain Interaction Partners by Exploiting SH2 Mediated Phosphosite Protection.
P2860
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P2860
Rapid phospho-turnover by receptor tyrosine kinases impacts downstream signaling and drug binding.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Rapid phospho-turnover by rece ...... am signaling and drug binding.
@ast
Rapid phospho-turnover by rece ...... am signaling and drug binding.
@en
type
label
Rapid phospho-turnover by rece ...... am signaling and drug binding.
@ast
Rapid phospho-turnover by rece ...... am signaling and drug binding.
@en
prefLabel
Rapid phospho-turnover by rece ...... am signaling and drug binding.
@ast
Rapid phospho-turnover by rece ...... am signaling and drug binding.
@en
P2093
P2860
P1433
P1476
Rapid phospho-turnover by rece ...... am signaling and drug binding.
@en
P2093
Holger Conzelmann
Laura B Kleiman
Peter K Sorger
Thomas Maiwald
P2860
P304
P356
10.1016/J.MOLCEL.2011.07.014
P577
2011-09-01T00:00:00Z