Insulin action is blocked by a monoclonal antibody that inhibits the insulin receptor kinase
about
Microinjection of a protein-tyrosine-phosphatase inhibits insulin action in Xenopus oocytesUptake and binding of radiolabelled phenylarsine oxide in 3T3-L1 adipocytesA monoclonal anti-peptide antibody reacting with the insulin receptor beta-subunit. Characterization of the antibody and its epitope and use in immunoaffinity purification of intact receptorsProperties of the insulin receptor ectodomainActivation of glucose uptake by insulin and insulin-like growth factor I in Xenopus oocytesMonoclonal antibodies to the insulin receptor stimulate the intrinsic tyrosine kinase activity by cross-linking receptor moleculesIn vivo stimulation of the insulin receptor kinase in human skeletal muscle. Correlation with insulin-stimulated glucose disposal during euglycemic clamp studiesIn situ autoradiography and ligand-dependent tyrosine kinase activity reveal insulin receptors and insulin-like growth factor I receptors in prepancreatic chicken embryosCharacterization of the endogenous insulin receptor-related receptor in neuroblastomas.Heterologous transmembrane signaling by a human insulin receptor-v-ros hybrid in Chinese hamster ovary cells.Activation of transforming potential of the human insulin receptor geneRole of insulin receptor phosphorylation in the insulinomimetic effects of hydrogen peroxide.Acute insulin action requires insulin receptor kinase activity: introduction of an inhibitory monoclonal antibody into mammalian cells blocks the rapid effects of insulin.Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity.Insulin stimulates phosphorylation of a 120-kDa glycoprotein substrate (pp120) for the receptor-associated protein kinase in intact H-35 hepatoma cells.Monoclonal antibodies to the human insulin receptor that activate glucose transport but not insulin receptor kinase activity.Insulin stimulates a membrane-bound serine kinase that may be phosphorylated on tyrosineTranslocation of globin fusion proteins across the endoplasmic reticulum membrane in Xenopus laevis oocytes.Monoclonal antibody to the thrombin receptor stimulates DNA synthesis in combination with gamma-thrombin or phorbol myristate acetateFunctional reconstitutional of the human epidermal growth factor receptor system in Xenopus oocytes.Effect of microinjection of a low-Mr human placenta protein tyrosine phosphatase on induction of meiotic cell division in Xenopus oocytesInsulin-stimulated oocyte maturation requires insulin receptor substrate 1 and interaction with the SH2 domains of phosphatidylinositol 3-kinase.Growth-stimulatory monoclonal antibodies against human insulin-like growth factor I receptorThe antibiotic azatyrosine suppresses progesterone or [Val12]p21 Ha-ras/insulin-like growth factor I-induced germinal vesicle breakdown and tyrosine phosphorylation of Xenopus mitogen-activated protein kinase in oocytes.Molecular basis of the activation of the tumorigenic potential of Gag-insulin receptor chimeras.Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyrosine kinase activityLinking functional domains of the human insulin receptor with the bacterial aspartate receptorInjection of an antibody against a p21 c-Ha-ras protein inhibits cleavage in axolotl eggsAntibodies directed to the insulin receptor. Clinical aspects and applications to the study of insulin action.Antibodies to the insulin receptor as tools in the study of receptor structure and function.Phosphotyrosyl protein phosphatases.The insulin receptor: structure and function.Efficient expression in insect cells of a soluble, active human insulin receptor protein-tyrosine kinase domain by use of a baculovirus vector.Use of an anti-insulin receptor antibody to discriminate between metabolic and mitogenic effects of insulin: correlation with receptor autophosphorylation.Analysis of insulin receptor phosphorylation sites in intact rat liver cells by two-dimensional phosphopeptide mapping. Predominance of the tris-phosphorylated form of the kinase domain after stimulation by insulin.Phosphorylation in vitro of the 85 kDa subunit of phosphatidylinositol 3-kinase and its possible activation by insulin receptor tyrosine kinase.Epidermal growth factor mimics insulin effects in rat hepatocytes.Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytesInhibitory effect of fluoride on insulin receptor autophosphorylation and tyrosine kinase activitySecretion of the extracellular domain of the human insulin receptor from insect cells by use of a baculovirus vector.
P2860
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P2860
Insulin action is blocked by a monoclonal antibody that inhibits the insulin receptor kinase
description
1986 nî lūn-bûn
@nan
1986年の論文
@ja
1986年論文
@yue
1986年論文
@zh-hant
1986年論文
@zh-hk
1986年論文
@zh-mo
1986年論文
@zh-tw
1986年论文
@wuu
1986年论文
@zh
1986年论文
@zh-cn
name
Insulin action is blocked by a ...... ts the insulin receptor kinase
@ast
Insulin action is blocked by a ...... ts the insulin receptor kinase
@en
type
label
Insulin action is blocked by a ...... ts the insulin receptor kinase
@ast
Insulin action is blocked by a ...... ts the insulin receptor kinase
@en
prefLabel
Insulin action is blocked by a ...... ts the insulin receptor kinase
@ast
Insulin action is blocked by a ...... ts the insulin receptor kinase
@en
P2093
P2860
P356
P1476
Insulin action is blocked by a ...... ts the insulin receptor kinase
@en
P2093
P2860
P304
P356
10.1073/PNAS.83.2.328
P407
P577
1986-01-01T00:00:00Z