Decreased mtDNA, oxidative stress, cardiomyopathy, and death from transgenic cardiac targeted human mutant polymerase gamma.
about
Mitochondrial DNA replication and disease: insights from DNA polymerase γ mutationsElevated expression of the metabolic regulator receptor-interacting protein 140 results in cardiac hypertrophy and impaired cardiac functionMitochondrial Oxidative Stress, Mitochondrial DNA Damage and Their Role in Age-Related Vascular DysfunctionDNA polymerase γ and disease: what we have learned from yeastOpa1 is required for proper mitochondrial metabolism in early developmentMMS exposure promotes increased MtDNA mutagenesis in the presence of replication-defective disease-associated DNA polymerase γ variantsAssociation of mitochondrial antioxidant enzymes with mitochondrial DNA as integral nucleoid constituentsManganese superoxide dismutase is a mitochondrial fidelity protein that protects Polγ against UV-induced inactivationPathogenicity in POLG syndromes: DNA polymerase gamma pathogenicity prediction server and database.Tenofovir renal toxicity targets mitochondria of renal proximal tubules.Oxidative stress and mitochondrial dysfunction across broad-ranging pathologies: toward mitochondria-targeted clinical strategies.Transgenic cardiac-targeted overexpression of human thymidylate kinaseDNA polymerases as potential therapeutic targets for cancers deficient in the DNA mismatch repair proteins MSH2 or MLH1Mitochondrial genome maintenance in health and disease.mip1 containing mutations associated with mitochondrial disease causes mutagenesis and depletion of mtDNA in Saccharomyces cerevisiaeThe role of PGC-1 coactivators in aging skeletal muscle and heart.Tenofovir renal proximal tubular toxicity is regulated by OAT1 and MRP4 transportersAging and HIV/AIDS: pathogenetic role of therapeutic side effectsDefects of mitochondrial DNA replication.Human immunodeficiency virus/acquired immunodeficiency syndrome and infertility: emerging problems in the era of highly active antiretrovirals.Defects in mitochondrial DNA replication and human diseaseInherited mitochondrial diseases of DNA replicationEndonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function.Maintaining ancient organelles: mitochondrial biogenesis and maturation.Mitochondrial Diseases Part II: Mouse models of OXPHOS deficiencies caused by defects in regulatory factors and other components required for mitochondrial function.Sensory ataxic neuropathy with dysarthria/dysphagia and ophthalmoplegia (SANDO). Two case reports.Effect of the Y955C mutation on mitochondrial DNA polymerase nucleotide incorporation efficiency and fidelity.Therapeutic Targeting of the Mitochondria Initiates Excessive Superoxide Production and Mitochondrial Depolarization Causing Decreased mtDNA IntegrityThe DNA polymerase gamma Y955C disease variant associated with PEO and parkinsonism mediates the incorporation and translesion synthesis opposite 7,8-dihydro-8-oxo-2'-deoxyguanosine.Zebrafish lacking functional DNA polymerase gamma survive to juvenile stage, despite rapid and sustained mitochondrial DNA depletion, altered energetics and growthTrace amounts of 8-oxo-dGTP in mitochondrial dNTP pools reduce DNA polymerase gamma replication fidelity.Mitochondrial polymerase gamma dysfunction and aging cause cardiac nuclear DNA methylation changes.The exonuclease activity of the yeast mitochondrial DNA polymerase γ suppresses mitochondrial DNA deletions between short direct repeats in Saccharomyces cerevisiaeThe role of transporters in the toxicity of nucleoside and nucleotide analogs.Clinical and molecular features of POLG-related mitochondrial disease.Vascular aging: chronic oxidative stress and impairment of redox signaling-consequences for vascular homeostasis and disease.Thymidine kinase and mtDNA depletion in human cardiomyopathy: epigenetic and translational evidence for energy starvation.Mouse models of mitochondrial DNA defects and their relevance for human disease.Mouse models of oxidative phosphorylation defects: powerful tools to study the pathobiology of mitochondrial diseases.Murine cardiac mtDNA: effects of transgenic manipulation of nucleoside phosphorylation.
