Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice.
about
Propagation of tau pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies.Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo.Tau pathology spread in PS19 tau transgenic mice following locus coeruleus (LC) injections of synthetic tau fibrils is determined by the LC's afferent and efferent connectionsImmunotherapeutic Approaches Targeting Amyloid-β, α-Synuclein, and Tau for the Treatment of Neurodegenerative Disorders.Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo.The evolutionary scope and neurological disease linkage of yeast-prion-like proteins in humans.Sustained synchronized neuronal network activity in a human astrocyte co-culture system.Unique pathological tau conformers from Alzheimer's brains transmit tau pathology in nontransgenic mice.The role of exosomes in the pathogenesis of Alzheimer' disease.Prions and Protein Assemblies that Convey Biological Information in Health and Disease.Pimozide reduces toxic forms of tau in TauC3 mice via 5' adenosine monophosphate-activated protein kinase-mediated autophagy.Interactions between Microtubule-Associated Protein Tau (MAPT) and Small Molecules.The Prion-Like Behavior of Assembled Tau in Transgenic Mice.The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition.Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes.What is the evidence that tau pathology spreads through prion-like propagation?Distinct differences in prion-like seeding and aggregation between tau protein variants provide mechanistic insights into tauopathies.Tau-mediated Neurodegeneration and Potential Implications in Diagnosis and Treatment of Alzheimer's Disease.Widespread brain tau and its association with ageing, Braak stage and Alzheimer's dementia.Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry.The use of mouse models to study cell-to-cell transmission of pathological tau.Widespread tau seeding activity at early Braak stages.Applications of the real-time quaking-induced conversion assay in diagnosis, prion strain-typing, drug pre-screening and other amyloidopathies.Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain.Elevated medial temporal lobe and pervasive brain tau-PET signal in normal participants.Tau Pathology in Parkinson's Disease
P2860
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P2860
Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Templated misfolding of Tau by ...... tcomes in Tau transgenic mice.
@ast
Templated misfolding of Tau by ...... tcomes in Tau transgenic mice.
@en
type
label
Templated misfolding of Tau by ...... tcomes in Tau transgenic mice.
@ast
Templated misfolding of Tau by ...... tcomes in Tau transgenic mice.
@en
prefLabel
Templated misfolding of Tau by ...... tcomes in Tau transgenic mice.
@ast
Templated misfolding of Tau by ...... tcomes in Tau transgenic mice.
@en
P2093
P2860
P50
P1476
Templated misfolding of Tau by ...... tcomes in Tau transgenic mice.
@en
P2093
Agnès Villers
Arjan Buist
Bruno Vasconcelos
Cindy Casteels
Dick Terwel
Diederik Moechars
Eve Peeraer
Guy Bormans
Jean-Nöel Octave
Laurence Ris
P2860
P2888
P304
P356
10.1007/S00401-015-1413-4
P577
2015-04-11T00:00:00Z