Cilia-like structures and polycystin-1 in osteoblasts/osteocytes and associated abnormalities in skeletogenesis and Runx2 expression. - Wikidata - wikimedia - TriplyDB

Cilia-like structures and polycystin-1 in osteoblasts/osteocytes and associated abnormalities in skeletogenesis and Runx2 expression.

Cilia-like structures and polycystin-1 in osteoblasts/osteocytes and associated abnormalities in skeletogenesis and Runx2 expression.

http://www.wikidata.org/entity/Q35634081

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The amazing osteocyte Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells Recent progress in osteocyte research Cilia/Ift protein and motor -related bone diseases and mouse models Physiological mechanisms and therapeutic potential of bone mechanosensing.Kif3a deficiency reverses the skeletal abnormalities in Pkd1 deficient mice by restoring the balance between osteogenesis and adipogenesis Mechanosensing by the primary cilium: deletion of Kif3A reduces bone formation due to loading Osteoblast-specific deletion of Pkd2 leads to low-turnover osteopenia and reduced bone marrow adiposity Biomechanics and mechanobiology of trabecular bone: a review.Bicc1 is a genetic determinant of osteoblastogenesis and bone mineral density.Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism.Real-time vascular mechanosensation through ex vivo artery perfusion.Conditional disruption of Pkd1 in osteoblasts results in osteopenia due to direct impairment of bone formation.Sensing a sensor: identifying the mechanosensory function of primary cilia Primary cilia are highly oriented with respect to collagen direction and long axis of extensor tendon Role of TGF-β in a mouse model of high turnover renal osteodystrophy.Role of the polycytin-primary cilia complex in bone development and mechanosensing Mechanical Signals As a Non-Invasive Means to Influence Mesenchymal Stem Cell Fate, Promoting Bone and Suppressing the Fat Phenotype Extracellular matrix mineralization promotes E11/gp38 glycoprotein expression and drives osteocytic differentiation Mechanotransduction in the renal tubule Conditional mesenchymal disruption of pkd1 results in osteopenia and polycystic kidney disease.Hypertension in Autosomal Dominant Polycystic Kidney Disease: A Clinical and Basic Science Perspective Gain-of-function mutations in TRPV4 cause autosomal dominant brachyolmia Cilia involvement in patterning and maintenance of the skeleton Function and regulation of primary cilia and intraflagellar transport proteins in the skeleton Polycystin-1 mediates mechanical strain-induced osteoblastic mechanoresponses via potentiation of intracellular calcium and Akt/β-catenin pathway Insulin, fat, and bone: multiple interactions lead to complex biology.Conditional deletion of Pkd1 in osteocytes disrupts skeletal mechanosensing in mice.Mechanosensation and Transduction in Osteocytes.Disruption of Kif3a in osteoblasts results in defective bone formation and osteopenia.Gap junctions and hemichannels in signal transmission, function and development of bone Polycystin-1 regulates skeletogenesis through stimulation of the osteoblast-specific transcription factor RUNX2-II.Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation Isolation and culture of primary osteocytes from the long bones of skeletally mature and aged mice Primary cilia are not calcium-responsive mechanosensors The polycystic kidney disease 1 (Pkd1) gene is required for the responses of osteochondroprogenitor cells to midpalatal suture expansion in mice.The osteocyte: an endocrine cell ... and more.Mechanical stimulation of polycystin-1 induces human osteoblastic gene expression via potentiation of the calcineurin/NFAT signaling axis.Primary cilia: cellular sensors for the skeleton.Characterization of primary cilia in human airway smooth muscle cells.

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P2860

Cilia-like structures and polycystin-1 in osteoblasts/osteocytes and associated abnormalities in skeletogenesis and Runx2 expression.

http://www.wikidata.org/entity/Q35634081

description

2006 nî lūn-bûn

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2006年論文

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2006年論文

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2006年论文

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2006年论文

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2006年论文

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name

Cilia-like structures and poly ...... ogenesis and Runx2 expression.

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Cilia-like structures and poly ...... ogenesis and Runx2 expression.

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Cilia-like structures and poly ...... ogenesis and Runx2 expression.

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Cilia-like structures and poly ...... ogenesis and Runx2 expression.

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Cilia-like structures and poly ...... ogenesis and Runx2 expression.

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Cilia-like structures and poly ...... ogenesis and Runx2 expression.

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Journal of Biological Chemistry

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Cilia-like structures and poly ...... togenesis and Runx2 expression

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Brenda S Magenheimer

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Dayong Guo

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Gan Zhou

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James P Calvet

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Josh Mahlios

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Lynda Bonewald

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Robin Maser

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Sarah L Dallas

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Shiqin Zhang

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Zhousheng Xiao

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P2860

Modification of the composition of polycystin-1 multiprotein complexes by calcium and tyrosine phosphorylation

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene

Superoxide mediates shock wave induction of ERK-dependent osteogenic transcription factor (CBFA1) and mesenchymal cell differentiation toward osteoprogenitors

JNK/ERK-AP-1/Runx2 induction "paves the way" to cartilage load-ignited chondroblastic differentiation

The P2X7 nucleotide receptor mediates skeletal mechanotransduction

Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease

The loss of Smad3 results in a lower rate of bone formation and osteopenia through dysregulation of osteoblast differentiation and apoptosis

PDGFRalphaalpha signaling is regulated through the primary cilium in fibroblasts

The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia

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30884-30895

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10.1074/JBC.M604772200

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41

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281

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L. Darryl Quarles

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6881015

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