Critical Molecular Determinants of α7 Nicotinic Acetylcholine Receptor Allosteric Activation: SEPARATION OF DIRECT ALLOSTERIC ACTIVATION AND POSITIVE ALLOSTERIC MODULATION.
about
Persistent activation of α7 nicotinic ACh receptors associated with stable induction of different desensitized states.The development of novel polypharmacological agents targeting the multiple binding sites of nicotinic acetylcholine receptors.Leveraging allostery to improve G protein-coupled receptor (GPCR)-directed therapeutics: cannabinoid receptor 1 as discovery target.Orthosteric and allosteric potentiation of heteromeric neuronal nicotinic acetylcholine receptors.Nicotinic acetylcholine receptors at the single-channel level.The α7 nicotinic receptor dual allosteric agonist and positive allosteric modulator GAT107 reverses nociception in mouse models of inflammatory and neuropathic pain.The interaction between alpha 7 nicotinic acetylcholine receptor and nuclear peroxisome proliferator-activated receptor-α represents a new antinociceptive signaling pathway in mice.New Insights on Neuronal Nicotinic Acetylcholine Receptors as Targets for Pain and Inflammation: A Focus on α7 nAChRs.The current agonists and positive allosteric modulators of α7 nAChR for CNS indications in clinical trials.Molecular function of α7 nicotinic receptors as drug targets.
P2860
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P2860
Critical Molecular Determinants of α7 Nicotinic Acetylcholine Receptor Allosteric Activation: SEPARATION OF DIRECT ALLOSTERIC ACTIVATION AND POSITIVE ALLOSTERIC MODULATION.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Critical Molecular Determinant ...... OSITIVE ALLOSTERIC MODULATION.
@ast
Critical Molecular Determinant ...... OSITIVE ALLOSTERIC MODULATION.
@en
type
label
Critical Molecular Determinant ...... OSITIVE ALLOSTERIC MODULATION.
@ast
Critical Molecular Determinant ...... OSITIVE ALLOSTERIC MODULATION.
@en
prefLabel
Critical Molecular Determinant ...... OSITIVE ALLOSTERIC MODULATION.
@ast
Critical Molecular Determinant ...... OSITIVE ALLOSTERIC MODULATION.
@en
P2093
P2860
P356
P1476
Critical Molecular Determinant ...... OSITIVE ALLOSTERIC MODULATION.
@en
P2093
Abhijit R Kulkarni
Clare Stokes
Ganesh A Thakur
Khan Manther
Nicole A Horenstein
Roger L Papke
P2860
P304
P356
10.1074/JBC.M115.692392
P407
P577
2016-01-07T00:00:00Z