The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors. - Wikidata - wikimedia - TriplyDB

The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors.

The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors.

http://www.wikidata.org/entity/Q35572396

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Biomarkers of residual disease, disseminated tumor cells, and metastases in the MMTV-PyMT breast cancer model The Androgen Receptor Bridges Stem Cell-Associated Signaling Nodes in Prostate Stem Cells Common stemness regulators of embryonic and cancer stem cells Identifying and targeting tumor-initiating cells in the treatment of breast cancer Obesity, metabolic dysregulation, and cancer: a growing concern and an inflammatory (and microenvironmental) issue Targeting SH2 domains in breast cancer Hwanggeumchal sorghum induces cell cycle arrest, and suppresses tumor growth and metastasis through Jak2/STAT pathways in breast cancer xenografts PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations Molecular targets in urothelial cancer: detection, treatment, and animal models of bladder cancer A novel five gene signature derived from stem-like side population cells predicts overall and recurrence-free survival in NSCLC Buoyancy-activated cell sorting using targeted biotinylated albumin microbubbles.STAT3-mediated autophagy dependence identifies subtypes of breast cancer where autophagy inhibition can be efficacious.Chitosan promotes cancer progression and stem cell properties in association with Wnt signaling in colon and hepatocellular carcinoma cells.Honokiol inhibits epithelial-mesenchymal transition in breast cancer cells by targeting signal transducer and activator of transcription 3/Zeb1/E-cadherin axis.Targeting oncogenic vulnerabilities in triple negative breast cancer: biological bases and ongoing clinical studies.Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor α signalling and results in tamoxifen insensitive proliferation STAT3 and epithelial-mesenchymal transitions in carcinomas Salinomycin Abolished STAT3 and STAT1 Interactions and Reduced Telomerase Activity in Colorectal Cancer Cells.HER2 in Breast Cancer Stemness: A Negative Feedback Loop towards Trastuzumab Resistance.Top Notch cancer stem cells by paracrine NF-κB signaling in breast cancer.Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease.Biomarkers to Target Heterogeneous Breast Cancer Stem Cells Transcription Factor STAT3 as a Novel Molecular Target for Cancer Prevention.Novel therapeutic strategies in the treatment of triple-negative breast cancer.Concurrent CD44s and STAT3 expression in human clear cell renal cellular carcinoma and its impact on survival Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway.A chemical biology approach to developing STAT inhibitors: molecular strategies for accelerating clinical translation Bone marrow endothelium-targeted therapeutics for metastatic breast cancer Targeting autophagy in breast cancer.Chloroquine eliminates cancer stem cells through deregulation of Jak2 and DNMT1.Bioinformatic analysis reveals a pattern of STAT3-associated gene expression specific to basal-like breast cancers in human tumors Clinical potential of novel therapeutic targets in breast cancer: CDK4/6, Src, JAK/STAT, PARP, HDAC, and PI3K/AKT/mTOR pathways.ARF and p53 coordinate tumor suppression of an oncogenic IFN-β-STAT1-ISG15 signaling axis.TLR9 is critical for glioma stem cell maintenance and targeting.Surgery-induced wound response promotes stem-like and tumor-initiating features of breast cancer cells, via STAT3 signaling Therapeutic CK2 inhibition attenuates diverse prosurvival signaling cascades and decreases cell viability in human breast cancer cells.The transcriptional modulator BCL6 as a molecular target for breast cancer therapy Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer.Acylglycerol kinase augments JAK2/STAT3 signaling in esophageal squamous cells

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The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors.

http://www.wikidata.org/entity/Q35572396

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The JAK2/STAT3 signaling pathw ...... cancer cells in human tumors.

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The JAK2/STAT3 signaling pathw ...... cancer cells in human tumors.

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The JAK2/STAT3 signaling pathw ...... cancer cells in human tumors.

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Andrea L Richardson

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Andriy Marusyk

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David A Frank

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David E Root

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Hee Eun Lee

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Janina Schemme

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Jessica J Kim

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Karen S Anderson

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Kornelia Polyak

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Laura A Mulvey

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P2860

The CD44+/CD24- phenotype is enriched in basal-like breast tumors

The ubiquitin-like molecule interferon-stimulated gene 15 (ISG15) is a potential prognostic marker in human breast cancer

Cancer as an evolutionary and ecological process

STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells

Aspirin intake and survival after breast cancer

CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts

A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes

An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation

IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland

Prospective identification of tumorigenic breast cancer cells

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2723-2735

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10.1172/JCI44745

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121

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3223826

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