Motor deficits and hyperactivity in Dyt1 knockdown mice.
about
TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeletonAbnormal striatal dopaminergic neurotransmission during rest and task production in spasmodic dysphonia.Increased c-fos expression in the central nucleus of the amygdala and enhancement of cued fear memory in Dyt1 DeltaGAG knock-in miceEarlier onset of motor deficits in mice with double mutations in Dyt1 and Sgce.A novel conditional knock-in approach defines molecular and circuit effects of the DYT1 dystonia mutation.Tor1a+/- mice develop dystonia-like movements via a striatal dopaminergic dysregulation triggered by peripheral nerve injury.Cholinergic dysregulation produced by selective inactivation of the dystonia-associated protein torsinA.Cell-autonomous alteration of dopaminergic transmission by wild type and mutant (DeltaE) TorsinA in transgenic mice.Convergent evidence for abnormal striatal synaptic plasticity in dystonia.Altered dendritic morphology of Purkinje cells in Dyt1 ΔGAG knock-in and purkinje cell-specific Dyt1 conditional knockout mice.Motor deficits and decreased striatal dopamine receptor 2 binding activity in the striatum-specific Dyt1 conditional knockout miceAbnormal nuclear envelope in the cerebellar Purkinje cells and impaired motor learning in DYT11 myoclonus-dystonia mouse modelsDysregulation of striatal dopamine release in a mouse model of dystonia.Characterization of Atp1a3 mutant mice as a model of rapid-onset dystonia with parkinsonism.4-Phenylbutyrate attenuates the ER stress response and cyclic AMP accumulation in DYT1 dystonia cell models.Modulation of the basal ganglia dopaminergic system in a transgenic mouse exhibiting dystonia-like features.Mutant torsinA interferes with protein processing through the secretory pathway in DYT1 dystonia cells.Untethering the nuclear envelope and cytoskeleton: biologically distinct dystonias arising from a common cellular dysfunctionPre-synaptic release deficits in a DYT1 dystonia mouse model.Abnormal striatal and thalamic dopamine neurotransmission: Genotype-related features of dystonia.Commentary: Dopaminergic dysfunction in DYT1 dystonia.Behavioral and electrophysiological characterization of Dyt1 heterozygous knockout mice.Animal models of dystonia: Lessons from a mutant rat.An anticholinergic reverses motor control and corticostriatal LTD deficits in Dyt1 ΔGAG knock-in mice.Abnormal nuclear envelopes in the striatum and motor deficits in DYT11 myoclonus-dystonia mouse modelsIntragenic Cis and Trans modification of genetic susceptibility in DYT1 torsion dystoniaImproved motor performance in Dyt1 ΔGAG heterozygous knock-in mice by cerebellar Purkinje-cell specific Dyt1 conditional knocking-outMouse models of neurodevelopmental disease of the basal ganglia and associated circuits.Functional analysis of dopaminergic systems in a DYT1 knock-in mouse model of dystonia.Abnormal motor function and dopamine neurotransmission in DYT1 DeltaGAG transgenic mice.Identifying the genetic components underlying the pathophysiology of movement disorders.DYT1 dystonia increases risk taking in humansEngineering animal models of dystoniaCortically evoked long-lasting inhibition of pallidal neurons in a transgenic mouse model of dystoniaStriatal dopaminergic dysfunction at rest and during task performance in writer's cramp.Molecular pathways in dystonia.Function of dopamine transporter is compromised in DYT1 transgenic animal model in vivoElectromyographic evidence in support of a knock-in mouse model of DYT1 Dystonia.Neurogenesis and neuronal migration in the forebrain of the TorsinA knockout mouse embryo.Histamine N-methyltransferase regulates aggression and the sleep-wake cycle.
P2860
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P2860
Motor deficits and hyperactivity in Dyt1 knockdown mice.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Motor deficits and hyperactivity in Dyt1 knockdown mice.
@ast
Motor deficits and hyperactivity in Dyt1 knockdown mice.
@en
type
label
Motor deficits and hyperactivity in Dyt1 knockdown mice.
@ast
Motor deficits and hyperactivity in Dyt1 knockdown mice.
@en
prefLabel
Motor deficits and hyperactivity in Dyt1 knockdown mice.
@ast
Motor deficits and hyperactivity in Dyt1 knockdown mice.
@en
P2860
P1476
Motor deficits and hyperactivity in Dyt1 knockdown mice
@en
P2093
Fumiaki Yokoi
Mai T Dang
P2860
P304
P356
10.1016/J.NEURES.2006.09.005
P577
2006-10-13T00:00:00Z