The activation mechanism of rat vanilloid receptor 1 by capsaicin involves the pore domain and differs from the activation by either acid or heat.
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TRPV1: on the road to pain reliefEffects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1)Acidification of rat TRPV1 alters the kinetics of capsaicin responses.TRPM3 in temperature sensing and beyondFunctionally important amino acid residues in the transient receptor potential vanilloid 1 (TRPV1) ion channel--an overview of the current mutational dataVanilloid receptors in hearing: altered cochlear sensitivity by vanilloids and expression of TRPV1 in the organ of corti.Membrane Protein Properties Revealed through Data-Rich Electrostatics Calculations.Effect of cholesterol depletion on the pore dilation of TRPV1.Regulation of acid signaling in rat pulmonary sensory neurons by protease-activated receptor-2.Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia.Kinetic and energetic analysis of thermally activated TRPV1 channelsCapsaicin activation of the pain receptor, VR1: multiple open states from both partial and full binding.Thermodynamics of heat activation of single capsaicin ion channels VR1.Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell lineSensory neurone responses to mucosal noxae in the upper gut: relevance to mucosal integrity and gastrointestinal pain.'Entourage' effects of N-acyl ethanolamines at human vanilloid receptors. Comparison of effects upon anandamide-induced vanilloid receptor activation and upon anandamide metabolismAcid-sensitive ion channels and receptorsCapsaicin interaction with TRPV1 channels in a lipid bilayer: molecular dynamics simulation.Cardiovascular regulation by skeletal muscle reflexes in health and disease.Molecular architecture of the vanilloid receptor. Insights for drug design.A role for the anandamide membrane transporter in TRPV1-mediated neurosecretion from trigeminal sensory neurons.Proton block of proton-activated TRPV1 current.N-glycosylation determines ionic permeability and desensitization of the TRPV1 capsaicin receptor.Intracellular proton-mediated activation of TRPV3 channels accounts for the exfoliation effect of α-hydroxyl acids on keratinocytes.Muscle reflex in heart failure: the role of exercise training.Low pH potentiates both capsaicin binding and channel gating of VR1 receptors.Optogenetic approaches addressing extracellular modulation of neural excitability.The pharmacological challenge to tame the transient receptor potential vanilloid-1 (TRPV1) nocisensorTransient receptor potential vanilloid channels in hypertension, inflammation, and end organ damage: an imminent target of therapy for cardiovascular disease?Proton inhibition of unitary currents of vanilloid receptors.The transient receptor potential vanilloid-1 channel in thermoregulation: a thermosensor it is not.Transient receptor potential channels in pain and inflammation: therapeutic opportunities.Alcohol-binding sites in distinct brain proteins: the quest for atomic level resolution.Transient receptor potential channels in bladder function.Molecular mechanism of TRP channelsProtein kinase C(alpha) is required for vanilloid receptor 1 activation. Evidence for multiple signaling pathways.A fast solution switching system with temperature control for single cell measurements.Toward elucidating the heat activation mechanism of the TRPV1 channel gating by molecular dynamics simulation.Tunable calcium current through TRPV1 receptor channelsPolyamines are potent ligands for the capsaicin receptor TRPV1.
P2860
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P2860
The activation mechanism of rat vanilloid receptor 1 by capsaicin involves the pore domain and differs from the activation by either acid or heat.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
The activation mechanism of ra ...... vation by either acid or heat.
@ast
The activation mechanism of ra ...... vation by either acid or heat.
@en
type
label
The activation mechanism of ra ...... vation by either acid or heat.
@ast
The activation mechanism of ra ...... vation by either acid or heat.
@en
prefLabel
The activation mechanism of ra ...... vation by either acid or heat.
@ast
The activation mechanism of ra ...... vation by either acid or heat.
@en
P2093
P2860
P356
P1476
The activation mechanism of ra ...... vation by either acid or heat.
@en
P2093
P H Reinhart
P2860
P304
13889-13894
P356
10.1073/PNAS.230146497
P407
P577
2000-12-01T00:00:00Z