The use of deuterium isotope effects to probe the active site properties, mechanism of cytochrome P450-catalyzed reactions, and mechanisms of metabolically dependent toxicity.
about
Discovery of (R)-(2-fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl) (3-hydroxypiperidin-1-yl)methanone (ML337), an mGlu3 selective and CNS penetrant negative allosteric modulator (NAM)Oxidative cleavage of diverse ethers by an extracellular fungal peroxygenaseInsights into the catalytic mechanisms of phenylalanine and tryptophan hydroxylase from kinetic isotope effects on aromatic hydroxylationUnderstanding a substrate's product regioselectivity in a family of enzymes: a case study of acetaminophen binding in cytochrome P450sApplications of stable isotopes in clinical pharmacologySingle mutations change CYP2F3 from a dehydrogenase of 3-methylindole to an oxygenase.Differentiation of antiinflammatory and antitumorigenic properties of stabilized enantiomers of thalidomide analogsApplications of stereospecifically-labeled Fatty acids in oxygenase and desaturase biochemistryCombinatorial synthesis of deuterium-enriched (S)-oxybutynin.Minor activities and transition state properties of the human steroid hydroxylases cytochromes P450c17 and P450c21, from reactions observed with deuterium-labeled substrates.Synthesis of deuterium-enriched and fluorine-substituted plinabulin derivatives and evaluation of their antitumor activities.Selective hydroxylation of alkanes by an extracellular fungal peroxygenase.Protein targets of reactive metabolites of thiobenzamide in rat liver in vivoA comparison of substrate dynamics in human CYP2E1 and CYP2A6Applications of mass spectrometry in drug metabolism: 50 years of progress.Mechanism of Catalytic Water Oxidation by the Ruthenium Blue Dimer Catalyst: Comparative Study in D₂O versus H₂O.Hybrid in silico models for drug-induced liver injury using chemical descriptors and in vitro cell-imaging information.In vitro and in vivo Evaluation of CYP1A Interaction Potential of Terminalia Arjuna Bark.Continuous-Flow Synthesis of Deuterium-Labeled Antidiabetic Chalcones: Studies towards the Selective Deuteration of the Alkynone Core.Stable isotope labeling strategy for curcumin metabolite study in human liver microsomes by liquid chromatography-tandem mass spectrometry.Intrinsic isotope effects on benzylic hydroxylation by the aromatic amino acid hydroxylases: evidence for hydrogen tunneling, coupled motion, and similar reactivities.Nickel-Catalyzed Reduction of Secondary and Tertiary Amides.European Bioanalysis Forum recommendation: scientific validation of quantification by accelerator mass spectrometry.A facile synthesis of 5,5-dideutero-4-dimethyl(phenyl)silyl-6-undecyl-tetrahydropyran-2-one as a deuterium labeled synthon for (-)-tetrahydrolipstatin and (+)-δ-hexadecanolide.Cytochrome P450 and Non-Cytochrome P450 Oxidative Metabolism: Contributions to the Pharmacokinetics, Safety, and Efficacy of Xenobiotics.CYP725A4 from yew catalyzes complex structural rearrangement of taxa-4(5),11(12)-diene into the cyclic ether 5(12)-oxa-3(11)-cyclotaxane.Oxygen Activation and Radical Transformations in Heme Proteins and Metalloporphyrins.Deuterium- and Tritium-Labelled Compounds: Applications in the Life Sciences.Effect of N-methyl deuteration on pharmacokinetics and pharmacodynamics of enzalutamide.Kinetic Deuterium Isotope Effects in Cytochrome P450 Reactions.Pharmacokinetics, metabolism and safety of deuterated L-DOPA (SD-1077)/carbidopa compared to L-DOPA/carbidopa following single oral dose administration in healthy subjects
P2860
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P2860
The use of deuterium isotope effects to probe the active site properties, mechanism of cytochrome P450-catalyzed reactions, and mechanisms of metabolically dependent toxicity.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
The use of deuterium isotope e ...... abolically dependent toxicity.
@ast
The use of deuterium isotope e ...... abolically dependent toxicity.
@en
type
label
The use of deuterium isotope e ...... abolically dependent toxicity.
@ast
The use of deuterium isotope e ...... abolically dependent toxicity.
@en
prefLabel
The use of deuterium isotope e ...... abolically dependent toxicity.
@ast
The use of deuterium isotope e ...... abolically dependent toxicity.
@en
P356
P1476
The use of deuterium isotope e ...... abolically dependent toxicity.
@en
P2093
Sidney D Nelson
William F Trager
P304
P356
10.1124/DMD.31.12.1481
P577
2003-12-01T00:00:00Z