APL-1, a Caenorhabditis elegans protein related to the human beta-amyloid precursor protein, is essential for viability. - Wikidata - wikimedia - TriplyDB

APL-1, a Caenorhabditis elegans protein related to the human beta-amyloid precursor protein, is essential for viability.

APL-1, a Caenorhabditis elegans protein related to the human beta-amyloid precursor protein, is essential for viability.

http://www.wikidata.org/entity/Q35629330

about

Origins of amyloid-β CASY-1, an ortholog of calsyntenins/alcadeins, is essential for learning in Caenorhabditis elegans Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis Neural stem/progenitor cells in Alzheimer's disease Using C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseases Caenorhabditis elegans as a model organism to study APP function Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease The Caenorhabditis elegans epidermis as a model skin. II: differentiation and physiological roles The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes The Amyloid Precursor Protein Controls PIKfyve Function Structural Characterization of the E2 Domain of APL-1, a Caenorhabditis elegans Homolog of Human Amyloid Precursor Protein, and Its Heparin Binding Site Crystal structure of amyloid precursor-like protein 1 and heparin complex suggests a dual role of heparin in E2 dimerization Quantification of copper binding to amyloid precursor protein domain 2 and its Caenorhabditis elegans ortholog. Implications for biological function Intracellular trafficking and synaptic function of APL-1 in Caenorhabditis elegans Large-scale microfluidics providing high-resolution and high-throughput screening of Caenorhabditis elegans poly-glutamine aggregation model.Animal models for Alzheimer's disease and frontotemporal dementia: a perspective Amyloid precursor protein trafficking, processing, and function Alzheimer disease models and human neuropathology: similarities and differences Beta-secretase: structure, function, and evolution.Regulation of neuronal APL-1 expression by cholesterol starvation.Knockdown of amyloid precursor protein in zebrafish causes defects in motor axon outgrowth.Deletion of the amyloid precursor-like protein 2 (APLP2) does not affect hippocampal neuron morphology or function.Advances with RNA interference in Alzheimer's disease research.Neurogenin 2 mediates amyloid-β precursor protein-stimulated neurogenesis.APP as a Protective Factor in Acute Neuronal Insults.A single tyrosine residue in the amyloid precursor protein intracellular domain is essential for developmental function.A cocoa peptide protects Caenorhabditis elegans from oxidative stress and β-amyloid peptide toxicity.Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery.Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis.APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP.The roles of amyloid precursor protein (APP) in neurogenesis: Implications to pathogenesis and therapy of Alzheimer disease.APL-1, the Alzheimer's Amyloid precursor protein in Caenorhabditis elegans, modulates multiple metabolic pathways throughout development.Alzheimer's disease models and functional genomics-How many needles are there in the haystack?The secreted Alzheimer-related amyloid precursor protein fragment has an essential role in C. elegans Modeling Alzheimer's disease: from past to future Role of cystatin C in amyloid precursor protein-induced proliferation of neural stem/progenitor cells.Pan-neuronal expression of APL-1, an APP-related protein, disrupts olfactory, gustatory, and touch plasticity in Caenorhabditis elegans Alzheimer-related protein APL-1 modulates lifespan through heterochronic gene regulation in Caenorhabditis elegans.Neuronal aging: learning from C. elegans

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APL-1, a Caenorhabditis elegans protein related to the human beta-amyloid precursor protein, is essential for viability.

http://www.wikidata.org/entity/Q35629330

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Gregory O'Connor

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Isabelle Daigle

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Jason Lieberthal

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Lawrence Ha

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Mindy Markowitz

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The genetics of Caenorhabditis elegans

The amyloid-beta precursor protein: integrating structure with biological function

Amyloid plaque core protein in Alzheimer disease and Down syndrome

Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I

Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members

Amyloid precursor protein interacts with notch receptors

Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

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1971-1976

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17267616

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Caenorhabditis elegans

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