Antiretroviral nucleosides, deoxynucleotide carrier and mitochondrial DNA: evidence supporting the DNA pol gamma hypothesis. - Wikidata - wikimedia - TriplyDB

Antiretroviral nucleosides, deoxynucleotide carrier and mitochondrial DNA: evidence supporting the DNA pol gamma hypothesis.

Antiretroviral nucleosides, deoxynucleotide carrier and mitochondrial DNA: evidence supporting the DNA pol gamma hypothesis.

http://www.wikidata.org/entity/Q35606742

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Mitochondrial DNA haplogroups influence AIDS progression An analysis of enzyme kinetics data for mitochondrial DNA strand termination by nucleoside reverse transcription inhibitors A mapping of drug space from the viewpoint of small molecule metabolism Caenorhabditis elegans as a Model System for Studying Drug Induced Mitochondrial Toxicity Efavirenz promotes β-secretase expression and increased Aβ1-40,42 via oxidative stress and reduced microglial phagocytosis: implications for HIV associated neurocognitive disorders (HAND).Tenofovir renal toxicity targets mitochondria of renal proximal tubules.Tenofovir-associated bone density loss.Transgenic cardiac-targeted overexpression of human thymidylate kinase Possible mitochondrial dysfunction and its association with antiretroviral therapy use in children perinatally infected with HIV European mitochondrial DNA haplogroups and metabolic changes during antiretroviral therapy in AIDS Clinical Trials Group Study A5142 Polymorphisms in DNA polymerase γ affect the mtDNA stability and the NRTI-induced mitochondrial toxicity in Saccharomyces cerevisiae.Effects of a nucleoside reverse transcriptase inhibitor, stavudine, on glucose disposal and mitochondrial function in muscle of healthy adults Effects of human immunodeficiency virus and metabolic complications on myocardial nutrient metabolism, blood flow, and oxygen consumption: a cross-sectional analysis.Decreased mtDNA, oxidative stress, cardiomyopathy, and death from transgenic cardiac targeted human mutant polymerase gamma.Targeted transgenic overexpression of mitochondrial thymidine kinase (TK2) alters mitochondrial DNA (mtDNA) and mitochondrial polypeptide abundance: transgenic TK2, mtDNA, and antiretrovirals.Abacavir, an anti-HIV-1 drug, targets TDP1-deficient adult T cell leukemia Abnormal newborn screens and acylcarnitines in HIV-exposed and ARV-exposed infants.A novel mechanism of selectivity against AZT by the human mitochondrial DNA polymerase.Identification of fatigue biomarkers in treated and treatment-naive HIV patients: preliminary results.Antiretroviral neurotoxicity The role of mitochondria in pharmacotoxicology: a reevaluation of an old, newly emerging topic.State of the science conference: Initiative to decrease cardiovascular risk and increase quality of care for patients living with HIV/AIDS: executive summary The role of transporters in the toxicity of nucleoside and nucleotide analogs.The role of mitochondrial and plasma membrane nucleoside transporters in drug toxicity.The Molecular and Pharmacological Mechanisms of HIV-Related Neuropathic Pain.Mitochondrial DNA impairment in nucleoside reverse transcriptase inhibitor-associated cardiomyopathy Cardiac-targeted transgenic mutant mitochondrial enzymes: mtDNA defects, antiretroviral toxicity and cardiomyopathy.Pharmacogenetics of nucleoside reverse-transcriptase inhibitor-associated peripheral neuropathy Long-term exposure to AZT, but not d4T, increases endothelial cell oxidative stress and mitochondrial dysfunction.Mitochondrial DNA haplogroups influence lipoatrophy after highly active antiretroviral therapy Long term adverse effects related to nucleoside reverse transcriptase inhibitors: clinical impact of mitochondrial toxicity.The Δ133p53 Isoform Reduces Wtp53-induced Stimulation of DNA Pol γ Activity in the Presence and Absence of D4T Synthesis and Biological Evaluation of 5'-O-Dicarboxylic Fatty Acyl Monoester Derivatives of Anti-HIV Nucleoside Reverse Transcriptase Inhibitors.HAART to heart: highly active antiretroviral therapy and the risk of cardiovascular disease in HIV-infected or exposed children and adults.Cardiovascular involvements in HIV-infected patients.Premature and accelerated aging: HIV or HAART?Virtual screening of acyclovir derivatives as potential antiviral agents: design, synthesis and biological evaluation of new acyclic nucleoside ProTides.Association of Tenofovir Use With Risk of Incident Heart Failure in HIV-Infected Patients.Transgenic mouse model with deficient mitochondrial polymerase exhibits reduced state IV respiration and enhanced cardiac fibrosis.The Role of Transforming Growth Factor Beta-1 in the Progression of HIV/AIDS and Development of Non-AIDS-Defining Fibrotic Disorders.

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P2860

Antiretroviral nucleosides, deoxynucleotide carrier and mitochondrial DNA: evidence supporting the DNA pol gamma hypothesis.

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P2860

The human mitochondrial deoxynucleotide carrier and its role in the toxicity of nucleoside antivirals

Insulin-like growth factor-1 protects ischemic murine myocardium from ischemia/reperfusion associated injury

Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA.

The mitochondrial transporter family (SLC25): physiological and pathological implications

Mitochondrial carrier proteins

Structure-function defects of human mitochondrial DNA polymerase in autosomal dominant progressive external ophthalmoplegia

Effects of (-)-2'-deoxy-3'-thiacytidine (3TC) 5'-triphosphate on human immunodeficiency virus reverse transcriptase and mammalian DNA polymerases alpha, beta, and gamma

Depletion of muscle mitochondrial DNA in AIDS patients with zidovudine-induced myopathy

Mitochondrial ultrastructural and molecular changes induced by zidovudine in rat hearts

Mitochondrial myopathy caused by long-term zidovudine therapy

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