Fourth-generation epac-based FRET sensors for cAMP feature exceptional brightness, photostability and dynamic range: characterization of dedicated sensors for FLIM, for ratiometry and with high affinity
about
Genetically-encoded tools for cAMP probing and modulation in living systemsA Guide to Fluorescent Protein FRET PairscAMP-dependent cell differentiation triggered by activated CRHR1 in hippocampal neuronal cells.siFLIM: single-image frequency-domain FLIM provides fast and photon-efficient lifetime data.FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility.Schwann cells are activated by ATP released from neurons in an in vitro cellular model of Miller Fisher syndrome.A Perspective on Studying G-Protein-Coupled Receptor Signaling with Resonance Energy Transfer Biosensors in Living Organisms.Estimating the magnitude of near-membrane PDE4 activity in living cellsCa2+ influx through L-type Ca2+ channels and Ca2+-induced Ca2+ release regulate cAMP accumulation and Epac1-dependent ERK 1/2 activation in INS-1 cells.A cardiac mitochondrial cAMP signaling pathway regulates calcium accumulation, permeability transition and cell deathIntracellular tortuosity underlies slow cAMP diffusion in adult ventricular myocytes.Different cAMP sources are critically involved in G protein-coupled receptor CRHR1 signaling.Exploring cells with targeted biosensorsRegulation of neurite morphogenesis by interaction between R7 regulator of G protein signaling complexes and G protein subunit Gα13.Integrated Strategies to Gain a Systems-Level View of Dynamic Signaling Networks.Open Source High Content Analysis Utilizing Automated Fluorescence Lifetime Imaging Microscopy.Interrogating cyclic AMP signaling using optical approaches.Dysregulation of Neuronal Ca2+ Channel Linked to Heightened Sympathetic Phenotype in Prohypertensive StatesCharacterization of a spectrally diverse set of fluorescent proteins as FRET acceptors for mTurquoise2.Dynamic monitoring of Gi/o-protein-mediated decreases of intracellular cAMP by FRET-based Epac sensorsDistinct Conformational Dynamics of Three G Protein-Coupled Receptors Measured Using FlAsH-BRET BiosensorsActivation of PKA in cell requires higher concentration of cAMP than in vitro: implications for compartmentalization of cAMP signallingATP Released by Injured Neurons Activates Schwann Cells.Cigarette smoke activates CFTR through ROS-stimulated cAMP signaling in human bronchial epithelial cells.Red fluorescent cAMP indicator with increased affinity and expanded dynamic range.Imaging of PDE2- and PDE3-Mediated cGMP-to-cAMP Cross-Talk in Cardiomyocytes.Overcoming limitations of FRET measurements.Quantitative Single-Cell Analysis of Signaling Pathways Activated Immediately Downstream of Histamine Receptor Subtypes.Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development.Dynamics of neuroeffector coupling at cardiac sympathetic synapses.cAMPr: A single-wavelength fluorescent sensor for cyclic AMP.Chimeric peptide EP45 as a dual agonist at GLP-1 and NPY2R receptors.PDE4 and mAKAPβ are nodal organizers of β2-ARs nuclear PKA signaling in cardiac myocytes.Using cAMP Sensors to Study Cardiac Nanodomains.Activation of airway epithelial bitter taste receptors by Pseudomonas aeruginosa quinolones modulates calcium, cyclic-AMP, and nitric oxide signaling.Neurotransmitter Switching Coupled to β-Adrenergic Signaling in Sympathetic Neurons in Prehypertensive States.Fluorescent, Bioluminescent, and Optogenetic Approaches to Study Excitable Physiology in the Single Cardiomyocyte.A universal bioluminescence resonance energy transfer sensor design enables high-sensitivity screening of GPCR activation dynamics
P2860
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P2860
Fourth-generation epac-based FRET sensors for cAMP feature exceptional brightness, photostability and dynamic range: characterization of dedicated sensors for FLIM, for ratiometry and with high affinity
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Fourth-generation epac-based F ...... iometry and with high affinity
@ast
Fourth-generation epac-based F ...... iometry and with high affinity
@en
type
label
Fourth-generation epac-based F ...... iometry and with high affinity
@ast
Fourth-generation epac-based F ...... iometry and with high affinity
@en
prefLabel
Fourth-generation epac-based F ...... iometry and with high affinity
@ast
Fourth-generation epac-based F ...... iometry and with high affinity
@en
P2093
P2860
P1433
P1476
Fourth-generation epac-based F ...... iometry and with high affinity
@en
P2093
Aernoud van Batenburg
Daniella Groenewald
Jeffrey Klarenbeek
P2860
P304
P356
10.1371/JOURNAL.PONE.0122513
P407
P577
2015-04-14T00:00:00Z