A Cdk5-dependent switch regulates Lis1/Ndel1/dynein-driven organelle transport in adult axons.
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Axonal transport: cargo-specific mechanisms of motility and regulationLoad-induced enhancement of Dynein force production by LIS1-NudE in vivo and in vitroUNC-16 (JIP3) Acts Through Synapse-Assembly Proteins to Inhibit the Active Transport of Cell Soma Organelles to Caenorhabditis elegans Motor Neuron Axons.Lis1 acts as a "clutch" between the ATPase and microtubule-binding domains of the dynein motor.A Tale of the Good and Bad: Remodeling of the Microtubule Network in the Brain by Cdk5Establishing a novel knock-in mouse line for studying neuronal cytoplasmic dynein under normal and pathologic conditionsLis1 is an initiation factor for dynein-driven organelle transport.Lissencephaly-1 promotes the recruitment of dynein and dynactin to transported mRNAsMechanism and regulation of cytoplasmic dyneinLocal synthesis of dynein cofactors matches retrograde transport to acutely changing demandsOrdered recruitment of dynactin to the microtubule plus-end is required for efficient initiation of retrograde axonal transport.At the Fulcrum in Health and Disease: Cdk5 and the Balancing Acts of Neuronal Structure and Physiology.Dendrite arborization requires the dynein cofactor NudECytoplasmic dynein and early endosome transportCyclin-dependent kinase 5 regulates the polarized trafficking of neuropeptide-containing dense-core vesicles in Caenorhabditis elegans motor neurons.Reducing Lissencephaly-1 levels augments mitochondrial transport and has a protective effect in adult Drosophila neurons.Cyclin dependent kinase 5 is required for the normal development of oligodendrocytes and myelin formation.LIS1 deficiency promotes dysfunctional synaptic integration of granule cells generated in the developing and adult dentate gyrus.NDE1 and NDEL1: twin neurodevelopmental proteins with similar 'nature' but different 'nurture'.Nudel/NudE and Lis1 promote dynein and dynactin interaction in the context of spindle morphogenesis.PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis.LIS1 and DCX: Implications for Brain Development and Human Disease in Relation to Microtubules.Lissencephaly-1 dependent axonal retrograde transport of L1-type CAM Neuroglian in the adult drosophila central nervous system.Intracellular Protein Shuttling: A Mechanism Relevant for Myelin Repair in Multiple Sclerosis?Cytoplasmic dynein and its regulatory proteins in Golgi pathology in nervous system disorders.A STRIPAK complex mediates axonal transport of autophagosomes and dense core vesicles through PP2A regulation.GSK-3β Phosphorylation of Cytoplasmic Dynein Reduces Ndel1 Binding to Intermediate Chains and Alters Dynein MotilityNDE1 and NDEL1 from genes to (mal)functions: parallel but distinct roles impacting on neurodevelopmental disorders and psychiatric illness.Differential effects of the dynein-regulatory factor Lissencephaly-1 on processive dynein-dynactin motility.Stress-Induced CDK5 Activation Disrupts Axonal Transport via Lis1/Ndel1/Dynein.Lissencephaly-1 is a context-dependent regulator of the human dynein complex.The tumor suppressor FBW7 controls ciliary length.Combinatorial regulation of the balance between dynein microtubule end accumulation and initiation of directed motility.Lis1 Has Two Opposing Modes of Regulating Cytoplasmic Dynein.NudE regulates dynein at kinetochores but is dispensable for other dynein functions in the C. elegans early embryo.Distinct functions of nuclear distribution proteins LIS1, Ndel1 and NudCL in regulating axonal mitochondrial transport.An Essential Postdevelopmental Role for Lis1 in Mice.Dynein binds and stimulates axonal motility of the endosome adaptor and NEEP21 family member, calcyon.CDK5-dependent activation of dynein in the axon initial segment regulates polarized cargo transport in neurons.Rotation of endosomes demonstrates coordination of molecular motors during axonal transport.
P2860
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P2860
A Cdk5-dependent switch regulates Lis1/Ndel1/dynein-driven organelle transport in adult axons.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
A Cdk5-dependent switch regula ...... elle transport in adult axons.
@ast
A Cdk5-dependent switch regula ...... elle transport in adult axons.
@en
type
label
A Cdk5-dependent switch regula ...... elle transport in adult axons.
@ast
A Cdk5-dependent switch regula ...... elle transport in adult axons.
@en
prefLabel
A Cdk5-dependent switch regula ...... elle transport in adult axons.
@ast
A Cdk5-dependent switch regula ...... elle transport in adult axons.
@en
P2860
P1476
A Cdk5-dependent switch regula ...... elle transport in adult axons.
@en
P2093
Deanna S Smith
Jai P Pandey
P2860
P304
17207-17219
P356
10.1523/JNEUROSCI.4108-11.2011
P407
P577
2011-11-01T00:00:00Z