The discovery of ezetimibe: a view from outside the receptor.
about
Membrane topology of human NPC1L1, a key protein in enterohepatic cholesterol absorptionMolecular processes that handle -- and mishandle -- dietary lipidsFomiroid A, a novel compound from the mushroom Fomitopsis nigra, inhibits NPC1L1-mediated cholesterol uptake via a mode of action distinct from that of ezetimibeThe target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)Effect of ezetimibe on incretin secretion in response to the intestinal absorption of a mixed meal.Therapeutics for filovirus infection: traditional approaches and progress towards in silico drug design.Population pharmacodynamic analysis of LDL-cholesterol lowering effects by statins and co-medications based on electronic medical records.Ezetimibe: its novel effects on the prevention and the treatment of cholesterol gallstones and nonalcoholic Fatty liver diseaseEnantioselective cis-β-lactam synthesis by intramolecular C-H functionalization from enoldiazoacetamides and derivative donor-acceptor cyclopropenes.Fluorine in medicinal chemistry.Protein mediators of sterol transport across intestinal brush border membrane.Simvastatin plus ezetimibe: combination therapy for the management of dyslipidaemia.Comparative study on solid self-nanoemulsifying drug delivery and solid dispersion system for enhanced solubility and bioavailability of ezetimibe.Forward in reverse: how reverse genetics complements chemical genetics.Cholesterol absorption inhibitors as a therapeutic option for hypercholesterolaemia.Update on patented cholesterol absorption inhibitors.Systematizing serendipity for cardiovascular drug discovery.Transporters as drug targets: discovery and development of NPC1L1 inhibitors.Allenyl-β-lactams: versatile scaffolds for the synthesis of heterocycles.How can high-throughput screening deliver drugs to treat atherosclerosis?A case study of single-pill combination therapy: the ezetimibe/simvastatin combination for treatment of hyperlipidemia.Inhibition of cholesterol absorption: targeting the intestine.Introduction of fluorine and fluorine-containing functional groups.Intestinal nuclear receptors in HDL cholesterol metabolism.Recent advances in fluorination techniques and their anticipated impact on drug metabolism and toxicity.Ezetimibe plus simvastatin for the treatment of hypercholesterolemia.Zebrafish as tools for drug discovery.Ezetimibe interferes with cholesterol trafficking from the plasma membrane to the endoplasmic reticulum in CaCo-2 cells.Efficacy of ezetimibe is not related to NPC1L1 gene polymorphisms in a pilot study of Chilean hypercholesterolemic subjects.Gold-catalyzed heterocyclizations in alkynyl- and allenyl-β-lactams.Rh-Catalyzed reductive Mannich-type reaction and its application towards the synthesis of (±)-ezetimibe.Targeted Fluoro Positioning for the Discovery of a Potent and Highly Selective Matrix Metalloproteinase InhibitorMultistep phase-switch synthesis by using liquid-liquid partitioning of boronic acids: productive tags with an expanded repertoire of compatible reactions.Asymmetric synthesis of trans-β-lactams by a Kinugasa reaction on water.Fluorine bonding enhances the energetics of protein-lipid binding in the gas phase.Palladium-catalyzed highly regioselective hydroaminocarbonylation of aromatic alkenes to branched amides.Asymmetric Synthesis of β-Lactams through Copper-Catalyzed Alkyne-Nitrone Coupling with a Prolinol-Phosphine Chiral Ligand.Identification, synthesis and characterization of process related desfluoro impurity of ezetimibe and HPLC method validations.Palladium-catalyzed hydroaminocarbonylation of alkenes with amines: a strategy to overcome the basicity barrier imparted by aliphatic amines.Ru-catalyzed asymmetric hydrogenation of δ-keto Weinreb amides: enantioselective synthesis of (+)-Centrolobine.
P2860
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P2860
The discovery of ezetimibe: a view from outside the receptor.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
The discovery of ezetimibe: a view from outside the receptor.
@ast
The discovery of ezetimibe: a view from outside the receptor.
@en
type
label
The discovery of ezetimibe: a view from outside the receptor.
@ast
The discovery of ezetimibe: a view from outside the receptor.
@en
prefLabel
The discovery of ezetimibe: a view from outside the receptor.
@ast
The discovery of ezetimibe: a view from outside the receptor.
@en
P356
P1476
The discovery of ezetimibe: a view from outside the receptor.
@en
P2093
John W Clader
P356
10.1021/JM030283G
P407
P577
2004-01-01T00:00:00Z