Smurf1 facilitates myogenic differentiation and antagonizes the bone morphogenetic protein-2-induced osteoblast conversion by targeting Smad5 for degradation.
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Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3Ubiquitination of RhoA by Smurf1 promotes neurite outgrowthUbiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradationMicroRNA-214 promotes myogenic differentiation by facilitating exit from mitosis via down-regulation of proto-oncogene N-rasHECT E3s and human disease.Development and optimization of a cell-based assay for the selection of synthetic compounds that potentiate bone morphogenetic protein-2 activity.Selective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradationRoles of E3 ubiquitin ligases in cell adhesion and migration.Proteomic analysis of sera of asymptomatic, early-stage patients with Wilson's disease.LIM mineralization protein-1 potentiates bone morphogenetic protein responsiveness via a novel interaction with Smurf1 resulting in decreased ubiquitination of Smads.Pivotal role of the C2 domain of the Smurf1 ubiquitin ligase in substrate selectionUbiquitin-dependent regulation of TGFbeta signaling in cancerSmurf1 inhibits mesenchymal stem cell proliferation and differentiation into osteoblasts through JunB degradation.Strategies to minimize hypertrophy in cartilage engineering and regeneration.Regulation of the TGFbeta signalling pathway by ubiquitin-mediated degradation.Identification of C-terminal Hsp70-interacting protein as a mediator of tumour necrosis factor action in osteoblast differentiation by targeting osterix for degradationFunctional redundancy of type II BMP receptor and type IIB activin receptor in BMP2-induced osteoblast differentiationUbiquitination of tumor necrosis factor receptor-associated factor 4 (TRAF4) by Smad ubiquitination regulatory factor 1 (Smurf1) regulates motility of breast epithelial and cancer cellsSmad ubiquitination regulatory factor 2 promotes metastasis of breast cancer cells by enhancing migration and invasiveness.Transforming growth factor-beta signaling and ubiquitinators in cancer.Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts.Smurf1 inhibits osteoblast differentiation and bone formation in vitro and in vivo.Tumor necrosis factor-receptor-associated factor-4 is a positive regulator of transforming growth factor-beta signaling that affects neural crest formation.A negative feedback control of transforming growth factor-beta signaling by glycogen synthase kinase 3-mediated Smad3 linker phosphorylation at Ser-204.Smurf control in bone cells.Regulation of the transforming growth factor β pathway by reversible ubiquitylation.MicroRNA expression analysis during FK506-induced osteogenic differentiation in rat bone marrow stromal cellsE3 ubiquitin ligases in regulating stress fiber, lamellipodium, and focal adhesion dynamics.Uev1A facilitates osteosarcoma differentiation by promoting Smurf1-mediated Smad1 ubiquitination and degradation.The function and interrelationship between GDF5 and ERG-010 during chondrogenesis in vitro.Bradykinin regulates osteoblast differentiation by Akt/ERK/NFκB signaling axis.Tumor necrosis factor-α enhances the transcription of Smad ubiquitination regulatory factor 1 in an activating protein-1- and Runx2-dependent manner.Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases.ZC4H2 stabilizes Smads to enhance BMP signalling, which is involved in neural development in Xenopus.Smurf1 regulates neural patterning and folding in Xenopus embryos by antagonizing the BMP/Smad1 pathway.A novel regulatory mechanism of the bone morphogenetic protein (BMP) signaling pathway involving the carboxyl-terminal tail domain of BMP type II receptor.Involvement of BMPs/Smad signaling pathway in mechanical response in osteoblasts.Molecular interaction between Smurf1 WW2 domain and PPXY motifs of Smad1, Smad5, and Smad6--modeling and analysis.Smad5
P2860
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P2860
Smurf1 facilitates myogenic differentiation and antagonizes the bone morphogenetic protein-2-induced osteoblast conversion by targeting Smad5 for degradation.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Smurf1 facilitates myogenic di ...... rgeting Smad5 for degradation.
@ast
Smurf1 facilitates myogenic di ...... rgeting Smad5 for degradation.
@en
type
label
Smurf1 facilitates myogenic di ...... rgeting Smad5 for degradation.
@ast
Smurf1 facilitates myogenic di ...... rgeting Smad5 for degradation.
@en
prefLabel
Smurf1 facilitates myogenic di ...... rgeting Smad5 for degradation.
@ast
Smurf1 facilitates myogenic di ...... rgeting Smad5 for degradation.
@en
P2093
P2860
P356
P1476
Smurf1 facilitates myogenic di ...... rgeting Smad5 for degradation.
@en
P2093
Sai-Xia Ying
Ying E Zhang
Zareena J Hussain
P2860
P304
39029-39036
P356
10.1074/JBC.M301193200
P407
P577
2003-07-18T00:00:00Z