HIV-susceptible transgenic rats allow rapid preclinical testing of antiviral compounds targeting virus entry or reverse transcription
about
HIV-associated neurocognitive disorder--pathogenesis and prospects for treatmentMolecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor NefSAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.Can the new humanized mouse model give HIV research a boostProteomic modeling for HIV-1 infected microglia-astrocyte crosstalk.Long-lasting enfuvirtide carrier pentasaccharide conjugates with potent anti-human immunodeficiency virus type 1 activity.High natural permissivity of primary rabbit cells for HIV-1, with a virion infectivity defect in macrophages as the final replication barrier.Rodent models for HIV-associated neurocognitive disorders.Primary T-cells from human CD4/CCR5-transgenic rats support all early steps of HIV-1 replication including integration, but display impaired viral gene expression.Summary of presentations at the NIH/NIAID New Humanized Rodent Models 2007 Workshop.Aqueous extracts from peppermint, sage and lemon balm leaves display potent anti-HIV-1 activity by increasing the virion density.Relief of preintegration inhibition and characterization of additional blocks for HIV replication in primary mouse T cells.Mouse T-cells restrict replication of human immunodeficiency virus at the level of integration.Antibody and antiretroviral preexposure prophylaxis prevent cervicovaginal HIV-1 infection in a transgenic mouse model.Murine models for HIV vaccination and challenge.Expression of Human CD4 and chemokine receptors in cotton rat cells confers permissiveness for productive HIV infection.Pharmacovirological impact of an integrase inhibitor on human immunodeficiency virus type 1 cDNA species in vivoImpact of raltegravir on HIV-1 RNA and DNA forms following initiation of antiretroviral therapy in treatment-naive patients.HIV-1 susceptibility of transgenic rat-derived primary macrophage/T cells and a T cell line that express human receptors, CyclinT1 and CRM1 genes.Endogenous CD317/Tetherin limits replication of HIV-1 and murine leukemia virus in rodent cells and is resistant to antagonists from primate viruses.HIV-associated synaptic degeneration.Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells.Human cyclin T1 expression ameliorates a T-cell-specific transcriptional limitation for HIV in transgenic rats, but is not sufficient for a spreading infection of prototypic R5 HIV-1 strains ex vivo.
P2860
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P2860
HIV-susceptible transgenic rats allow rapid preclinical testing of antiviral compounds targeting virus entry or reverse transcription
description
2007 nî lūn-bûn
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2007年の論文
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2007年論文
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2007年論文
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2007年論文
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2007年論文
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2007年論文
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2007年论文
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2007年论文
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2007年论文
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name
HIV-susceptible transgenic rat ...... entry or reverse transcription
@ast
HIV-susceptible transgenic rat ...... entry or reverse transcription
@en
type
label
HIV-susceptible transgenic rat ...... entry or reverse transcription
@ast
HIV-susceptible transgenic rat ...... entry or reverse transcription
@en
prefLabel
HIV-susceptible transgenic rat ...... entry or reverse transcription
@ast
HIV-susceptible transgenic rat ...... entry or reverse transcription
@en
P2860
P356
P1476
HIV-susceptible transgenic rat ...... entry or reverse transcription
@en
P2093
Ina Allespach
Oliver T Keppler
P2860
P304
P356
10.1073/PNAS.0607414104
P407
P577
2007-01-05T00:00:00Z