Recruitment of OCRL and Inpp5B to phagosomes by Rab5 and APPL1 depletes phosphoinositides and attenuates Akt signaling.
about
OCRL localizes to the primary cilium: a new role for cilia in Lowe syndromeDeciphering the roles of phosphoinositide lipids in phagolysosome biogenesisComparative Anatomy of Phagocytic and Immunological SynapsesThe cellular and physiological functions of the Lowe syndrome protein OCRL1Phosphoinositides: tiny lipids with giant impact on cell regulationPhosphoinositides: Key modulators of energy metabolismOCRL1 engages with the F-BAR protein pacsin 2 to promote biogenesis of membrane-trafficking intermediates.PtdIns(4,5)P₂ and PtdIns3P coordinate to regulate phagosomal sealing for apoptotic cell clearance.Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins.Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway.The CD20 homologue MS4A4 directs trafficking of KIT toward clathrin-independent endocytosis pathways and thus regulates receptor signaling and recyclingMultiphasic dynamics of phosphatidylinositol 4-phosphate during phagocytosis.Identification of inhibitors of inositol 5-phosphatases through multiple screening strategies.The combined therapy myo-inositol plus D-chiro-inositol, rather than D-chiro-inositol, is able to improve IVF outcomes: results from a randomized controlled trial.Charcot-Marie-Tooth type 2B disease-causing RAB7A mutant proteins show altered interaction with the neuronal intermediate filament peripherin.Rab31 and APPL2 enhance FcγR-mediated phagocytosis through PI3K/Akt signaling in macrophagesA role of OCRL in clathrin-coated pit dynamics and uncoating revealed by studies of Lowe syndrome cells.Rab proteins and the compartmentalization of the endosomal systemThe Lowe syndrome protein OCRL1 is required for endocytosis in the zebrafish pronephric tubule.Inositol Polyphosphate-4-Phosphatase Type I Negatively Regulates Phagocytosis via Dephosphorylation of Phagosomal PtdIns(3,4)P2.The endosomal adaptor protein APPL1 impairs the turnover of leading edge adhesions to regulate cell migration.Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer's disease.Inositol 5-phosphatases: insights from the Lowe syndrome protein OCRL.Inositol lipid phosphatases in membrane trafficking and human disease.Phosphoinositides and engulfmentOverexpression of the Endosomal Anion/Proton Exchanger ClC-5 Increases Cell Susceptibility toward Clostridium difficile Toxins TcdA and TcdB.The life cycle of phagosomes: formation, maturation, and resolution.Phagocytosis: Hungry, Hungry Cells.Rab GTPases and their interacting protein partners: Structural insights into Rab functional diversity.Amyloid precursor protein and endosomal-lysosomal dysfunction in Alzheimer's disease: inseparable partners in a multifactorial disease.The 5-phosphatase OCRL in Lowe syndrome and Dent disease 2.Mono-ubiquitination of syntaxin 3 leads to retrieval from the basolateral plasma membrane and facilitates cargo recruitment to exosomes.Distinct Roles for APPL1 and APPL2 in Regulating Toll-like Receptor 4 Signaling in Macrophages.DEEPN as an Approach for Batch Processing of Yeast 2-Hybrid Interactions.Vacuolin-1 potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A.Programmed Cell Death During Caenorhabditis elegans DevelopmentDown-regulation of Rac GTPase-activating protein OCRL1 causes aberrant activation of Rac1 in osteoarthritis development.Vangl2 regulates E-cadherin in epithelial cells.Inhibitory receptor FcγRIIb mediates the effects of IgG on a phagosome acidification and a sequential dephosphorylation system comprising SHIPs and Inpp4a.Disruption of amyloid precursor protein ubiquitination selectively increases amyloid β (Aβ) 40 levels via presenilin 2-mediated cleavage.
P2860
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P2860
Recruitment of OCRL and Inpp5B to phagosomes by Rab5 and APPL1 depletes phosphoinositides and attenuates Akt signaling.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Recruitment of OCRL and Inpp5B ...... and attenuates Akt signaling.
@ast
Recruitment of OCRL and Inpp5B ...... and attenuates Akt signaling.
@en
type
label
Recruitment of OCRL and Inpp5B ...... and attenuates Akt signaling.
@ast
Recruitment of OCRL and Inpp5B ...... and attenuates Akt signaling.
@en
prefLabel
Recruitment of OCRL and Inpp5B ...... and attenuates Akt signaling.
@ast
Recruitment of OCRL and Inpp5B ...... and attenuates Akt signaling.
@en
P2860
P356
P1476
Recruitment of OCRL and Inpp5B ...... and attenuates Akt signaling.
@en
P2093
Daniel M Balkin
Michal Bohdanowicz
P2860
P304
P356
10.1091/MBC.E11-06-0489
P577
2011-11-09T00:00:00Z