P2860
Q24612561-3374E0CB-026B-4727-9325-D25AB6AA0AEFQ24621162-C5172EC8-27B0-42E6-859C-053BBF95D4F5Q26799985-C6B1D00E-84B0-4D92-BED5-DD2680E8D684Q26825324-C79FC188-258B-4B68-9E4D-0D7A5F3F311BQ27334237-3CAB8090-6C18-4FB5-9EEF-E38FEFBF1496Q28544021-DD5D8DAE-D700-45B6-A0F2-DF0450CBB1E3Q28581179-C9242876-0E8D-46F9-AD28-3AFD75D74970Q28594641-EE68D6A8-3EA6-45FF-86CE-3303A987BBBCQ30401750-420AE39A-3ABF-4042-920D-8E52F2405B31Q33416391-B227AB97-9CB1-440A-8635-58E05A5E3DC7Q33625254-972CBEBE-38D6-447A-8B2B-2B20B3293725Q33690295-90C3236B-976D-4B6D-B848-D7F3DD3DF624Q33754229-394C7955-DBC5-4D5E-938E-B487FD6FD99BQ33821051-7C92E057-E051-4251-868B-A3CB5A10B31CQ33832860-3A9D89C7-07FB-4DD4-AEAC-E9EE55C12746Q33840188-62F7E470-C0AA-470D-83B1-E125A180E3EBQ33845879-86986B76-2F96-4782-B836-DE143C0A4322Q34089694-5D9C8CE2-73E5-4114-A3E7-94B1A771956DQ34098312-85FA62AB-9D16-488E-B4B9-38D15D2B312DQ34196934-C8C950B3-35B7-4264-855C-51F2B015C60BQ34241192-FD808498-80E0-4634-A8D3-E33C42C9E243Q34692482-1390386B-EA4E-4C09-8B34-2A26C3B38AD8Q35294331-97EA5FBB-005D-4FFD-8E74-65FF3BFEA2C7Q35645509-2749CBB9-6C56-4197-939D-344CFFEA48A7Q35660977-25B9C7A8-0D03-4688-944F-909185E7E234Q35816846-E3A27BFD-7C9C-4673-8C54-A49DFA71E8ABQ36053570-6398E6FA-D912-4DBB-AE63-79417890E6E6Q36234714-717BAEE8-C085-4380-A04D-840D508A83E7Q36253589-0A864ED2-F9AA-4DC8-870C-3043D12D8E96Q36337679-E95C0952-0807-4521-8DC0-06DF6D352414Q36633152-7A0CCB74-9B36-4C29-971A-56D7B1AB4640Q36775694-F6ED927A-06C2-4CBD-9060-BCFDF06F7D04Q36878648-C10EF9FD-DBBB-4932-8FD7-929A75B1647EQ36921993-E18FDACE-8046-4448-B006-133154F3CA34Q36932851-4E4A6D58-6CD4-4E20-9272-9024C14110B1Q37030271-997A7883-0C02-4505-84D6-D6D10F9120A2Q37054681-873E0AFC-2F41-4AF3-BDE4-051786AAF2E7Q37087221-4D1B4F15-1C46-4220-B04B-711E700A93DFQ37120797-ED7B2E76-DCC3-4FFB-AB10-B6A815F075B6Q37199813-C8A17108-11FD-497D-B727-549DC22AD1A7
P2860
Decreased mtDNA, oxidative stress, cardiomyopathy, and death from transgenic cardiac targeted human mutant polymerase gamma.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Decreased mtDNA, oxidative str ...... human mutant polymerase gamma.
@ast
Decreased mtDNA, oxidative str ...... human mutant polymerase gamma.
@en
type
label
Decreased mtDNA, oxidative str ...... human mutant polymerase gamma.
@ast
Decreased mtDNA, oxidative str ...... human mutant polymerase gamma.
@en
prefLabel
Decreased mtDNA, oxidative str ...... human mutant polymerase gamma.
@ast
Decreased mtDNA, oxidative str ...... human mutant polymerase gamma.
@en
P2093
P2860
P1476
Decreased mtDNA, oxidative str ...... human mutant polymerase gamma
@en
P2093
Brian J Day
Chad P Haase
Elgin C Green
Erin S Keebaugh
James J Kohler
Jeffrey Steltzer
Nina Tioleco
Robert Long
Robert Santoianni
Rodney Russ
P2860
P2888
P304
P356
10.1038/LABINVEST.3700523
P577
2006-02-19T00:00:00Z