Erythroid Kruppel-like factor (EKLF) is recruited to the gamma-globin gene promoter as a co-activator and is required for gamma-globin gene induction by short-chain fatty acid derivatives
about
Novel Inducers of Fetal Globin Identified through High Throughput Screening (HTS) Are Active In Vivo in Anemic Baboons and Transgenic MiceNovel therapeutic candidates, identified by molecular modeling, induce γ-globin gene expression in vivo.Regulation of delta-aminolevulinic acid dehydratase by krüppel-like factor 1.Regulation of Gγ-globin gene by ATF2 and its associated proteins through the cAMP-response element.The multifunctional role of EKLF/KLF1 during erythropoiesis.Functional interactions between erythroid Krüppel-like factor (EKLF/KLF1) and protein phosphatase PPM1B/PP2CβButyrate histone deacetylase inhibitors.A phase 1/2 trial of HQK-1001, an oral fetal globin inducer, in sickle cell diseaseFetal globin gene inducers: novel agents and new potential.A randomized phase I/II trial of HQK-1001, an oral fetal globin gene inducer, in β-thalassaemia intermedia and HbE/β-thalassaemia.EKLF/KLF1, a tissue-restricted integrator of transcriptional control, chromatin remodeling, and lineage determination.Gamma reactivation using the spongy effect of KLF1-binding site sequence: an approach in gene therapy for beta-thalassemia.Epigenetic Treatment of Neuropsychiatric Disorders: Autism and Schizophrenia.Therapeutic fetal-globin inducers reduce transcriptional repression in hemoglobinopathy erythroid progenitors through distinct mechanisms.A dose-escalation phase IIa study of 2,2-dimethylbutyrate (HQK-1001), an oral fetal globin inducer, in sickle cell disease.Induction of fetal hemoglobin and ABCB1 gene expression in 9-β-D-arabinofuranosylguanine-resistant MOLT-4 cells.Induction of functional Brm protein from Brm knockout miceBioprotective carnitinoids: lipoic acid, butyrate, and mitochondria-targeting to treat radiation injury: mitochondrial drugs come of age.A reduced curcuminoid analog as a novel inducer of fetal hemoglobin.A double-blind, placebo-controlled phase II study of the efficacy and safety of 2,2-dimethylbutyrate (HQK-1001), an oral fetal globin inducer, in sickle cell disease.Development of phenotypic screening assays for γ-globin induction using primary human bone marrow day 7 erythroid progenitor cells.
P2860
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P2860
Erythroid Kruppel-like factor (EKLF) is recruited to the gamma-globin gene promoter as a co-activator and is required for gamma-globin gene induction by short-chain fatty acid derivatives
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Erythroid Kruppel-like factor ...... t-chain fatty acid derivatives
@ast
Erythroid Kruppel-like factor ...... t-chain fatty acid derivatives
@en
type
label
Erythroid Kruppel-like factor ...... t-chain fatty acid derivatives
@ast
Erythroid Kruppel-like factor ...... t-chain fatty acid derivatives
@en
prefLabel
Erythroid Kruppel-like factor ...... t-chain fatty acid derivatives
@ast
Erythroid Kruppel-like factor ...... t-chain fatty acid derivatives
@en
P2093
P2860
P1476
Erythroid Kruppel-like factor ...... t-chain fatty acid derivatives
@en
P2093
Douglas V Faller
James J Bieker
Michael S Boosalis
Rishikesh Mankidy
Susan P Perrine
P2860
P304
P356
10.1111/J.1600-0609.2009.01234.X
P577
2009-02-05T00:00:00Z