about
Isolation and chromosomal localization of the human fgr protooncogene, a distinct member of the tyrosine kinase gene family1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cellsPhotoaffinity labelling of the ATP-binding site of the epidermal growth factor-dependent protein kinasebeta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transportDecreased phosphorylation of mutant insulin receptor by protein kinase C and protein kinase A.A complex of GRB2-dynamin binds to tyrosine-phosphorylated insulin receptor substrate-1 after insulin treatment.All-Atom Structural Models of the Transmembrane Domains of Insulin and Type 1 Insulin-Like Growth Factor ReceptorsATP sensitizes the insulin receptor to insulinInsulin and rabbit anti-insulin receptor antibodies stimulate additively the intrinsic receptor kinase activity.Studies on the mechanism of insulin resistance in the liver from humans with noninsulin-dependent diabetes. Insulin action and binding in isolated hepatocytes, insulin receptor structure, and kinase activity.Role of insulin receptor phosphorylation in the insulinomimetic effects of hydrogen peroxide.Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes.Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity.Insulin binding to human B lymphoblasts is a function of HLA haplotype.Insulin-activated tyrosine phosphorylation of a 15-kilodalton protein in intact 3T3-L1 adipocytesStructural analysis of normal and mutant insulin receptors in fibroblasts cultured from families with leprechaunism.Insulin receptors in isolated human adipocytes. Characterization by photoaffinity labeling and evidence for internalization and cellular processing.Insulin action is blocked by a monoclonal antibody that inhibits the insulin receptor kinaseClass I histocompatibility antigens and insulin receptors: evidence for interactionsAbnormality of insulin binding and receptor phosphorylation in an insulin-resistant melanoma cell line.Tyrosyl kinases acquired from anchorage-independent cells by a membrane-enveloped virusProgesterone receptor subunits are high-affinity substrates for phosphorylation by epidermal growth factor receptor.Insulin receptor is an insulin-dependent tyrosine protein kinase: copurification of insulin-binding activity and protein kinase activity to homogeneity from human placentaNovel roles for insulin receptor (IR) in adipocytes and skeletal muscle cells via new and unexpected substrates.Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation.The early effect of sunitinib on insulin clearance in patients with metastatic renal cell carcinomaAbundant constitutive expression of the immediate-early 94K protein from cytomegalovirus (Colburn) in a DNA-transfected mouse cell line.Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyrosine kinase activityDifferential sensitivity of two functions of the insulin receptor to the associated proteolysis: kinase action and hormone bindingThe monomeric alpha beta form of the insulin receptor exhibits much higher insulin-dependent tyrosine-specific protein kinase activity than the intact alpha 2 beta 2 form of the receptor.An antipeptide antibody that specifically inhibits insulin receptor autophosphorylation and protein kinase activity.Expression of a functional human insulin receptor from a cloned cDNA in Chinese hamster ovary cells.Identification of the alpha beta monomer of the adipocyte insulin receptor by insulin binding and autophosphorylation.Tyrosine-specific protein kinase activity is associated with the purified insulin receptor.Evidence that a 90-kDa phosphoprotein, an associated kinase, and a specific phosphatase are involved in the regulation of Cloudman melanoma cell proliferation by insulin.Protein kinase activity associated with the purified rat hepatic glucocorticoid receptor.Antibodies directed to the insulin receptor. Clinical aspects and applications to the study of insulin action.The IGF system.Antibodies to the insulin receptor as tools in the study of receptor structure and function.The insulin receptor: structure and function.
P2860
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P2860
description
1983 nî lūn-bûn
@nan
1983 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1983 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1983年の論文
@ja
1983年論文
@yue
1983年論文
@zh-hant
1983年論文
@zh-hk
1983年論文
@zh-mo
1983年論文
@zh-tw
1983年论文
@wuu
name
Insulin receptor: evidence that it is a protein kinase
@ast
Insulin receptor: evidence that it is a protein kinase
@en
Insulin receptor: evidence that it is a protein kinase
@en-gb
Insulin receptor: evidence that it is a protein kinase
@nl
type
label
Insulin receptor: evidence that it is a protein kinase
@ast
Insulin receptor: evidence that it is a protein kinase
@en
Insulin receptor: evidence that it is a protein kinase
@en-gb
Insulin receptor: evidence that it is a protein kinase
@nl
prefLabel
Insulin receptor: evidence that it is a protein kinase
@ast
Insulin receptor: evidence that it is a protein kinase
@en
Insulin receptor: evidence that it is a protein kinase
@en-gb
Insulin receptor: evidence that it is a protein kinase
@nl
P921
P3181
P356
P1433
P1476
Insulin receptor: evidence that it is a protein kinase
@en
P2093
P304
P3181
P356
10.1126/SCIENCE.6849137
P407
P577
1983-01-21T00:00:00Z