Crkl deficiency disrupts Fgf8 signaling in a mouse model of 22q11 deletion syndromes.
about
MAP'ing CNS development and cognition: an ERKsome processReceptor specificity of the fibroblast growth factor family. The complete mammalian FGF familyFibroblast growth factor signaling in skeletal development and diseaseThe adaptor protein Crk in immune responseOf mice and men: molecular genetics of congenital heart diseaseConnecting teratogen-induced congenital heart defects to neural crest cells and their effect on cardiac functionThe neural crest in cardiac congenital anomaliesGenetic insights into the mechanisms of Fgf signalingReceptor tyrosine kinase signaling: regulating neural crest development one phosphate at a timeDefective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defectsMouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest developmentRequired, tissue-specific roles for Fgf8 in outflow tract formation and remodelingFgf8 expression in the Tbx1 domain causes skeletal abnormalities and modifies the aortic arch but not the outflow tract phenotype of Tbx1 mutantsEarly thyroid development requires a Tbx1-Fgf8 pathwayEvolutionary and developmental origins of the cardiac neural crest: building a divided outflow tractA pre-metazoan origin of the CRK gene family and co-opted signaling networkManteia, a predictive data mining system for vertebrate genes and its applications to human genetic diseasesFrs2α and Shp2 signal independently of Gab to mediate FGF signaling in lens development.Decreased levels of embryonic retinoic acid synthesis accelerate recovery from arterial growth delay in a mouse model of DiGeorge syndromeNovel TBX1 loss-of-function mutation causes isolated conotruncal heart defects in Chinese patients without 22q11.2 deletion.Trigenic neural crest-restricted Smad7 over-expression results in congenital craniofacial and cardiovascular defects.Phenotypic impact of genomic structural variation: insights from and for human disease.Thioredoxin Reductase 2 (TXNRD2) mutation associated with familial glucocorticoid deficiency (FGD).The Fibroblast Growth Factor signaling pathwayGenetic Drivers of Kidney Defects in the DiGeorge Syndrome.A mouse splice-site mutant and individuals with atypical chromosome 22q11.2 deletions demonstrate the crucial role for crkl in craniofacial and pharyngeal development.Heparan sulfate expression in the neural crest is essential for mouse cardiogenesis.Conditional deletion of focal adhesion kinase leads to defects in ventricular septation and outflow tract alignmentFgfr1 regulates development through the combinatorial use of signaling proteins.Histone Modifier Genes Alter Conotruncal Heart Phenotypes in 22q11.2 Deletion Syndrome.DGCR6 at the proximal part of the DiGeorge critical region is involved in conotruncal heart defects.Model systems for the study of heart development and disease. Cardiac neural crest and conotruncal malformationsRetinoic acid controls heart anteroposterior patterning by down-regulating Isl1 through the Fgf8 pathway.No evidence for parental imprinting of mouse 22q11 gene orthologsPbx1 functions in distinct regulatory networks to pattern the great arteries and cardiac outflow tract.Structural and functional basis of a role for CRKL in a fibroblast growth factor 8-induced feed-forward loop.Genetic modifiers of the physical malformations in velo-cardio-facial syndrome/DiGeorge syndrome.Protein tyrosine phosphatase activity in the neural crest is essential for normal heart and skull development.Focal adhesion kinase is required for neural crest cell morphogenesis during mouse cardiovascular development.Understanding the role of Tbx1 as a candidate gene for 22q11.2 deletion syndrome
P2860
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P2860
Crkl deficiency disrupts Fgf8 signaling in a mouse model of 22q11 deletion syndromes.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Crkl deficiency disrupts Fgf8 signaling in a mouse model of 22q11 deletion syndromes.
@ast
Crkl deficiency disrupts Fgf8 signaling in a mouse model of 22q11 deletion syndromes.
@en
type
label
Crkl deficiency disrupts Fgf8 signaling in a mouse model of 22q11 deletion syndromes.
@ast
Crkl deficiency disrupts Fgf8 signaling in a mouse model of 22q11 deletion syndromes.
@en
prefLabel
Crkl deficiency disrupts Fgf8 signaling in a mouse model of 22q11 deletion syndromes.
@ast
Crkl deficiency disrupts Fgf8 signaling in a mouse model of 22q11 deletion syndromes.
@en
P2093
P2860
P921
P1433
P1476
Crkl deficiency disrupts Fgf8 signaling in a mouse model of 22q11 deletion syndromes
@en
P2093
Akira Imamoto
Amy Talbot
Anne M Moon
Deborah L Guris
Ji-heui Seo
Leiming Li
P2860
P356
10.1016/J.DEVCEL.2005.12.003
P407
P577
2006-01-01T00:00:00Z