Caught in the act: alpha-synuclein is the culprit in Parkinson's disease.
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Structures of the E46K mutant-type α-synuclein protein and impact of E46K mutation on the structures of the wild-type α-synuclein proteinPutative Role of Red Wine Polyphenols against Brain Pathology in Alzheimer's and Parkinson's DiseasePrion diseases: immunotargets and therapyGlia and alpha-synuclein in neurodegeneration: A complex interactionImpaired c-Fos and polo-like kinase 2 induction in the limbic system of fear-conditioned α-synuclein transgenic miceMicroRNAs in NeurotoxicityExamining the relationship between head trauma and neurodegenerative disease: A review of epidemiology, pathology and neuroimaging techniquesRecognition of psychostimulants, antidepressants, and other inhibitors of synaptic neurotransmitter uptake by the plasma membrane monoamine transportersRepression of alpha-synuclein expression and toxicity by microRNA-7.Isolation of a human single chain antibody fragment against oligomeric alpha-synuclein that inhibits aggregation and prevents alpha-synuclein-induced toxicityProducts of Cu(II)-catalyzed oxidation of alpha-synuclein fragments containing M1-D2 and H50 residues in the presence of hydrogen peroxide.Ribosylation rapidly induces alpha-synuclein to form highly cytotoxic molten globules of advanced glycation end products.The neurotoxicity of DOPAL: behavioral and stereological evidence for its role in Parkinson disease pathogenesis.Mechanisms underlying extensive Ser129-phosphorylation in α-synuclein aggregates.Baicalein reduces E46K alpha-synuclein aggregation in vitro and protects cells against E46K alpha-synuclein toxicity in cell models of familiar Parkinsonism.A neuroprotective role for angiogenin in models of Parkinson's diseaseEffects of Various Flavonoids on the α-Synuclein Fibrillation Process.Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite architecture and nigrostriatal degeneration with potential to model tPrefoldin 5 is required for normal sensory and neuronal development in a murine model.Lewy bodies.Biochemical and morphological consequences of human α-synuclein expression in a mouse α-synuclein null background.Zonisamide attenuates α-synuclein neurotoxicity by an aggregation-independent mechanism in a rat model of familial Parkinson's diseaseMice lacking major brain gangliosides develop parkinsonismEndogenous neurotoxic dopamine derivative covalently binds to Parkinson's disease-associated ubiquitin C-terminal hydrolase L1 and alters its structure and function.SIRT1 protects against α-synuclein aggregation by activating molecular chaperonesLack of alpha-synuclein increases amyloid plaque accumulation in a transgenic mouse model of Alzheimer's disease.The ubiquitin proteasome system in synaptic and axonal degeneration: a new twist to an old cycle.Lewy-like aggregation of α-synuclein reduces protein phosphatase 2A activity in vitro and in vivo.Mechanisms of neuronal death in synucleinopathy.Alpha synuclein protein levels are increased in serum from recently abstinent cocaine abusersalpha-synuclein and Parkinson's disease: the first roadblock.Serine 129 phosphorylation of membrane-associated α-synuclein modulates dopamine transporter function in a G protein-coupled receptor kinase-dependent manner.Advances with microRNAs in Parkinson's disease research.Evidence for prion-like mechanisms in several neurodegenerative diseases: potential implications for immunotherapyα-Synuclein enhances histone H3 lysine-9 dimethylation and H3K9me2-dependent transcriptional responses.Loss of functional alpha-synuclein: a toxic event in Parkinson's disease?Active immunization therapies for Parkinson's disease and multiple system atrophy.Sensitive western blotting for detection of endogenous Ser129-phosphorylated α-synuclein in intracellular and extracellular spacesα-Synuclein nonhuman primate models of Parkinson's disease.Phosphorylated alpha-synuclein at Ser-129 is targeted to the proteasome pathway in a ubiquitin-independent manner
P2860
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P2860
Caught in the act: alpha-synuclein is the culprit in Parkinson's disease.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Caught in the act: alpha-synuclein is the culprit in Parkinson's disease.
@ast
Caught in the act: alpha-synuclein is the culprit in Parkinson's disease.
@en
type
label
Caught in the act: alpha-synuclein is the culprit in Parkinson's disease.
@ast
Caught in the act: alpha-synuclein is the culprit in Parkinson's disease.
@en
prefLabel
Caught in the act: alpha-synuclein is the culprit in Parkinson's disease.
@ast
Caught in the act: alpha-synuclein is the culprit in Parkinson's disease.
@en
P50
P1433
P1476
Caught in the act: alpha-synuclein is the culprit in Parkinson's disease.
@en
P304
P356
10.1016/S0896-6273(03)00684-6
P407
P577
2003-10-01T00:00:00Z