Anti-tumour activity of afatinib, an irreversible ErbB family blocker, in human pancreatic tumour cells
about
Pancreatic Cancer from Molecular Pathways to Treatment OpinionPancreatic cancer from bench to bedside: molecular pathways and treatment optionsState of the art biological therapies in pancreatic cancerAfatinib, an Irreversible EGFR Family Inhibitor, Shows Activity Toward Pancreatic Cancer Cells, Alone and in Combination with Radiotherapy, Independent of KRAS Status.A comprehensive review of the preclinical efficacy profile of the ErbB family blocker afatinib in cancer.Synergistic effects of various Her inhibitors in combination with IGF-1R, C-MET and Src targeting agents in breast cancer cell linesTreatment with a combination of the ErbB (HER) family blocker afatinib and the IGF-IR inhibitor, NVP-AEW541 induces synergistic growth inhibition of human pancreatic cancer cells.Human pancreatic cancer stem cells are sensitive to dual inhibition of IGF-IR and ErbB receptors.Acquired resistance of pancreatic cancer cells to treatment with gemcitabine and HER-inhibitors is accompanied by increased sensitivity to STAT3 inhibition.In vitro and in vivo efficacy of afatinib as a single agent or in combination with gemcitabine for the treatment of nasopharyngeal carcinoma.Impact of the putative cancer stem cell markers and growth factor receptor expression on the sensitivity of ovarian cancer cells to treatment with various forms of small molecule tyrosine kinase inhibitors and cytotoxic drugs.Ethacrynic acid improves the antitumor effects of irreversible epidermal growth factor receptor tyrosine kinase inhibitors in breast cancer.Quinazoline derivatives as potential anticancer agents: a patent review (2007 - 2010).Investigational therapies targeting the ErbB (EGFR, HER2, HER3, HER4) family in GI cancers.The Potential of panHER Inhibition in Cancer.Antibiofilm activity and mode of action of DMSO alone and its combination with afatinib against Gram-negative pathogens.Functionalized gold nanoparticles improve afatinib delivery into cancer cells.Metabolic flux-driven sialylation alters internalization, recycling, and drug sensitivity of the epidermal growth factor receptor (EGFR) in SW1990 pancreatic cancer cells.Targeted dianthin is a powerful toxin to treat pancreatic carcinoma when applied in combination with the glycosylated triterpene SO1861.The RNA/DNA-binding protein PSF relocates to cell membrane and contributes cells' sensitivity to antitumor drug, doxorubicin.Development of novel monoclonal antibodies against CD109 overexpressed in human pancreatic cancer.
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P2860
Anti-tumour activity of afatinib, an irreversible ErbB family blocker, in human pancreatic tumour cells
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Anti-tumour activity of afatin ...... human pancreatic tumour cells
@ast
Anti-tumour activity of afatin ...... human pancreatic tumour cells
@en
type
label
Anti-tumour activity of afatin ...... human pancreatic tumour cells
@ast
Anti-tumour activity of afatin ...... human pancreatic tumour cells
@en
prefLabel
Anti-tumour activity of afatin ...... human pancreatic tumour cells
@ast
Anti-tumour activity of afatin ...... human pancreatic tumour cells
@en
P2093
P2860
P356
P1476
Anti-tumour activity of afatin ...... human pancreatic tumour cells
@en
P2093
A G Dalgleish
A M Seddon
D Mackintosh
U Guertler
P2860
P2888
P304
P356
10.1038/BJC.2011.396
P407
P577
2011-10-04T00:00:00Z